Targretin Dosage

Generic name: bexarotene
Dosage form: capsule, liquid filled

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

The recommended initial dose of Targretin capsules is 300 mg/m2/day. (See Table 4.) Targretin capsules should be taken as a single oral daily dose with a meal. See CONTRAINDICATIONS: Pregnancy: Category X section for precautions to prevent pregnancy and birth defects in women of child-bearing potential.

Table 4. Targretin Capsule Initial Dose Calculation According to Body Surface Area

Initial Dose Level (300 mg/m2/day)

Number of 75 mg Targretin Capsules

Body Surface Area (m2)

Total Daily Dose (mg/day)

0.88 - 1.12

300

4

1.13 - 1.37

375

5

1.38 - 1.62

450

6

1.63 - 1.87

525

7

1.88 - 2.12

600

8

2.13 - 2.37

675

9

2.38 - 2.62

750

10

Dose Modification Guidelines: The 300 mg/m2/day dose level of Targretin capsules may be adjusted to 200 mg/m2/day then to 100 mg/m2/day, or temporarily suspended, if necessitated by toxicity. When toxicity is controlled, doses may be carefully readjusted upward. If there is no tumor response after eight weeks of treatment and if the initial dose of 300 mg/m2/day is well tolerated, the dose may be escalated to 400 mg/m2/day with careful monitoring.

Duration of Therapy: In clinical trials in CTCL, Targretin capsules were administered for up to 97 weeks.

Targretin capsules should be continued as long as the patient is deriving benefit.

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