Selzentry

Generic Name: maraviroc (ma RAV i rok)
Brand Names: Selzentry

What is Selzentry?

Selzentry (maraviroc) is an antiviral medication that prevents certain viral cells from multiplying in your body.

Selzentry is used together with other medications. to treat CCR5-tropic human immunodeficiency virus (HIV) type 1. Maraviroc is not a cure for HIV or AIDS.

Selzentry may also be used for purposes not listed in this medication guide.

Important information about Selzentry

You should not take Selzentry if you have severe kidney disease and you are also using certain drugs. Tell your doctor about all other medications you use.

Before taking Selzentry, tell your doctor if you have kidney disease, liver disease (especially hepatitis B or C), heart disease, low blood pressure, any type of allergy, circulation problems, or if you have ever had a stroke.

Call your doctor at once if you have signs of liver damage: low fever, itching, nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

There are many other drugs that can interact with Selzentry. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Keep a list of all your medicines and show it to any healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of different drugs. Selzentry must be given in combination with other antiviral medications. Use all medications as directed by your doctor.

Taking Selzentry will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Before taking Selzentry

You should not use Selzentry if you are allergic to maraviroc.

To make sure you can safely take Selzentry, tell your doctor if you have any of these other conditions:

• kidney disease;

• liver disease, especially hepatitis B or C;

• heart disease;

• low blood pressure;

• any type of allergy;

• circulation problems; or

• if you have ever had a stroke.

FDA pregnancy category B. Selzentry is not expected to be harmful to an unborn baby, but HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection.

See also: Selzentry pregnancy and breastfeeding warnings (in more detail)

If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Selzentry on the baby.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take Selzentry?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may take Selzentry with or without food. Selzentry is usually taken twice per day. Follow your doctor's instructions.

Do not crush, chew, or break the Selzentry tablet. Swallow the pill whole.

Use Selzentry regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of different drugs. Selzentry must be given in combination with other antiviral medications and it should not be used alone. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store Selzentry at room temperature away from moisture and heat.

See also: Selzentry dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 6 hours late in taking your Selzentry, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling like you might pass out.

What should I avoid while taking Selzentry?

Selzentry may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Taking Selzentry will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Selzentry side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Selzentry: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Selzentry may also cause severe liver symptoms. Stop taking Selzentry and call your doctor at once if you have any of these liver symptoms:

• low fever, itching;

• nausea, upper stomach pain, loss of appetite;

• dark urine, clay-colored stools; or

• jaundice (yellowing of the skin or eyes).

Call your doctor at once if you have any other serious side effect, such as:

• skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

• sudden numbness, tingling, or weakness anywhere in your body;

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

• cold sores, sores on your genital or anal area;

• white patches or sores inside your mouth or on your lips; or

• signs of a new infection, such as fever or chills, cough, or flu symptoms.

Less serious Selzentry side effects may include:

• cold symptoms such as stuffy nose, sneezing, cough, sore throat;

• diarrhea, constipation;

• sleep problems (insomnia);

• swelling;

• problems with urination;

• muscle or joint pain;

• dizziness; or

• mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Selzentry side effects (in more detail)

What other drugs will affect Selzentry?

You should not take Selzentry if you have severe kidney disease and you are also using certain drugs. Tell your doctor about all other medications you use.

Many drugs can interact with Selzentry. Below is just a partial list. Tell your doctor if you are using:

• bosentan (Tracleer);

• conivaptan (Vaprisol);

• dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

• imatinib (Gleevec);

• isoniazid (for treating tuberculosis);

• nefazodone;

• St. John's wort;

• an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);

• antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

• a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);

• heart or blood pressure medication such as nicardipine (Cardene) or quinidine (Quin-G);

• HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), didanosine (Videx), efavirenz (Atripla, Sustiva), emtricitabine (Emtriva), enfuvirtide (Fuzeon), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lamivudine (Epivir, Combivir, Trizivir), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), saquinavir (Invirase), stavudine (Zerit), tipranavir (Aptivus), zalcitabine (Hivid), zidovudine (Retrovir);

• medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); or

• seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

This list is not complete and there are many other drugs that can interact with Selzentry. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

• Your pharmacist can provide more information about Selzentry.