Cilostazol and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with cilostazol.
Cilostazol Food
Moderate Food Interaction
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of cilostazol. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The extent and clinical significance are unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Until more information is available, the manufacturer recommends avoiding consumption of grapefruit juice during cilostazol therapy. Orange juice is not expected to interact with cilostazol.
References
- (2001) "Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals Inc
Cilostazol drug interactions
There are 453 drug interactions with cilostazol.
Cilostazol disease interactions
There are 4 disease interactions with cilostazol which include:
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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