Dexmethylphenidate Dosage

This dosage information may not include all the information needed to use Dexmethylphenidate safely and effectively. See additional information for Dexmethylphenidate.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Attention Deficit Disorder

Extended-release:

Patients currently not involved in treatment with dexmethylphenidate, racemic methylphenidate, or other stimulants:
Initial: 10 mg once a day (in the morning)
Maintenance: Dosage may be adjusted in 10 mg increments at approximately weekly intervals.
Maximum dose: 40 mg/day

Patients currently involved in treatment with methylphenidate:
Initial: one-half the total daily dose of racemic methylphenidate
Maximum dose: 40 mg/day

Patients currently taking dexmethylphenidate immediate-release:
Initial dose: dose equal to the daily dose of immediate-release administered once a day (in the morning).
Maximum dose: 40 mg/day

Usual Pediatric Dose for Attention Deficit Disorder

Immediate-release:
6 to 18 years:
Patients not currently taking racemic methylphenidate or other stimulants:
Initial: 2.5 mg twice a day, with an interval of at least 4 hours between doses.
Maintenance: Dosage may be adjusted in 2.5 to 5 mg increments at approximately weekly intervals.
Maximum dose: 10 mg twice a day

Patients currently taking methylphenidate:
Initial: one-half the dose of racemic methylphenidate.
Maximum dose: 10 mg twice a day.

Extended-release:
6 to 18 years:
Patients not currently taking dexmethylphenidate, racemic methylphenidate, or other stimulants:
Initial: 5 mg once a day (in the morning)
Maintenance: Dosage may be adjusted in 5 mg increments at approximately weekly intervals.
Maximum dose: 30 mg per day

Patients currently taking methylphenidate:
Initial: one-half the dose of racemic methylphenidate.
Maximum dose: 30 mg per day

Patients currently taking dexmethylphenidate immediate-release:
Initial dose: dose equal to the daily dose of immediate-release administered once a day (in the morning).
Maximum dose: 30 mg per day

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Dosage adjustments should be individualized in accordance with the needs and response of the patient.

The patient should be observed for a sufficient amount of time at a given dose prior to dosage adjustments to ensure a maximal benefit has been achieved.

The dosage should be reduced or discontinued in the presence of paradoxical aggravation of symptoms or occurrence of serious side effects. If after appropriate dosage adjustment over a one-month period improvement is not observed the drug should be discontinued.

Precautions

Sufficient data regarding the long-term effects of dexmethylphenidate on growth in children are not yet available. However, suppression of growth (that is, weight gain, and/or height) has been reported with the long-term use of stimulants in children. Although a causal relationship has not been established, patients requiring long-term therapy should be monitored and therapy interrupted if the rate of growth and weight gain is not as expected.

It is recommended to avoid use of stimulants, including dexmethylphenidate, in patients with known structural cardiac abnormalities as cases of sudden death, primarily in children, have been reported.

There are no sufficient data on the long-term use of dexmethylphenidate in pediatric patients (less than 18 years of age).

Safety and effectiveness has not been established in pediatric patients less than 6 years of age.

The use of dexmethylphenidate immediate-release in adults with ADHD is not approved by the FDA.

Dialysis

Data not available

Other Comments

Dexmethylphenidate extended-release capsules may be swallowed whole or contents may be sprinkled on a small amount of applesauce. The mixture of drug and applesauce should be immediately consumed in its entirety and not stored for future use.

Periodic complete blood count (CBC), differential, and platelet counts are recommended during prolonged therapy.

There is no data on the effectiveness or safety dexmethylphenidate for long-term use (longer than 7-weeks) in patients with ADHD. Most clinicians agree that pharmacological treatment of ADHD may be necessary for extended periods of time. However, the use of dexmethylphenidate should be evaluated on a periodic basis to determine the long-term usefulness for the patient with periods off medication to assess functioning without pharmacotherapy.

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