doxycycline

Generic Name: doxycycline (DOX i SYE kleen)
Brand names: Adoxa, Alodox, Avidoxy, Doryx, Monodox, Oracea, Oraxyl, Periostat, Vibra-Tabs, Vibramycin, Vibramycin Calcium, Vibramycin Monohydrate, ...show all 18 brand names.Doxy-D, Vibramycin Hyclate, Doxy Lemmon, Doxy-Caps, Adoxa TT, Adoxa CK

What is doxycycline?

Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.

Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others.

Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxycycline will not treat facial redness caused by rosacea.

Doxycycline may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about doxycycline?

Do not use this medication if you are pregnant. It could cause harm to the unborn baby, including permanent discoloration of the teeth later in life. Doxycycline can make birth control pills less effective. Use a second method of birth control while you are taking doxycycline to keep from getting pregnant. Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). Before taking doxycycline, tell your doctor if you have liver or kidney disease. You may not be able to take doxycycline, or you may need a dose adjustment or special tests during treatment. Do not give doxycycline to a child younger than 8 years old. Doxycycline can cause permanent yellowing or graying of the teeth, and it can affect a child's growth. Throw away any unused doxycycline when it expires or when it is no longer needed. Do not take any doxycycline after the expiration date printed on the bottle. Expired doxycycline can cause a dangerous syndrome resulting in damage to the kidneys.

What should I discuss with my healthcare provider before taking doxycycline?

Do not use this medication if you are allergic to doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap). If you have liver or kidney disease, you may need a dose adjustment or special tests to safely take doxycycline.

If you are using doxycycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.

Do not use doxycycline syrup (Vibramycin) without first talking to your doctor if you have asthma or are allergic to sulfites.

FDA pregnancy category D. This medication can cause harm to an unborn baby, including permanent discoloration of the teeth later in life. Do not use doxycycline without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Doxycycline can make birth control pills less effective. Use a non-hormonal method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while you are taking doxycycline. Doxycycline passes into breast milk and may affect bone and tooth development in a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. Children younger than 8 years old should not take doxycycline. Doxycycline can cause permanent tooth discoloration and can also affect a child's growth.

How should I take doxycycline?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take doxycycline with a full glass of water (8 ounces).

You may take this medication with or without food. Do not take the medication with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine. Certain brands of doxycycline may not have restrictions about taking them with dairy products. If your doctor has instructed you to take doxycycline with milk, tell your pharmacist that you need a brand of doxycycline that can be taken with milk.

Do not crush, break, or open a delayed-release capsule (Orecea). Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Doxycycline will not treat a viral infection such as the common cold or flu. Do not give this medicine to another person, even if they have the same condition you have.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking doxycycline. You may need to stop using the medicine for a short time.

Throw away any unused doxycycline when it expires or when it is no longer needed. Do not take any doxycycline after the expiration date printed on the label. Using expired doxycycline can cause damage to your kidneys. Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, and diarrhea.

What should I avoid while taking doxycycline?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Doxycycline can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline.

Doxycycline side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using doxycycline and call your doctor at once if you have any of these serious side effects:

• severe headache, dizziness, blurred vision;

• fever, chills, body aches, flu symptoms;

• severe blistering, peeling, and red skin rash;

• urinating less than usual or not at all;

• pale or yellowed skin, dark colored urine, fever, confusion or weakness;

• severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

• loss of appetite, jaundice (yellowing of the skin or eyes); or

• easy bruising or bleeding, unusual weakness.

Less serious side effects may include:

• swollen tongue, trouble swallowing;

• mild nausea, vomiting, diarrhea, or stomach upset;

• white patches or sores inside your mouth or on your lips;

• sores or swelling in your rectal or genital area; or

• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Doxycycline Dosing Information

Usual Adult Dose for Acne:

Initial dose: 100 mg orally twice a day for 3 to 6 weeks, or until improvement occurs
Maintenance dose: 50 to 150 mg orally once a day

Usual Adult Dose for Acne Rosacea:

100 mg orally twice daily

Oracea delayed-release capsule: 1 capsule (40 mg) orally once daily in the morning on an empty stomach, preferably at least one hour prior to or two hours after meals

Usual Adult Dose for Actinomycosis:

Penicillin-allergic patients: 100 mg orally or IV every 12 hours for as long as 6 to 12 months

Usual Adult Dose for Amebiasis:

100 mg orally twice daily as an adjunct to amebicides

Usual Adult Dose for Anthrax Prophylaxis:

Postexposure prophylaxis: 100 mg orally every 12 hours for 60 days following initial exposure
The Working Group on Civilian Biodefense has recommended doxycycline as an alternative agent to ciprofloxacin for postexposure anthrax prophylaxis after an intentional Bacillus anthracis release.

