Lantus Solostar (insulin glargine) Disease Interactions
There are 2 disease interactions with Lantus Solostar (insulin glargine):
Insulin (Includes Lantus Solostar) ↔ Renal/Liver Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction, Liver Disease
Insulin requirements may be diminished in patients with renal or hepatic impairment due to reduced insulin metabolism and, in the latter case, also to reduced capacity for gluconeogenesis. Lower initial dosages may be appropriate, with careful monitoring of plasma glucose levels and dosing adjustments.
- "Product Information. Novolog (insulin aspart)" Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
- "Product Information. Lantus (insulin glargine)" Aventis Pharmaceuticals, Swiftwater, PA.
- "Product Information. Humulin BR (insulin)." Lilly, Eli and Company, Indianapolis, IN.
Insulin/Oral Hypoglycemic Agents (Includes Lantus Solostar) ↔ Hypoglycemia
Moderate Potential Hazard, High plausibility
Applies to: Adrenal Insufficiency, Anorexia/Feeding Problems, Autonomic Neuropathy, Malnourished, Panhypopituitarism
Hypoglycemia may commonly occur during treatment with insulin and/or oral hypoglycemic agents. Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during the use of these drugs, including those who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents.
- "Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY.
- Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
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Lantus Solostar (insulin glargine) drug Interactions
There are 830 drug interactions with Lantus Solostar (insulin glargine)
Lantus Solostar (insulin glargine) alcohol/food Interactions
There is 1 alcohol/food interaction with Lantus Solostar (insulin glargine)
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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