Macrobid (nitrofurantoin) Disease Interactions

There are 4 disease interactions with Macrobid (nitrofurantoin):

Nitrofurantoin (Includes Macrobid) ↔ G-6-Pd Deficiency

Severe Potential Hazard, High plausibility

Applies to: G-6-PD Deficiency

Hemolytic anemia has been reported in patients treated with nitrofurantoin, primarily in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Therapy with nitrofurantoin should be avoided or administered cautiously in patients with G-6-PD deficiency. The development of hemolysis is an indication for withdrawal of nitrofurantoin therapy. Hemolysis ceases when the drug is withdrawn.

References

  1. "Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
  2. "Product Information. Macrodantin (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.

Nitrofurantoin (Includes Macrobid) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

The use of nitrofurantoin is contraindicated in patients with anuria, oliguria, or significant renal impairment (CrCl < 60 mL/min). Urinary concentration of the drug is likely to be inadequate in these patients, increasing the risk of therapeutic failure. Since nitrofurantoin is eliminated by the kidney, risk of toxicity may also be increased.

References

  1. Schirmeister J, Stefani F, Willmann H, Hallauer W "Renal handling of nitrofurantoin in man." Chemotherapy 5 (1965): 223-6
  2. Glascock HW, Jr "Nitrofurantoin in renal failure." Ann Intern Med 69 (1968): 1077
  3. "Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
View all 6 references

Nitrofurantoin (Includes Macrobid) ↔ Hepatotoxicity

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The use of nitrofurantoin has rarely been associated with hepatotoxicity, including hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis. Most acute reactions are self-limiting and resolve spontaneously, although fatalities have been reported. Therapy with nitrofurantoin should be administered cautiously in patients with liver disease. Periodic monitoring of liver function is recommended during prolonged therapy. The drug should be withdrawn immediately if hepatitis or liver damage occurs and is felt to be drug-related. Since nitrofurantoin is partially metabolized by the liver, a reduced dosage may also be necessary to prevent toxicity.

References

  1. Mollison LC, Angus P, Richards M, Jones RM, Ireton J "Hepatitis due to nitrofurantoin." Med J Aust 156 (1992): 347-9
  2. Sippel PJ, Agger WA "Nitrofurantoin-induced granulomatous hepatitis." Urology 18 (1981): 177-8
  3. "Product Information. Macrodantin (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
View all 14 references

Nitrofurantoin (Includes Macrobid) ↔ Peripheral Neuropathy

Moderate Potential Hazard, Moderate plausibility

Applies to: Diabetes Mellitus, Anemia Associated with Vitamin B12 Deficiency, Folic Acid/Cyanocobalamin Deficiency, Electrolyte Abnormalities, Hypocalcemia, Peripheral Neuropathy

The use of nitrofurantoin has occasionally been associated with the development of peripheral neuropathy, which may be severe and irreversible. Patients at risk include the elderly and those with renal impairment, anemia, diabetes mellitus, electrolyte imbalance, vitamin B12 deficiency, diabetes, and/or debilitating diseases. Therapy with nitrofurantoin should be administered cautiously in patients with one or more risk factors and/or preexisting peripheral neuropathy. Periodic monitoring of renal function is recommended during prolonged therapy.

References

  1. Craven RS "Furadantin neuropathy." Aust N Z J Med 3 (1971): 246-9
  2. Yiannikas C, Pollard JD, McLeod JG "Nitrofurantoin neuropathy." Aust N Z J Med 11 (1981): 400-5
  3. White WT, Harrison L, Dumas J "Nitrofurantoin unmasking peripheral neuropathy in a type 2 diabetic patient." Arch Intern Med 144 (1984): 821

You should also know about...

Macrobid (nitrofurantoin) drug Interactions

There are 222 drug interactions with Macrobid (nitrofurantoin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2014 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web3)