Phendimetrazine Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Obesity

One Slow Release Capsule (105 mg) in the morning, taken 30 to 60 minutes before the morning meal.

Immediate release: 35 mg oral tablet 2 to 3 times daily, 1 hour before meals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Tolerance to the anorectic effect usually develops within a few weeks. When this occurs, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued.

Precautions

Phendimetrazine tartrate is contraindicated for use in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate or severe hypertension, hyperthyroidism, and/or glaucoma. The drug is also contraindicated for use in agitated states or in patients with a history of drug abuse.

Caution is recommended when prescribing phendimetrazine tartrate for patients with even mild hypertension.

Stimulant drugs have been extensively abused, and the possibility of abuse of phendimetrazine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. Abuse may be associated with intense psychological dependence and severe social dysfunction.

Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes.

Dialysis

Data not available

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