ciprofloxacin and dexamethasone (Otic route)
sip-roe-FLOX-a-sin hye-droe-KLOR-ide, dex-a-METH-a-sone
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Anti-Infective/Anti-Inflammatory Combination
Pharmacologic Class: Adrenal Glucocorticoid
Chemical Class: Ciprofloxacin
Uses For ciprofloxacin and dexamethasone
Ciprofloxacin and dexamethasone is a combination of two medicines used to treat ear infections. One of the medicines is an antibiotic (medicine used to fight infection) and the other is a corticosteroid (cortisone-like medicine). The antibiotic (ciprofloxacin) is used to fight ear infections. The corticosteroid (dexamethasone) is used to relieve the redness, itching, and swelling caused by ear infections.
ciprofloxacin and dexamethasone is used to treat middle ear infection with drainage through a tube in children 6 months of age and older. A middle ear infection is an infection caused by bacteria behind the eardrum. People who have a tube in the eardrum may notice drainage from the ear canal.
ciprofloxacin and dexamethasone is also used to treat outer ear canal infections in patients 6 months of age or older. An outer ear canal infection, also known as “Swimmer's Ear,” is a bacterial infection of the outer ear canal. The ear canal and outer part of the ear may swell, turn red, and be painful. Also, a fluid discharge may appear in the ear canal.
ciprofloxacin and dexamethasone is available only with your doctor's prescription.
Before Using ciprofloxacin and dexamethasone
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ciprofloxacin and dexamethasone, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to ciprofloxacin and dexamethasone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
There is no specific information comparing use of ciprofloxacin and dexamethasone combination in children younger than 6 months of age with use in other age groups. ciprofloxacin and dexamethasone should not be used in children under 6 months of age.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work the same way they do in younger people of if they cause different side effects or problems in older people. It is not expected to cause different side effects or problems in older people than it does in younger adults.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ciprofloxacin and dexamethasone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ciprofloxacin and dexamethasone with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Rotavirus Vaccine, Live
Using ciprofloxacin and dexamethasone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Arsenic Trioxide
- Doxorubicin Hydrochloride Liposome
- Eslicarbazepine Acetate
- Insulin Aspart, Recombinant
- Insulin Bovine
- Insulin Degludec
- Insulin Detemir
- Insulin Glulisine
- Insulin Lispro, Recombinant
- Perflutren Lipid Microsphere
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Vincristine Sulfate Liposome
Using ciprofloxacin and dexamethasone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Lanthanum Carbonate
- Mycophenolate Mofetil
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using ciprofloxacin and dexamethasone with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use ciprofloxacin and dexamethasone, or give you special instructions about the use of food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of ciprofloxacin and dexamethasone. Make sure you tell your doctor if you have any other medical problems, especially:
- Viral ear infections (infections caused by a virus)—ciprofloxacin and dexamethasone should not be used in patients with viral ear infections of the outer ear canal.
Proper Use of ciprofloxacin and dexamethasone
ciprofloxacin and dexamethasone is to be used in the ear only. It is not approved for use in the eye. Do not take by mouth. If ciprofloxacin and dexamethasone is accidently swallowed call your doctor right away.
It is important that the infected ear(s) remain clean and dry. When bathing, avoid getting the infected ear(s) wet. Avoid swimming unless your doctor has instructed you otherwise.
- Wash hands thoroughly with soap and water
- Hold the bottle of ear drops in the hand for one or two minutes to warm the medicine, then shake well.
- Lie down on your side with your infected ear facing up.
- Put drops in infected ear.
- To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the ear). Also, keep the container tightly closed.
- For Patients with Middle Ear Infection with Tubes: While the person getting the ear drops lies on their side the person giving the drops should gently press the small projection in front of the outside opening of the ear 5 times in a pumping motion. This will allow the drops to pass through the tube and into the middle ear.
- For patients with Outer Ear Infection (“Swimmer's Ear”): While the person getting the ear drops lies on their side, the person giving the drops should gently pull the outer ear lobe upward and backward. This will allow the ear drops to flow down into the ear canal.
- The person who just had the ear drops should stay on their side for at least one minute. Repeat the above steps if both ears are infected.
- When you have completed your course of therapy (usually 7 days), throw away the medicine that you did not use.
To help clear up your infection completely, keep using ciprofloxacin and dexamethasone for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses. If the ear drops are not used for as long as the doctor recommended your infection can return.
The dose of ciprofloxacin and dexamethasone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of ciprofloxacin and dexamethasone. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For ear drops dosage form:
- For ear infections:
- Adults and children 6 months of age and older—Place four drops in the ear canal of infected ear two times a day for seven days.
- Children younger than 6 months of age—Use and dose must be determined by your doctor.
- For ear infections:
If you miss a dose of ciprofloxacin and dexamethasone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Precautions While Using ciprofloxacin and dexamethasone
If your symptoms do not improve within a week, or if they become worse, check with your doctor.
If you experience a rash or an allergic reaction to ciprofloxacin and dexamethasone, stop using it and call your doctor immediately.
ciprofloxacin and dexamethasone Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- Ear discomfort
- ear pain
- itching skin on the ear
- Bitter, sour or unusual taste in mouth
- ear congestion
- ear debris
- ear residue
- redness of skin
- superimposed ear infection (second ear infection)
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
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