Naldemedine Dosage

Medically reviewed by Drugs.com. Last updated on Mar 29, 2024.

Usual Adult Dose for Constipation - Drug Induced

0.2 mg orally once a day

Comments:

• Opioid analgesic doses do not require adjustments when starting this drug.
• Treatment should be discontinued if opioid pain medication is discontinued.

Use: Treatment of opioid-induced constipation (OIC) in patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Mild and moderate liver dysfunction (Child-Pugh class A and B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh class C): Not recommended.

Dose Adjustments

Suspicion of obstruction/perforation in patients with severe, persistent, and/or worsening abdominal pain: This drug should be discontinued.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or to any of the ingredients
• Patients at risk of recurrent obstruction
• Patients with known/suspected gastrointestinal obstruction

Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug may be taken without regard to meals; however, the dose should be taken at the same time each day.

Storage requirements:

• Protect from light and moisture.

General:

• Patients receiving opioids for less than 4 weeks prior to starting this drug may be less responsive.
• Changes to opioid analgesics are not required prior to starting this drug.
• This drug should be discontinued if treatment with the opioid pain medication is discontinued.

Monitoring:

• GASTROINTESTINAL: Abdominal pain
• OTHER: Opioid withdrawal signs/symptoms

Patient advice:

• Patients should be instructed to stop this drug if they stop taking their opioid pain medication.
• Patients should be instructed to promptly stop this drug and seek medical attention if they develop unusually severe, persistent, or worsening abdominal pain.
• Patients should be instructed to contact their healthcare professional if they experience opioid withdrawal symptoms.
• Patients should be instructed to speak with a healthcare professional before taking any new or over-the-counter medications, or herbal supplements, as other medications may affect the way this drug works.
• Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Frequently asked questions

• Which drugs cause opioid-induced constipation?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer