Cerezyme Side Effects

Generic Name: imiglucerase

Note: This page contains information about the side effects of imiglucerase. Some of the dosage forms included on this document may not apply to the brand name Cerezyme.

Not all side effects for Cerezyme may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to imiglucerase: intravenous powder for solution

Along with its needed effects, imiglucerase (the active ingredient contained in Cerezyme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of imiglucerase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abdominal discomfort
  • decrease in blood pressure, decrease in frequency of urination
  • dizziness
  • headache
  • itching
  • nausea
  • rash

For Healthcare Professionals

Applies to imiglucerase: intravenous powder for injection


Hypersensitivity side effects including symptoms suggestive of hypersensitivity have been noted in approximately 6.6% of patients. Anaphylactoid reaction has also been reported.

Onset of hypersensitivity symptoms has occurred during or shortly after infusions. These symptoms include pruritus, flushing, urticaria, angioedema, chest discomfort, dyspnea, coughing, cyanosis, and hypotension. Each of these events was found to occur in less than 1.5% of the total patient population. Pretreatment with antihistamines and/or corticosteroids and reduced rate of infusion have allowed continued use of imiglucerase in most patients.


Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported have been reported in less than 1.5% of the total patient population.


General side effects including fatigue, headache, abdominal pain, fever, dizziness, chills, and backache have been reported in less than 1.5% of the total patient population.


Local side effects including discomfort, pruritus, burning, swelling or sterile abscess at the site of venipuncture. Each of these events was found to occur in less than 1% of the total patient population.


Cardiovascular side effects including tachycardia (less than 1.5%) have been reported. In addition to the adverse reactions that have been reported in patients treated with imiglucerase (the active ingredient contained in Cerezyme) transient peripheral edema has been reported for this therapeutic class of drug.


Dermatologic side effects including rash (less than 1.5%) have been reported.

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