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hydrocodone and ibuprofen (Oral route)

hye-droe-KOE-done bye-TAR-trate, eye-bue-PROE-fen

Commonly used brand name(s):

In the U.S.

Ibudone
Reprexain
Vicoprofen

Available Dosage Forms:

Tablet

Therapeutic Class: Opioid/NSAID Combination

Pharmacologic Class: NSAID

Chemical Class: Hydrocodone

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Uses For hydrocodone and ibuprofen

Hydrocodone and ibuprofen combination is used to relieve pain.

The hydrocodone is a narcotic analgesic that acts in the central nervous system to relieve pain. If hydrocodone is used for a long time, it may become habit-forming (causing mental or physical dependence). Physical dependence may lead to withdrawal side effects when you stop taking the medicine. Since hydrocodone and ibuprofen combination is only used for short-term (10 days or less) relief of pain, physical dependence will probably not occur.

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in this combination to relieve inflammation, swelling, and pain.

hydrocodone and ibuprofen is available only with your doctor's prescription.

Before Using hydrocodone and ibuprofen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For hydrocodone and ibuprofen, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to hydrocodone and ibuprofen or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on hydrocodone and ibuprofen have been done only in adult patients, and there is no specific information comparing use of hydrocodone and ibuprofen combination in children with its use in other age groups.

Geriatric

Elderly people are especially sensitive to the effects of hydrocodone and ibuprofen combination. This may increase the chance of side effects during treatment. Constipation may be especially likely to occur in elderly patients.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using hydrocodone and ibuprofen with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ketorolac
Naltrexone

Using hydrocodone and ibuprofen with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adinazolam
Alfentanil
Alprazolam
Amobarbital
Anileridine
Aprobarbital
Ardeparin
Beta Glucan
Bromazepam
Brotizolam
Buprenorphine
Butabarbital
Butalbital
Butorphanol
Carisoprodol
Certoparin
Chloral Hydrate
Chlordiazepoxide
Chlorzoxazone
Clobazam
Clonazepam
Clorazepate
Codeine
Dalteparin
Danaparoid
Dantrolene
Dezocine
Diazepam
Enoxaparin
Estazolam
Ethchlorvynol
Fentanyl
Flunitrazepam
Flurazepam
Fospropofol
Ginkgo
Halazepam
Hydrocodone
Hydromorphone
Ketazolam
Levorphanol
Lorazepam
Lormetazepam
Medazepam
Meperidine
Mephenesin
Mephobarbital
Meprobamate
Metaxalone
Methocarbamol
Methohexital
Methotrexate
Midazolam
Morphine
Morphine Sulfate Liposome
Nadroparin
Nalbuphine
Nitrazepam
Nordazepam
Opium
Oxazepam
Oxycodone
Oxymorphone
Parnaparin
Pemetrexed
Pentazocine
Pentobarbital
Phenobarbital
Prazepam
Propoxyphene
Quazepam
Remifentanil
Reviparin
Secobarbital
Sodium Oxybate
Sufentanil
Tacrolimus
Tapentadol
Temazepam
Thiopental
Tinzaparin
Triazolam

