- Tablets, chewable 100 mg
Kills parasitic worms by blocking glucose uptake, thus depleting stored glycogen. Without glycogen, parasite cannot reproduce or survive.
Mebendazole is poorly absorbed (approximately 5% to 10%). T max is 0.5 to 7 h and C max is 0.03 mcg/mL. Food increases the absorption of mebendazole.
Mebendazole is distributed to serum, cyst fluids, liver, omental fat, pelvic cysts, pulmonary cysts, hepatic cysts, and muscles. Mebendazole also crosses the placenta. Protein binding is 90% to 95%.
All metabolites are inactive. The major metabolite is 2-amino-5-benzoylbenzimidazole. Mebendazole is primarily metabolized hepatically.
Mebandazole is excreted in the feces and a small amount in urine. The t ½ is 2.5 to 9 h.
Special PopulationsHepatic Function Impairment
The t ½ is prolonged to approximately 30 h.
Indications and Usage
Treatment of pinworm ( Enterobius vermicularis ), round worm ( Ascaris lumbricoides ), common hookworm ( Ancylostoma duodenale ), American hookworm ( Necator americanus ), and whipworm ( Trichuris trichiura ) in single or mixed parasitic infections.
Dosage and AdministrationTrichuriasis, Ascariasis, and Hookworm Infection
Adults and Children
PO 100 mg tablet AM and PM on 3 consecutive days.Ascaris Infection
Adults and Children Alternative dose
PO 500 mg as single dose.Enterobiasis
Adults and Children
PO 100 mg as single dose.
Store in tightly closed container at room temperature.
Drug InteractionsCarbamazepine; hydantoins (eg, phenytoin)
Pharmacological effects of mebendazole may be decreased.
Laboratory Test Interactions
None well documented.
Transient abdominal pain and diarrhea.
Category C .
Safety and efficacy in children younger than 2 yr of age not established.
- Advise patient to chew tablet or to crush tablet and mix with food.
- Instruct patient to wash clothing, bed linens, and towels daily and to disinfect bathroom facilities daily.
- Advise that infected person sleep alone.
- Caution patient not to put fingers in mouth.
- Emphasize importance of thorough hand washing, especially after toileting, to avoid reinfecting self.
- Explain that all family members should be treated to eradicate infestation.
- Tell patient that second treatment is sometimes necessary.
- Instruct family/patient to call health care provider if fever, abdominal pain, or diarrhea develops.
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