Brimonidine topical Side Effects

Not all side effects for brimonidine topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to brimonidine topical: topical application gel/jelly

Along with its needed effects, brimonidine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine topical:

More common
  • Flushing or redness of the skin
  • unusually warm skin
Less common
  • Blemishes on the skin
  • blistering, burning, crusting, dryness, or flaking of the skin
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • pimples

Some side effects of brimonidine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to brimonidine topical: topical gel


The most commonly reported adverse reactions are erythema, pruritus, flushing and skin burning sensation.


Common (1% to 10%): Erythema, pruritus, skin burning sensation, rosacea, allergic contact dermatitis
Uncommon (0.1% to 1%): Dermatitis, skin irritation, warm skin, contact dermatitis, dry skin, pain of skin, skin discomfort, papular rash, acne


Common (1% to 10%): Allergic contact dermatitis


Common (1% to 10%): Flushing

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Paresthesia


Common (1% to 10%): Blurred vision, increased intraocular pressure
Uncommon (0.1% to 1%): Eyelid edema


Common (1% to 10%): Nasopharyngitis
Uncommon (0.1% to 1%): Nasal congestion


Uncommon (0.1% to 1%): Dry mouth


Uncommon (0.1% to 1%): Feeling hot, peripheral coldness

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