Using hydrocodone and ibuprofen with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetohexamide
Alacepril
Amikacin
Amiloride
Aspirin
Azosemide
Bemetizide
Benazepril
Bendroflumethiazide
Benzthiazide
Bumetanide
Buthiazide
Candesartan Cilexetil
Canrenoate
Captopril
Chlorothiazide
Chlorpropamide
Chlorthalidone
Cilazapril
Citalopram
Clopamide
Clopidogrel
Clovoxamine
Cyclopenthiazide
Cyclosporine
Cyclothiazide
Delapril
Desipramine
Desvenlafaxine
Duloxetine
Enalaprilat
Enalapril Maleate
Eprosartan
Escitalopram
Ethacrynic Acid
Femoxetine
Flesinoxan
Fluoxetine
Fluvoxamine
Fosinopril
Furosemide
Gliclazide
Glimepiride
Glipizide
Gliquidone
Glyburide
Hydrochlorothiazide
Hydroflumethiazide
Imidapril
Indapamide
Irbesartan
Lisinopril
Lithium
Losartan
Methyclothiazide
Metolazone
Milnacipran
Moexipril
Nefazodone
Olmesartan Medoxomil
Paroxetine
Pentopril
Perindopril
Phenytoin
Piretanide
Polythiazide
Quinapril
Quinethazone
Ramipril
Sertraline
Spirapril
Spironolactone
Tacrine
Tasosartan
Telmisartan
Temocapril
Tolazamide
Tolbutamide
Torsemide
Trandolapril
Triamterene
Trichlormethiazide
Valsartan
Venlafaxine
Xipamide
Zimeldine
Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of hydrocodone and ibuprofen

For safe and effective use of hydrocodone and ibuprofen, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your health care professional. Taking too much of hydrocodone and ibuprofen may increase the chance of unwanted effects.

Dosing

The dose of hydrocodone and ibuprofen will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of hydrocodone and ibuprofen. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For pain:
  - Adults—1 tablet of Vicoprofen every four to six hours as needed.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of hydrocodone and ibuprofen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using hydrocodone and ibuprofen

Hydrocodone and ibuprofen combination will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, sleeping medicine, or other prescription pain medication. Do not drink alcoholic beverages, and check with your medical doctor or dentist before taking any of the medicines listed above, while you are using hydrocodone and ibuprofen.

hydrocodone and ibuprofen may cause some people to become drowsy, dizzy, or lightheaded, or to feel a false sense of well-being. Make sure you know how you react to hydrocodone and ibuprofen before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded. If these reactions are especially bothersome, check with your doctor.

Dizziness, lightheadedness, or fainting may occur, especially when getting up suddenly from a lying or sitting position. Getting up slowly may lessen this problem.

Serious side effects can occur during treatment with hydrocodone and ibuprofen. Sometimes serious side effects can occur without any warning. However, possible warning signs often occur, including swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, or unusual flushing or warmth of skin. Stop taking hydrocodone and ibuprofen and check with your doctor immediately if you notice any of these warning signs.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking hydrocodone and ibuprofen.

Hydrocodone and ibuprofen combination may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

hydrocodone and ibuprofen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Bloody stools
burning feeling in chest or stomach
congestion in chest
changes in facial skin color
cough
diarrhea
difficulty in swallowing
fast or irregular breathing
fever
frequent urge to urinate
heartburn
inability to urinate
irregular heartbeat
lightheadedness or dizziness
loss of bladder control
puffiness or swelling of the eyelids or around the eyes
ringing or buzzing in the ears
shortness of breath, troubled breathing, tightness in chest and/or wheezing
skin rash, hives, and/or itching
stomach pain
tenderness in stomach

Symptoms of overdose

Blurred vision
cold or clammy skin
confusion
difficulty hearing or ringing or buzzing in ears
dizziness
general feeling of illness
headache
mood or mental changes
nausea and/or vomiting
severe drowsiness
severe stomach pain
skin rash
slow heartbeat
slow or troubled breathing
stiff neck and/or back
swelling of the face, fingers, feet, or lower legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Anxiety
constipation
dry mouth
gas
increased sweating
nausea and/or vomiting
nervousness
pounding heartbeat
sleepiness
swelling of feet or lower legs
trouble in sleeping
unusual tiredness or weakness

Less common or rare

Confusion
decreased appetite
decrease in sexual ability
depression
headache
heartburn
increased thirst
irritability
mood or mental changes
mouth ulcers
pain or burning in throat
runny nose
sensation of burning, warmth, heat, numbness, tightness, or tingling
slurred speech
stomach upset
thinking abnormalities
trembling or shaking of hands or feet
unexplained weight loss
unusual feeling of well-being
visual disturbances

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

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