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Naldemedine Disease Interactions

There are 3 disease interactions with naldemedine.

Major

Naldemedine (applies to naldemedine) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of naldemedine should be avoided in patients with severe hepatic impairment. No dose adjustment is required in patients with mild or moderate hepatic impairment.

References

  1. (2017) "Product Information. Symproic (naldemedine)." Shionogi USA Inc
Major

Peripheral opioid receptor antagonists (applies to naldemedine) intestinal obstruction

Major Potential Hazard, Moderate plausibility. Applicable conditions: Diverticulitis, Peptic Ulcer, Inflammatory Bowel Disease, Gastrointestinal Obstruction

Peripheral opioid receptor antagonists are contraindicated in patients with known or suspected gastrointestinal obstruction, and in patients at increased risk of recurrent obstruction, due to the potential for gastrointestinal perforation. Cases of gastrointestinal perforation have been reported in patients with opioid-induced constipation and advanced illness with conditions that may be associated with localized or diffuse reduction of structure integrity in the wall of the GI tract such as peptic ulcer, diverticular disease, Crohn's disease, infiltrative GI tract malignancies or peritoneal metastases. It is recommended to monitor for the development of severe, persistent, or worsening abdominal pain and to discontinue treatment in patients who develop symptoms. The overall risk- benefit profile should be carefully evaluated before using these agents in patients with these conditions.

References

  1. (2008) "Product Information. Relistor (methylnaltrexone)." Wyeth Laboratories
  2. (2014) "Product Information. Movantik (naloxegol)." Astra-Zeneca Pharmaceuticals
  3. (2017) "Product Information. Symproic (naldemedine)." Shionogi USA Inc
Moderate

Naldemedine (applies to naldemedine) hemodialysis

Moderate Potential Hazard, Moderate plausibility.

Naldemedine is not removed from the blood by hemodialysis. Plasma concentrations of naldemedine in subjects with ESRD requiring hemodialysis were similar when the drug was administered either pre- or post-hemodialysis.

References

  1. (2017) "Product Information. Symproic (naldemedine)." Shionogi USA Inc

Naldemedine drug interactions

There are 167 drug interactions with naldemedine.

Naldemedine alcohol/food interactions

There is 1 alcohol/food interaction with naldemedine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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