Clotrimazole Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Oral Thrush

Treatment: 10 mg troche orally 5 times a day for 14 days.

Prophylaxis: 10 mg orally 3 times a day for immunosuppressed patients that include chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation. Continue treatment for the duration of chemotherapy or until steroids are reduced to maintenance levels.

Usual Pediatric Dose for Oral Thrush

Greater than 3 years:

Treatment: 10 mg troche orally 5 times a day for 14 days.

Prophylaxis: 10 mg orally 3 times a day for immunosuppressed patients that include chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation. Continue treatment for the duration of chemotherapy or until steroids are reduced to maintenance levels.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Clotrimazole troches are not indicated for the local treatment of systemic mycosis including systemic candidiasis.

Abnormal liver function tests have been reported in patients receiving clotrimazole troches. Elevated SGOT levels were reported in patients in clinical trials. In most cases, the elevations were minimal and often impossible to distinguish from those of other therapy and the underlying disease (malignancy in most cases). Periodic assessment of hepatic function is recommended particularly in patients with pre-existing hepatic impairment.

Since patients must be instructed to allow each troche to dissolve slowly in the mouth in order to achieve maximum effect of the drug, they must be of such an age and physical and/or mental condition to comprehend such instructions.

If sensitivity or irritation develops with the use of clotrimazole, treatment should be discontinued.

Notify the prescribing physician if after four weeks of treatment there is no improvement.
Clinical studies of clotrimazole did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Other reported clinical experience with clotrimazole has not identified differences in responses between elderly and younger patients.

Dialysis

Data not available

Other Comments

Clotrimazole troches should be dissolved slowly in the mouth, over 15-30 minutes.

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