Methadone and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with methadone which include:
methadone ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using methadone together with ethanol, this can add to the side effects of methadone. In general, methadone should not be combined with alcohol. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol. Call your doctor if you have symptoms of extreme drowsiness, pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops. Avoid activities requiring mental alertness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
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methadone ↔ food
Moderate Food Interaction
Grapefruit juice can increase the blood levels and effects of methadone. If you regularly consume grapefruits or grapefruit juice, you should be monitored for side effects and/or changes in methadone levels. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Orange juice is not expected to interact.
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You should also know about...
methadone drug Interactions
There are 905 drug interactions with methadone
methadone disease Interactions
There are 16 disease interactions with methadone which include:
Impaired Gi Motility- Infectious Diarrhea
- Liver Disease
- Prematurity
- Renal Dysfunction
- Acute Alcohol Intoxication
- Drug Dependence
- Hypotension
- Intracranial Pressure
- Respiratory Depression
Adrenal Insufficiency- Biliary Spasm
- Hypothyroidism
- Seizure Disorders
- Urinary Retention
- Arrhythmias
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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