Carisoprodol
Pronouncation: (car-eye-so-PRO-dole)Class: Skeletal muscle relaxant, centrally acting
Trade Names:
Soma
- Tablets 350 mg
Pharmacology
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Produces skeletal muscle relaxation, probably as result of its sedative properties.
Pharmacokinetics
Metabolism
Metabolized in the liver.
Elimination
Eliminated via the urine.
Onset
30 min.
Duration
4 to 6 h.
Indications and Usage
Adjunctive treatment of acute, painful musculoskeletal conditions (eg, muscle strain).
Contraindications
Acute intermittent porphyria; hypersensitivity to related compounds such as meprobamate; suspected porphyria.
Dosage and Administration
AdultPO 350 mg 3 or 4 times daily.
General Advice
Give with food or milk if GI upset occurs.
Storage/Stability
Store in tightly closed container in cool, dry place.
Drug Interactions
Alcohol and other CNS depressantsMay cause additive CNS depression.
Laboratory Test Interactions
None well documented.
Adverse Reactions
Cardiovascular
Tachycardia; orthostatic hypotension; facial flushing.
CNS
Dizziness; drowsiness; vertigo; ataxia; tremor; agitation; irritability; headache; depressive reactions; syncope; insomnia.
GI
Nausea; vomiting; hiccoughs; epigastric distress.
Miscellaneous
Allergic or idiosyncratic reactions within first to fourth doses, including skin rash, erythema multiforme, pruritus, eosinophilia, and fixed drug eruption; severe reactions include asthma, fever, weakness, dizziness, angioneurotic edema, hypotension, and anaphylactoid shock.
Precautions
MonitorIdiosyncratic responseMonitor for signs of idiosyncratic response: disorientation, agitation, vision disturbances, impaired verbal communication, extreme weakness, transient quadriplegia, dizziness, ataxia, euphoria. These reactions may appear within minutes or hours of first dose. Symptoms usually subside over several hours. If such reactions occur, withhold drug and notify health care provider. |
Pregnancy
Undetermined.
Lactation
Excreted in breast milk.
Children
Not recommended in children younger than 12 yr of age.
Renal Function
Use with extreme caution.
Hepatic Function
Use with extreme caution.
Tartrazine Sensitivity
Some products contain tartrazine, which may cause allergic reactions (including bronchial asthma) in susceptible individuals. Such patients often also have aspirin hypersensitivity.
Drug dependency
Use with caution in addiction-prone patients.
Overdosage
Symptoms
Stupor, coma, shock, respiratory depression.
Patient Information
- Instruct patient to take last daily dose at bedtime.
- Tell patient to take medication with meals if GI upset occurs.
- Instruct patient to report these symptoms to health care provider: palpitations, tremors, hiccough, ataxia.
- Advise patient to avoid intake of alcoholic beverages or other CNS depressants.
- Caution patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
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More Carisoprodol resources:
Carisoprodol - Includes detailed dosage instructions.
Carisoprodol Drug Interactions
