Iron dextran Pregnancy and Breast Feeding Warnings
Iron dextran is also known as: Dexferrum, Infed
Overview
It is unknown if Iron Dextran can cause harm to the fetus. If you become pregnant while taking Iron Dextran , discuss with your doctor the benefits and risks of using Iron Dextran during pregnancy. Iron Dextran is excreted in breast milk. If you are or will be breast-feeding while you are using Iron Dextran , check with your doctor or pharmacist to discuss the risks to your baby.
Iron dextran Pregnancy Warnings
Iron dextran has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of embryolethality and teratogenicity. There are no controlled data in human pregnancy. Iron dextran should only be given during pregnancy when there are no alternatives and benefit outweighs risk.
Teratogenic and embryocidal effects have occurred when iron dextran was given to laboratory animals at 3 times the maximum recommended human dose. Additionally, toxicity has been reported with doses ranging from 125 mg/kg of elemental iron as a single dose to a total intravenous dose of 90 mg/kg of elemental iron over a 14 day period. However, no consistent adverse fetal effects were observed at doses of 50 mg/kg of elemental iron or less. The animals used in these laboratory tests were not iron deficient. Small amounts of iron cross the placenta, however, the form in which it crosses is not known. Neonatal serum iron concentrations have increased when iron dextran was administered within 2 weeks of delivery. No adverse effects were reported.
Iron dextran Lactation Warnings
Traces of unmetabolized iron dextran are excreted into human milk. However, adverse effects in infants have not been reported. Iron dextran should be administered with caution during breast-feeding.
Zavaleta and colleagues found that oral iron sulfate given to anemic women after delivery did not effect milk iron or lactoferrin concentrations.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
