Tarceva (erlotinib) Alcohol, Food & Lifestyle Interactions

There is 1 food and lifestyle interaction with Tarceva (erlotinib):

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of erlotinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.

ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of erlotinib. According to product labeling, administration with food increased the oral bioavailability of erlotinib from approximately 60% to almost 100% compared to administration in the fasting state.

MANAGEMENT: Patients treated with erlotinib should preferably avoid consumption of grapefruit or grapefruit juice. Erlotinib should be administered at least one hour before or two hours after the ingestion of food.

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Tarceva (erlotinib) drug Interactions

There are 156 drug interactions with Tarceva (erlotinib)

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