Usual Adult Dose for Cutaneous Bacillus anthracis:

100 mg orally every 12 hours for 60 days following initial exposure
Intravenous therapy with multiple drugs is recommended if there is evidence of systemic involvement or if head or neck lesions are present.

The Working Group on Civilian Biodefense has recommended ciprofloxacin or doxycycline for the treatment of cutaneous anthrax after an intentional Bacillus anthracis release.

Usual Adult Dose for Inhalation Bacillus anthracis:

100 mg orally or IV every 12 hours for a total of 60 days
One or two additional antibiotics with activity against anthrax should also be given (i.e., rifampin, vancomycin, penicillin, ampicillin, chloramphenicol, ciprofloxacin, imipenem, clindamycin, or clarithromycin). The switch from IV to oral therapy should be made as soon as it is clinically feasible.

Treatment for anthrax used as a biological weapon:

Contained-casualty setting: 100 mg IV every 12 hours plus one or two additional antibiotics; may switch to oral therapy when clinically appropriate, for total treatment duration of 60 days
The Working Group on Civilian Biodefense has recommended ciprofloxacin or doxycycline for the treatment of pulmonary anthrax in a contained-casualty setting.

Mass-casualty setting: 100 mg orally every 12 hours for 60 days
The Working Group on Civilian Biodefense has recommended doxycycline as an alternative to ciprofloxacin for the treatment of pulmonary anthrax in a mass-casualty setting.

Usual Adult Dose for Bartonellosis:

100 mg orally or IV twice daily (in combination with rifampin 300 mg twice daily for severe disease)

Duration:
Mild to moderate disease: 10 to 14 days
Bacillary angiomatosis: 8 weeks
Neuroretinitis: 4 to 6 weeks
Osteomyelitis or peliosis hepatitis: 4 months

Usual Adult Dose for Upper Respiratory Tract Infection:

100 mg orally every 12 hours for 7 to 10 days

Usual Adult Dose for Bronchitis:

100 mg orally every 12 hours for 7 to 10 days

Usual Adult Dose for Brucellosis:

100 mg orally twice daily for 6 weeks, in combination with gentamicin, streptomycin, or rifampin

Usual Adult Dose for Chlamydia Infection:

Urethral, endocervical, or rectal infection: 100 mg orally twice a day for 7 days

Single-dose azithromycin is the preferred agent if patient compliance is questionable.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Cholera:

300 mg orally once, as an adjunct to fluid and electrolyte replacement

Usual Adult Dose for Epididymitis -- Sexually Transmitted:

100 mg orally twice a day for 10 days, in conjunction with ceftriaxone

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Gastroenteritis:

Due to Listeria monocytogenes or Yersinia enterocolitica: 100 mg orally twice daily

Due to Tropheryma whippelii: 100 mg orally twice daily for 1 year after initial 10- to 14-day therapy with penicillin G, streptomycin or ceftriaxone

Usual Adult Dose for Granuloma Inguinale:

100 mg orally twice daily for at least 3 weeks or until all lesions have healed
Gentamicin may be added if no improvement is observed after several days.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Inclusion Conjunctivitis:

100 mg orally twice daily for 7 to 21 days

Usual Adult Dose for Lyme Disease -- Arthritis:

100 mg orally every 12 hours for 14 to 28 days

Usual Adult Dose for Lyme Disease -- Carditis:

100 mg orally every 12 hours for 14 to 28 days

Usual Adult Dose for Lyme Disease -- Erythema Chronicum Migrans:

100 mg orally every 12 hours for 14 to 21 days

Usual Adult Dose for Lyme Disease -- Neurologic:

100 mg orally every 12 hours for 14 to 28 days

Usual Adult Dose for Lymphogranuloma Venereum:

100 mg orally twice daily for 21 days or until symptoms have resolved; patients with HIV may require longer therapy

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Malaria:

Chloroquine-resistant Plasmodium falciparum and P vivax: 100 mg orally twice daily for 7 days plus quinine sulfate 650 mg every 8 hours for 3 to 7 days

Usual Adult Dose for Malaria Prophylaxis:

Chloroquine-resistant areas: 100 mg orally once a day
Begin 1 to 2 days before travel to the malarious area. Continue daily during travel in the malarious area and for 4 weeks after leaving.

