 |
Selzentry Dosage
Generic name: maraviroc
Dosage form: tablet, film coated
This dosage information does not include all the information needed to use Selzentry safely and effectively. See full prescribing information for Selzentry.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Dose Recommendations for Patients With Normal Renal Function
The recommended dose of SELZENTRY differs based on concomitant medications due to drug interactions (see Table 1). SELZENTRY can be taken with or without food. SELZENTRY must be given in combination with other antiretroviral medications.
Table 1 gives the recommended dose adjustments [see Drug Interactions (7.1)].
| Concomitant Medications | Dose of SELZENTRY |
| Potent CYP3A inhibitors (with or without a potent CYP3A inducer) including:
| 150 mg twice daily |
| Other concomitant medications, including tipranavir/ritonavir, nevirapine, raltegravir, all NRTIs, and enfuvirtide | 300 mg twice daily |
| Potent CYP3A inducers (without a potent CYP3A inhibitor) including:
| 600 mg twice daily |
Dose Recommendations for Patients With Renal Impairment
Table 2 provides dosing recommendations for patients based on renal function and concomitant medications.
| Concomitant Medicationsa | Dose of SELZENTRY Based on Renal Function | ||||
| Normal (CrCl>80 mL/min) | Mild (CrCl >50 and ≤80 mL/min) | Moderate (CrCl ≥30 and ≤50 mL/min) | Severe (CrCl <30 mL/min) | End-Stage Renal Disease On Regular Hemodialysis | |
| Potent CYP3A inhibitors (with or without a CYP3A inducer)a | 150 mg twice daily | 150 mg twice daily | 150 mg twice daily | NR | NR |
| Other concomitant medicationsa | 300 mg twice daily | 300 mg twice daily | 300 mg twice daily | 300 mg twice dailyb | 300 mg twice dailyb |
| Potent CYP3A Inducers (without a potent CYP3A inhibitor)a | 600 mg twice daily | 600 mg twice daily | 600 mg twice daily | NR | NR |
NR = Not recommended.
aSee Table 1 for the list of concomitant medications.
bThe dose of SELZENTRY should be reduced to 150 mg twice daily if there are any symptoms of postural hypotension [see Warnings and Precautions (5.3)].
