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Zoloft for Depression User Reviews (Page 5)

Zoloft has an average rating of 6.8 out of 10 from a total of 585 reviews for the treatment of Depression. 57% of reviewers reported a positive experience, while 22% reported a negative experience.

Reviews for Zoloft

  • Summer
  • Taken for less than 1 month
  • March 17, 2019

"I have taken a few antidepressants just looking for perfect fit. DO NOT TAKE ZOLOFT my side effects were so severe I have been out of work for 2 weeks. Prozac was probably the best. My experience was so bad that I now take 0 meds because of the ill effects. I can give you pointers on natural remedies."

1 / 10
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  • Sarah
  • Taken for 1 to 6 months
  • September 5, 2018

"When my doctor prescribed me Zoloft I was scared of the side effects and put off taking it for a few days. Now I could not be happier that I started taking it though. I have been on 50mg for almost 5 weeks and have not noticed any side effects.... my depression has gotten so much better. I wake up excited about the day and just feel generally happy and nothing feels so difficult anymore. I haven’t cried once since starting the medication whereas beforehand I was crying every day and all I wanted to do was lay in bed. My friends and family as well as myself have all noticed a huge difference in me. I’m so happy with my progress on Zoloft so far. I am hoping that it helps improve my general and social anxiety soon because I have not seen much of an improvement there but I know it can take 8 weeks. Definitely recommend this medication and don’t be scared to start taking it! The side effects are rare and it will be the best decision of your life."

8 / 10
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  • Shann...
  • Taken for less than 1 month
  • September 4, 2016

"I have been on 50mg of Zoloft for a little over 3 weeks now. For the first week I noticed no change then gradually I was feeling better. It has given me more energy and i feel I have a more positive attitude. I was overeating a lot due to stress and depression that has completely subsided. Since I started taking it I have lost 19 pounds. That has also really helped with my depression. I am scared of my body getting used to it and go back to my regular habits. As for now I am happy."

10 / 10
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Frequently asked questions

  • jaybee
  • September 1, 2013

"I have been taking Zoloft for 8 weeks and the result has been amazing. The beginning was rocky with nausea, heavy head and fatigue, but it gets better. I am more confident, better at my job, I enjoy socializing far more, my relationship is saved and I generally feel more balanced. I have had anxiety since childhood and struck depression in late teens, am now 27. Not sure how long I will or should take Zoloft, but I am hugely relieved. "

8 / 10
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  • Blaze...
  • October 27, 2009

"I was prescribed Zoloft for depression. I had tried Wellbutrin and Lexapro in the past with little results. With Zoloft at first the side-effects were tough. Also, I was having sexual side-effects. Lacking desire (which is not normal for me), and the inability to achieve orgasm. I decided to try taking my pills in the morning, rather than at night like I had been doing. After a couple of days past on with my new schedule, the sexual side effects subsided and I'm back to normal with that. I never knew an anti-depressant could help so much, but it has REALLY helped me!"

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Are you taking this medicine?

  • Santa...
  • Taken for 1 to 6 months
  • March 23, 2024

"Zoloft is a life saver! I recently left my ex-husband, and I was going through some weird, scary emotions. I would be very anxious at times. My psychiatrist put me on Zoloft, 25 mg, and it took the scary, anxious feeling away. I'm not that heartbroken anymore. The only side effect I'm having is bad heartburn. I'm on 50 mg now, and I feel great."

10 / 10
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  • Bad...
  • February 3, 2020

"Thank you all for sharing your experiences. I was on Zoloft 10 years ago ( back in 2009), for 6-7 months only, took only a dose 50mg (started with 25mg) per day for mild depression ( or rather bad moods). It worked well for me and had no side effects, maybe I was drinking more water only (dry mouth feeling). I felt very happy - my mood was up , even maybe a little too high ( my friends noticed that as well), but I felt happier, also I became very brave :-) started to tell people things i would usually be afraid to do before. So my doctor smiled at me and said - congratulations , you are healthy now! So after 6 months I discontinued ( slowly dosage down), as I felt totally fine. I would love to take again this medicine, but I am very sad to read the reviews and wonder that they have changed the formula of Zoloft and side effects have gone worst :-(..is this is true? Why would they do that? Anyone could share their experience old zoloft and recent formula zoloft effects? Thanks"

8 / 10
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More FAQ

  • Milan
  • April 18, 2014

"After years of trying different medications sertraline has finally been the most useful and compatible one for me. If only I had found this years ago as it has lifted my depression, improved my social skills and eased my obsessive compulsive disorder symptoms (would trigger after anxiety)."

9 / 10
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  • anony...
  • February 2, 2014

"I'm 16, and over the course of a few months I started becoming more and more depressed and anxious, after trying a few other medications along with none at all (only therapy), I started taking Zoloft as it has helped others in my family. The first 10 days (started at 25mg) were horrible, suicidal thoughts, no appetite, headaches and terrible anxiety but once I hit 2 weeks I felt so much better. I'm now 6 weeks in and on 75mg, I feel amazing, still get headaches but I'm not sure if it's related, I feel almost 100% myself, I'll give it a few more weeks and see if I need to maybe get to 100mg but honestly this medication saved my life."

