| The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before taking this drug. |
Trade Names:
Endrate
- Injection 150 mg/mL
Forms chelates with polyvalent metals, especially calcium, thus increasing their urinary excretion.
The chelate formed is excreted in the urine.
Emergency treatment of hypercalcemia; control of ventricular arrhythmias associated with digitalis toxicity.
Anuria.
IV 50 mg/kg/day (max 3 g/day). Usually administered in 5 consecutive daily doses followed by 2 days without medication, with repeated courses as needed, for total of 15 doses.
Dissolve 50 mg/kg dose in 500 mL of D5W or sodium chloride 0.9% for injection. Infuse over 3 h or more.
ChildrenIV 40 mg/kg/day (max 70 mg/kg/day) or 15 to 50 mg/kg/day (max 3 g/day) with 5 days between courses.
Dissolve drug in sufficient volume of D5W or sodium chloride 0.9% for injection to bring final concentration to 3% or less. Infuse over 3 h or more.
Do not confuse edetate disodium with edetate calcium disodium.
Store at room temperature.
None well documented.
None well documented.
Transient drop in BP; adverse reactions on myocardial contractility; thrombophlebitis.
Transient circumoral paresthesia; numbness; headache.
Exfoliative dermatitis; toxic skin and mucous membrane reactions.
Nausea; vomiting; diarrhea.
Nephrotoxicity; damage to reticuloendothelial system.
Thrombophlebitis; anemia.
Electrolyte imbalances including hypocalcemia, hypokalemia, and hypomagnesemia; hyperuricemia.
Febrile reactions.
MonitorHypocalcemiaIf signs or symptoms of hypocalcemia occur (eg, circumoral numbness/tingling, positive Chvostek's or Trousseau's signs, tetany), notify health care provider. |
Category C .
Undetermined.
Use drug cautiously in patients with limited cardiac reserve or incipient congestive failure.
Blood sugar and insulin requirements may be lower in insulin-dependent diabetic patients.
Adequately hydrate patient before administration.
Rapid IV infusion or high serum concentrations can cause a precipitous and potentially fatal drop in serum calcium. Do not exceed maximum dose or rate.
Drop in serum calcium.