Hydrocodone/Ibuprofen Dosage

Usual Adult Dose for Pain

For short-term (generally less than 10 days) management of acute pain:
1 tablet every 4 to 6 hours as needed

Maximum dosage: 5 tablets in 24 hours

Renal Dose Adjustments

Treatment with hydrocodone-ibuprofen is not recommended in patients with advanced renal disease. If hydrocodone-ibuprofen therapy must be initiated, close monitoring of the patient's renal function is advisable.

Liver Dose Adjustments

Any patient with symptoms and/or signs suggesting liver dysfunction, or in whom an abnormal liver test has occurred, should be evaluated for evidence of the development of more severe hepatic reactions while on hydrocodone-ibuprofen therapy. If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g. eosinophilia, rash, etc.), then hydrocodone-ibuprofen should be discontinued.

Dose Adjustments

The lowest effective dose or the longest dosing interval should be sought for each patient, especially the elderly.

After observing the initial response of the patient to therapy with hydrocodone-ibuprofen, the dose and frequency should be adjusted to the individual patients need (without exceeding the total recommended daily dose).

Precautions

Warning: May be habit forming.

Tolerance to hydrocodone can develop with continued use and the incidence of untoward effects is dose related.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Treatment with hydrocodone-ibuprofen is not recommended in patients with advanced renal disease. If hydrocodone-ibuprofen therapy must be initiated, close monitoring of the patient's renal function is advisable.

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