Iron Dextran Dosage
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Iron Deficiency Anemia
25 to 100 mg (0.5 to 2 mL) IM or IV once a day. Individual doses of 100 mg (2 mL) may be given by the intermittent IM or IV route until the calculated total iron dextran requirement has been met.
Total dose infusion method: The total dose required is diluted in 250 to 1000 mL of normal saline and administered over a 2 to 6 hour period. Upon completion of the infusion, the vein should be flushed with 10 mL of normal saline.
Usual Adult Dose for Anemia Associated with Chronic Renal Failure
25 to 100 mg (0.5 to 2 mL) IM or IV once a day. Patients with low baseline iron profiles at the beginning of epoetin alfa therapy should be supplemented with oral (preferred) or parenteral iron therapy to insure adequate erythropoiesis.
Renal Dose Adjustments
Data not available; however, caution is recommended when administering this drug to patients with renal impairment.
Liver Dose Adjustments
The manufacturer recommends use with extreme caution in patients with liver dysfunction.
Total iron dextran requirements for iron deficiency anemia may be calculated using the following equation in adults over 15 kg:
Total dose of iron dextran (in mL) = 0.0442 (desired hemoglobin [g/L] - observed hemoglobin [g/L] x ideal body weight + (0.26 x ideal body weight). If the patient weighs < 15 kg, actual body weight should be used.
All patients should receive a 25 mg (0.5 mL), 12.5 mg (0.25 mL) for infants, test dose over at least 30 seconds IM or IV prior to initiation of the therapeutic dose. An interval of at least 1 hour is recommended between the test dose and the remainder of the therapeutic dose. Observe the patient closely for anaphylaxis. Epinephrine, IV diphenhydramine, methylprednisolone and oxygen should be available for immediate use. Iron dextran should be used with extreme caution in patients with liver dysfunction.
Iron dextran is not appreciably removed by hemodialysis. Supplemental dosing following hemodialysis is not necessary.
Data not available on the use of iron dextran during peritoneal dialysis.
The maximum daily dose should not exceed 100 mg (2 mL). If given by intermittent IV injection, the rate should not exceed 1 mL (50 mg)/min. Evaluations of hematologic laboratory parameters (serum ferritin, hemoglobin, reticulocyte count, hematocrit) should be made periodically.
In patients experiencing a hypersensitivity reaction to iron dextran, use of iron sucrose may be a safer alternative.