Usual Adult Dose for Melioidosis:

Doxycycline 100 mg orally twice daily plus chloramphenicol 10 mg/kg orally (not available in the United States) four times daily plus sulfamethoxazole-trimethoprim 25 mg/kg - 5 mg/kg orally twice a day
This oral regimen may be initiated after the patient has received parenteral treatment with ceftazidime, imipenem, or meropenem for at least 10 days.

Duration: Doxycycline and sulfamethoxazole-trimethoprim for 20 weeks; chloramphenicol for the first 8 weeks

Usual Adult Dose for Nongonococcal Urethritis:

100 mg orally twice daily for 7 days

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Periodontitis:

20 mg orally twice daily for up to 9 months, as an adjunct to scaling and root planing

Usual Adult Dose for Pelvic Inflammatory Disease:

100 mg orally or IV every 12 hours in combination with cefotetan, cefoxitin, or ceftriaxone, with or without metronidazole or clindamycin

Duration: 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Plague:

100 mg orally or IV twice daily for 10 days

Treatment of plague used as a biological weapon:

Contained-casualty setting: 100 mg IV twice daily or 200 mg IV once daily for 10 days; may switch to oral doxycycline when clinically indicated
The Working Group on Civilian Biodefense has recommended doxycycline as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro.

Mass-casualty setting:
Treatment: 100 mg orally twice daily for 10 days
Postexposure prophylaxis: 100 mg orally twice daily for 7 days
The Working Group on Civilian Biodefense has recommended doxycycline or ciprofloxacin for plague treatment or postexposure prophylaxis in a mass-casualty setting.

Usual Adult Dose for Pleural Effusion:

Sclerosing agent: Mix 500 mg of the powder for injection and 10 mL of lidocaine 1% in 50 mL of normal saline and inject into pleural space. Clinical trials have reported use of doses ranging from 250 mg to 1 g.

Usual Adult Dose for Mycoplasma Pneumonia:

100 mg orally or IV every 12 hours for 10 to 21 days

Usual Adult Dose for Pneumonia:

100 mg orally or IV every 12 hours for 10 to 21 days

Usual Adult Dose for Psittacosis:

100 mg orally twice daily for 7 to 10 days

Usual Adult Dose for Ornithosis:

100 mg orally twice daily for 7 to 10 days

Usual Adult Dose for Proctitis:

Sexually transmitted: 100 mg orally twice daily, in conjunction with ceftriaxone

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Enterocolitis:

Sexually transmitted: 100 mg orally twice daily, in conjunction with ceftriaxone

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Rickettsial Infection:

Rocky Mountain spotted fever, relapsing fever, or typhus: 100 mg orally or IV twice a day for 7 days

Human monocytic or granulocytic ehrlichiosis: 100 mg orally or IV twice a day for 7 to 14 days

Usual Adult Dose for Skin or Soft Tissue Infection:

Vibrio vulnificus: 100 mg IV or orally every 12 hours plus cefotaxime 2 g IV every 8 hours or ceftazidime 1 to 2 g IV every 8 hours

Usual Adult Dose for STD Prophylaxis:

Sexual assault victims: 100 mg orally twice daily for 7 days, in conjunction with metronidazole and ceftriaxone

Usual Adult Dose for Syphilis -- Early:

100 mg to 150 mg orally twice a day for 2 weeks (4 weeks if more than 1 year duration)

The patient's sexual partner(s) should also be evaluated/treated.

Penicillin is the drug of choice. Penicillin-allergic or pregnant patients should be desensitized and treated with benzathine penicillin.

Usual Adult Dose for Syphilis -- Latent:

100 mg to 150 mg orally twice a day for 28 days

The patient's sexual partner(s) should also be evaluated/treated.

Penicillin is the drug of choice. Penicillin-allergic or pregnant patients should be desensitized and treated with benzathine penicillin.

Usual Adult Dose for Tertiary Syphilis:

100 mg to 150 mg orally twice a day for 28 days

The patient's sexual partner(s) should also be evaluated/treated.

Penicillin is the drug of choice. Penicillin-allergic or pregnant patients should be desensitized and treated with benzathine penicillin.

Usual Adult Dose for Trachoma:

100 mg orally twice daily for 7 days

Usual Adult Dose for Tularemia:

100 mg orally or IV twice daily for 14 to 21 days

Treatment of tularemia used as a biological weapon:

Contained-casualty setting: 100 mg IV twice daily for 14 to 21 days; may switch to oral doxycycline when clinically indicated
The Working Group on Civilian Biodefense has recommended doxycycline or ciprofloxacin as an alternative to streptomycin and gentamicin if they are contraindicated, not available, or inactive in vitro.

