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Avonex Pen Side Effects

Generic name: interferon beta-1a

Medically reviewed by Drugs.com. Last updated on Jul 13, 2024.

Note: This document provides detailed information about Avonex Pen Side Effects associated with interferon beta-1a. Some dosage forms listed on this page may not apply specifically to the brand name Avonex Pen.

Applies to interferon beta-1a: kit, solution.

Serious side effects of Avonex Pen

Along with its needed effects, interferon beta-1a (the active ingredient contained in Avonex Pen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking interferon beta-1a:

More common

  • black, tarry stools
  • chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • flu-like symptoms
  • headache
  • joint pain
  • muscle aches
  • nausea
  • pain
  • painful or difficult urination
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • clumsiness or unsteadiness
  • decreased hearing
  • difficulty with swallowing
  • dizziness
  • fainting
  • feeling of warmth
  • hives or itching
  • mood changes, especially with thoughts of suicide
  • muscle spasms
  • pain or discharge from the vagina
  • pelvic discomfort, aching, or heaviness
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness, swelling, or tenderness at the injection site
  • runny or stuffy nose
  • seizures
  • skin lesions
  • sneezing
  • sore throat
  • speech problems
  • stomach pain
  • swelling of the face, lips, or eyelids

Rare

  • earache
  • general feeling of discomfort or illness
  • loss of appetite
  • painful blisters on trunk of the body
  • painful cold sores or blisters on the lips, nose, eyes, or genitals

Incidence not known

  • bleeding gums
  • blue-green to black skin discoloration
  • blood in the urine or stools
  • bloody nose
  • chest discomfort or tightness
  • confusion
  • constipation
  • dark urine
  • decreased urine output
  • depressed mood
  • dilated neck veins
  • dry skin and hair
  • fast, irregular, or pounding heartbeat
  • feeling cold
  • general tiredness and weakness
  • hair loss
  • heavier menstrual periods
  • high fever
  • irregular breathing
  • light-colored stools
  • loss of bladder control
  • mental depression
  • mood or other mental changes
  • muscle cramps and stiffness
  • nausea or vomiting
  • nervousness
  • pain, redness, or sloughing of skin at the place of injection
  • pale skin
  • persistent loss of appetite
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids, or around the eyes, face, lips, or tongue
  • redness, blistering, peeling, or loosening of the skin
  • sensitivity to heat
  • skin rash
  • slowed heartbeat
  • sudden loss of consciousness
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swelling of the mouth or throat
  • throat tightness
  • upper right stomach pain or tenderness
  • weight gain or loss
  • yellow eyes and skin

Other side effects of Avonex Pen

Some side effects of interferon beta-1a may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • heartburn
  • indigestion
  • sour stomach

Less common

  • hair loss
  • trouble sleeping

For healthcare professionals

Applies to interferon beta-1a: intramuscular kit, intramuscular powder for injection, subcutaneous kit, subcutaneous solution.

General

Influenza-like symptoms (e.g., myalgia, fever, chills, sweating, asthenia, headache, nausea) are the most common adverse reactions.[Ref]

Hematologic

Gastrointestinal

Dermatologic

Endocrine

Cardiovascular

Genitourinary

Hepatic

Hypersensitivity

Immunologic

Local

Musculoskeletal

Nervous system

Metabolic

Ocular

Other

Psychiatric

Respiratory

Renal

References

1. (2001) "Product Information. Avonex (interferon beta-1a)." Biogen

2. (2002) "Product Information. Rebif (interferon beta-1a)." Serono Laboratories Inc

3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

4. Cerner Multum, Inc. "Australian Product Information."

More about Avonex Pen (interferon beta-1a)

Patient resources

Other brands

Rebif, Rebif Rebidose

Professional resources

Other brands

Rebif

Other formulations

Related treatment guides

Further information

Avonex Pen side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.