Methadone Drug Interactions
Currently displaying 390 drugs known to have a moderate interaction with methadone.
Moderate interactions with methadone
Note: Showing generic names only.
5
A
- abacavir
- abametapir topical
- acebutolol
- acrivastine
- adalimumab
- albuterol
- aldesleukin
- alefacept
- alfentanil
- allopurinol
- almotriptan
- alpelisib
- amifampridine
- amiloride
- amlodipine
- amphetamine
- amprenavir
- amyl nitrite
- anakinra
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- arformoterol
- asciminib
- atenolol
- atropine
- attapulgite
- avacopan
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baricitinib
- belladonna
- benazepril
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- berotralstat
- betaxolol
- bexarotene
- bimekizumab
- binimetinib
- biperiden
- bisacodyl
- bismuth subgallate
- bismuth subsalicylate
- bisoprolol
- bitolterol
- blinatumomab
- boceprevir
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
C
- canakinumab
- candesartan
- cannabidiol
- capivasertib
- captopril
- carbetapentane
- carbinoxamine
- carvedilol
- casanthranol
- cascara sagrada
- castor oil
- certolizumab
- cetirizine
- cevimeline
- chlophedianol
- chloramphenicol
- chlorcyclizine
- chlorothiazide
- chlorpheniramine
- chlorthalidone
- cimetidine
- clemastine
- clevidipine
- clidinium
- clonidine
- clopidogrel
- clotrimazole
- conivaptan
- cyclizine
- cyclosporine
- cyproheptadine
D
- danazol
- darifenacin
- darunavir
- deferasirox
- delavirdine
- desflurane
- desmopressin
- desvenlafaxine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dextromethorphan
- diazoxide
- dicyclomine
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- doxazosin
- doxylamine
- dronabinol
- duloxetine
- duvelisib
E
- echinacea
- efavirenz
- elafibranor
- eletriptan
- elranatamab
- eluxadoline
- emapalumab
- enalapril
- enalaprilat
- enflurane
- entacapone
- epcoritamab
- eplerenone
- eprosartan
- esmolol
- etanercept
- ethanol
- ethosuximide
- ethotoin
- etravirine
F
- famotidine
- fedratinib
- felbamate
- felodipine
- fenfluramine
- flavoxate
- flibanserin
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- fosinopril
- fospropofol
- fostamatinib
- frovatriptan
- furosemide
G
- galantamine
- ganaxolone
- ginkgo
- givosiran
- glofitamab
- glycerin
- glycerol phenylbutyrate
- glycopyrrolate
- golimumab
- griseofulvin
- guanethidine
- guanfacine
- guselkumab
H
I
- idelalisib
- ifosfamide
- imatinib
- indacaterol
- indapamide
- indocyanine green
- infliximab
- irbesartan
- isavuconazonium
- isoetharine
- isoflurane
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- ixekizumab
K
L
- labetalol
- lactitol
- lactulose
- lamotrigine
- larotrectinib
- lasmiditan
- lenacapavir
- lesinurad
- letermovir
- levalbuterol
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomilnacipran
- lidocaine
- lindane topical
- lisinopril
- lonafarnib
- lonapegsomatropin
- loperamide
- losartan
M
- magnesium citrate
- magnesium hydroxide
- mazindol
- mebrofenin
- meclizine
- melatonin
- mepenzolate
- mephenytoin
- methamphetamine
- methdilazine
- methohexital
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- metoclopramide
- metolazone
- metoprolol
- metreleptin
- metronidazole
- metyrosine
- mibefradil
- miconazole
- midazolam
- milnacipran
- mineral oil
- minoxidil
- mitapivat
- moexipril
- mosunetuzumab
N
- nabilone
- nadolol
- naloxone
- naratriptan
- nebivolol
- nefazodone
- nelfinavir
- nevirapine
- nicardipine
- nifedipine
- nimodipine
- nirogacestat
- nisoldipine
- nitisinone
- nitroglycerin
- nitroprusside
- nitrous oxide
O
- olaparib
- olmesartan
- olodaterol
- olopatadine nasal
- omaveloxolone
- opicapone
- opium
- oritavancin
- oxybutynin
P
- palbociclib
- paramethadione
- paroxetine
- peginterferon alfa-2b
- pegvisomant
- perampanel
- pergolide
- perindopril
- phenacemide
- phenindamine
- phenolphthalein
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylbutazone
- pindolol
- pirbuterol
- pirtobrutinib
- polyethylene glycol 3350
- polythiazide
- pralsetinib
- pramipexole
- prasugrel
- prazosin
- procyclidine
- propantheline
- propofol
- propranolol
- pyrilamine
Q
R
- ramipril
- remifentanil
- reserpine
- rilonacept
- ritlecitinib
- ritonavir
- rivastigmine
- rizatriptan
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rufinamide
S
- salmeterol
- sarilumab
- satralizumab
- scopolamine
- secukinumab
- senna
- sibutramine
- sildenafil
- silodosin
- siltuximab
- sirolimus
- sodium polystyrene sulfonate
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sumatriptan
T
- tacrine
- talquetamab
- tamsulosin
- tarlatamab
- tazemetostat
- tebentafusp
- teclistamab
- tecovirimat
- telaprevir
- telmisartan
- temsirolimus
- terazosin
- thalidomide
- thiethylperazine
- thiopental
- tiagabine
- ticagrelor
- timolol
- timolol ophthalmic
- tirzepatide
- tocilizumab
- tofacitinib
- tolcapone
- tolterodine
- topiramate
- torsemide
- tovorafenib
- trandolapril
- triamterene
- trihexyphenidyl
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- trospium
- tryptophan
- tucatinib
U
V
- valerian
- valproic acid
- valsartan
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vonoprazan
- vortioxetine
- voxelotor
Z
Methadone alcohol/food interactions
There are 2 alcohol/food interactions with methadone.
Methadone disease interactions
There are 16 disease interactions with methadone which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.