Mass-casualty setting, treatment and postexposure prophylaxis: 100 mg orally twice daily for 14 days
The Working Group on Civilian Biodefense has recommended doxycycline or ciprofloxacin for tularemia treatment and prophylaxis in a mass-casualty setting.

Usual Adult Dose for Urinary Tract Infection:

Chronic: 100 mg orally every 12 hours

Usual Pediatric Dose for Bacterial Infection:

8 years or older, 45 kg or more:
Oral: 4.4 mg/kg divided into 2 doses on the first day, followed by 2.2 mg/kg once a day or in 2 divided doses; for more severe infections, 4.4 mg/kg may be used
IV: 4.4 mg/kg on the first day, given in one or two infusions, followed by 2.2 to 4.4 mg/kg, given as one or two infusions

Usual Pediatric Dose for Anthrax Prophylaxis:

Treatment of anthrax used as a biological weapon:
7 years or less: 2.2 mg/kg (maximum 100 mg) orally or IV every 12 hours for 60 days following exposure
8 years or older and 44 kg or less: 2.2 mg/kg orally or IV every 12 hours for 60 days following exposure
8 years or older and 45 kg or more: 100 mg orally or IV every 12 hours for 60 days following exposure
The switch from IV to oral therapy should be made as soon as it is clinically feasible.

The Working Group on Civilian Biodefense has suggested doxycycline as an alternative agent if ciprofloxacin is unavailable or contraindicated, for postexposure anthrax prophylaxis in a mass-casualty setting after intentional release of Bacillus anthracis.

If doxycycline oral suspension is not available, emergency doses may be prepared from tablets as follows:

1. Put a 100 mg doxycycline tablet into a small bowl and grind into a fine powder using the back of a metal teaspoon.

2. Mix the powder with 4 teaspoons of soft food or drink until the powder dissolves. Drinks work better than foods for dissolving the powder. The taste is generally acceptable when mixed in low-fat white milk, low-fat or regular chocolate milk, chocolate pudding, or apple juice mixed with sugar. Jellies, yogurt, and water do not hide the bitter taste of doxycycline. The mixture may be stored for up to 24 hours; after that, unused portions should be thrown away. Mixtures made with milk or pudding should be refrigerated.

3. Use measuring spoons, if available, to measure the correct dose of this mixture. If the child weighs:
12.5 lbs or less: Give one-half (1/2) teaspoon (12.5 mg doxycycline) twice daily
12.5 to 25 lbs: Give one (1) teaspoon (25 mg doxycycline) twice daily
25 to 37.5 lbs: Give one and one-half (1 1/2) teaspoons (37.5 mg doxycycline) twice daily
37.5 to 50 lbs: Give two (2) teaspoons (50 mg doxycycline) twice daily
50 to 62.5 lbs: Give two and one-half (2 1/2) teaspoons (62.5 mg doxycycline) twice daily
62.5 to 75 lbs: Give three (3) teaspoons (75 mg doxycycline) twice daily
75 to 87.5 lbs: Give three and one-half (3 1/2) teaspoons (87.5 mg doxycycline) twice daily
87.5 to 100 lbs: Give four (4) teaspoons (100 mg doxycycline) twice daily

Usual Pediatric Dose for Cutaneous Bacillus anthracis:

Treatment of anthrax used as a biological weapon:
7 years or less: 2.2 mg/kg (maximum 100 mg) orally every 12 hours for 60 days
8 years or older and 44 kg or less: 2.2 mg/kg orally every 12 hours for 60 days
8 years or older and 45 kg or more: 100 mg orally every 12 hours for 60 days

Intravenous therapy with multiple drugs is recommended if there is evidence of systemic involvement or if head or neck lesions are present. The switch from IV to oral therapy should be made as soon as it is clinically feasible.

The Working Group on Civilian Biodefense has recommended ciprofloxacin or doxycycline for the treatment of cutaneous anthrax after an intentional Bacillus anthracis release.

If doxycycline oral suspension is not available, emergency doses may be prepared from tablets. Refer to directions under "Anthrax Prophylaxis" for pediatric patients.

Usual Pediatric Dose for Inhalation Bacillus anthracis:

Treatment of anthrax used as a biological weapon:
7 years or less: 2.2 mg/kg (maximum 100 mg) orally or IV every 12 hours for 60 days
8 years or older and 44 kg or less: 2.2 mg/kg orally or IV every 12 hours for 60 days
8 years or older and 45 kg or more: 100 mg orally or IV every 12 hours for 60 days

One or two additional antibiotics with activity against anthrax should also be given (i.e., rifampin, vancomycin, penicillin, ampicillin, chloramphenicol, ciprofloxacin, imipenem, clindamycin, or clarithromycin). The switch from IV to oral therapy should be made as soon as it is clinically feasible.

The Working Group on Civilian Biodefense has recommended ciprofloxacin or doxycycline for the treatment of pulmonary anthrax after an intentional Bacillus anthracis release.

If doxycycline oral suspension is not available, emergency doses may be prepared from tablets. Refer to directions under "Anthrax Prophylaxis" for pediatric patients.

Usual Pediatric Dose for Chlamydia Infection:

8 years or older and 45 kg or more: 100 mg orally every 12 hours for 7 days

Single-dose azithromycin is the preferred agent.

Usual Pediatric Dose for Lyme Disease:

8 years or older: 1 to 2 mg/kg (maximum 100 mg) orally twice a day for 14 to 28 days

Usual Pediatric Dose for Malaria:

Chloroquine-resistant Plasmodium falciparum and P vivax:
8 years or older: 2 mg/kg (maximum 100 mg) orally twice daily for 7 days plus quinine sulfate 8.3 mg/kg every 8 hours for 3 to 7 days

Usual Pediatric Dose for Malaria Prophylaxis:

Chloroquine-resistant areas:
8 years or older: 2 mg/kg orally (maximum 100 mg) once a day
Begin 1 to 2 days before travel to the malarious area. Continue daily during travel in the malarious area and for 4 weeks after leaving.

Usual Pediatric Dose for Plague:

Treatment of plague used as a biological weapon:
Contained casualty setting:
44 kg or less: 2.2 mg/kg IV twice daily (maximum 200 mg/day) for 10 days; may switch to oral doxycycline when clinically indicated
45 kg or more: 100 mg IV twice daily for 10 days; may switch to oral doxycycline when clinically indicated

The Working Group on Civilian Biodefense has recommended doxycycline as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro.

Mass casualty setting:
Treatment:
44 kg or less: 2.2 mg/kg orally twice daily (maximum 200 mg/day) for 10 days
45 kg or more: 100 mg orally twice daily for 10 days

Postexposure prophylaxis:
44 kg or less: 2.2 mg/kg orally twice daily (maximum 200 mg/day) for 7 days
45 kg or more: 100 mg orally twice daily for 7 days

The Working Group on Civilian Biodefense has recommended doxycycline or ciprofloxacin for plague treatment or postexposure prophylaxis in a mass-casualty setting.

Usual Pediatric Dose for Tularemia:

Treatment of tularemia used as a biological weapon:
Contained casualty setting:
44 kg or less: 2.2 mg/kg IV twice daily (maximum 200 mg/day) for 14 to 21 days; may switch to oral doxycycline when clinically indicated
45 kg or more: 100 mg IV twice daily for 14 to 21 days; may switch to oral doxycycline when clinically indicated

The Working Group on Civilian Biodefense has recommended doxycycline as an alternative to streptomycin and gentamicin if they are contraindicated, unavailable, or inactive in vitro.

Mass casualty setting, treatment and postexposure prophylaxis:
44 kg or less: 2.2 mg/kg orally twice daily (maximum 200 mg/day) for 14 days
45 kg or more: 100 mg orally twice daily for 14 days

The Working Group on Civilian Biodefense has recommended doxycycline or ciprofloxacin for tularemia treatment or postexposure prophylaxis in a mass-casualty setting.

What other drugs will affect doxycycline?

Before taking doxycycline, tell your doctor if you are taking any of the following drugs:

• cholesterol-lowering medications such as cholestyramine (Prevalite, Questran) or colestipol (Colestid);

• isotretinoin (Accutane);

• tretinoin (Renova, Retin-A, Vesanoid);

• an antacid such as Tums, Rolaids, Milk of Magnesia, Maalox, and others;

• a product that contains bismuth subsalicylate such as Pepto-Bismol;

• minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements;

• a blood thinner such as warfarin (Coumadin); or

• a penicillin antibiotic such as amoxicillin (Amoxil, Trimox, others), penicillin (BeePen-VK, Pen-Vee K, Veetids, others), dicloxacillin (Dynapen), oxacillin (Bactocill), and others.

This list is not complete and there may be other drugs that can interact with doxycycline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about doxycycline.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 13.01. Revision Date: 07/29/2009 1:39:49 PM.