9 / 10
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  • Hope-...
  • Taken for 1 to 6 months
  • October 14, 2015

"I've been on Zoloft for 3 months now. Initially, I suffered from side effects such as shivering, loss of appetite, drowsiness, and insomnia. These symptoms lasted for about three days. I was scared at first and planned on trying another medication for anxiety. However, I called my cousin who is a nurse and she told me to try cutting the pill in half. I took my cousins advice and cut the pill in half, taking only 25mg a day which works really well for me.I'm 5'4, 130lbs. I no longer suffer from anxiety, after taking Zoloft that I realized that I was suffering from depression. Zoloft alleviates my anxiety and has greatly helped with my depression, I now feel more happy and motivated to do things right away without procrastinating. Life changer!"

10 / 10
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  • Weepsie
  • January 28, 2013

"Zoloft is amazing. I was put on Lexapro when I was about 18, gained about 20 lbs and felt like a numb zombie for about a year. Tried Celexa for about a year- a little better, but I was still getting very depressed. Then I tried Zoloft (50mg for a month and 100mg since). I've been on it for about 2 years. Depression and anxiety is minimal. I rarely have to use my Xanax. The only side effect I've had is dry mouth but it's minimal at worst. My appetite and sleep patterns are normal. As with the others I've tried, my sex drive is very low and I had moderate headaches for the first couple of weeks, so I won't pick on Zoloft for that. Overall, extremely satisfied, I can't imagine my life without it."

10 / 10
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  • Lizzy
  • Taken for 1 to 6 months
  • June 11, 2019

"I suffered from depression and anxiety along with other conditions and Zoloft severely lowered my feelings of depression and anxiety without any major negative side effects, unlike other antidepressants that caused me extreme fatigue and anger issues as side effects."

10 / 10
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  • Anxiety...
  • Taken for 1 to 6 months
  • January 18, 2014

"I started taking Zoloft about a month ago, in the first week i had some diarrhea and experienced some insomnia, but it soon disappeared. Within three weeks my depression and anxiety subsided. This medication changed my life."

7 / 10
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  • 40...
  • Taken for 1 to 6 months
  • July 19, 2017

"Got prescribed Zoloft after my 20 year relationship ended after my ex husband became addicted to meth. I was very depressed and couldn't control my thoughts about the situation, I had a hard time sleeping, zoning out, focusing, and adjusting to my normal everyday life. I started on 25 mg for about 3 weeks then increased to 50 mg. I've been on 50mg for a couple months and feel so much better. I can focus on my life again and never break down crying anymore etc. I had no side effects besides loose stool here and there. I like how there were no real side effects for me and it did what I was seeking. I would recommend to try Zoloft before other medications. I will not increase my dosage."

8 / 10
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  • Moham...
  • Taken for 6 months to 1 year
  • March 21, 2015

"Zoloft has been a lifesaver. Something that helps keep my crippling MDD and SAD at bay and make it through life normally. Even happier as this was the 1st antidepressant I tried and it worked! Also no side effects at all. Thank you God."

10 / 10
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  • Jenn...
  • Taken for 6 months to 1 year
  • July 16, 2015

"I think zoloft for me is great. The only downfall i have with it was headaches. They started right when I began taking zoloft daily. They were intense and hurt like hell. Lasted about 2 weeks. Then bam they were gone. I took it at night before bed. I thought they made me tired. Since I've been on it , I've lost about 20lbs. I don't have the munchies at all & honestly I have to tell myself to eat because it curbs my appetite. I don't feel bloated like I did on Lexapro that's why I switched. Zoloft really works for me and I'm on a low dose. Headaches suck the first few weeks but what a difference from lexapro. Everyone's different."

7 / 10
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  • Codr
  • Taken for 1 to 6 months
  • February 13, 2015

"This medicine completely changed my life. Before I got on it, I was in deep depression and had a horrible chemical imbalance in my brain. I have been on this medicine for 2 months. This is wonderful. Now I'm more happy, smiling, and the chemicals in my brain are balanced. I did gain 3 pounds since on this although it was supposed to decrease appetite."

10 / 10
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  • Anxiety...
  • Taken for 5 to 10 years
  • October 26, 2019

"This drug Zoloft changed my entire life. After years of use I tried to taper off. Took my time over months to taper off. Would prefer to not be on any drugs if possible. But anxiety and depression have returned. Will be starting back up this week. Have tried several times over the years to try without this drug. Always end up starting back up."

9 / 10
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  • jilly...
  • May 23, 2015

"Been taking 25mg zoloft for 2 weeks. Due to non stop over thinking, paranoia and constant checking up on suspected cheating partner. This drug has enabled me to think clearly again and be able to end an unhappy relationship that I could not end before. I don't react or panic at the thought of being on my own anymore. Its great to feel balanced and even keeled with my thoughts. No real side effects, although I am more motivated at home and don't seem to have a huge appetite so lost some weight. I like this drug, its given me some sanity again however I am worried about the symptoms returning if I stop taking it."

7 / 10
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  • Out...
  • Taken for less than 1 month
  • March 1, 2014

"I have been unemployed now for three years and things have gone from bad to worse. I found myself losing control of my temper and crying for no reason or if someone said something that negative. I couldn't sleep and when I did it was for two hours at a time. Sometimes I would stay up just crying. To add to my problems my back pain were getting worse. Doctor diagnose me with depression and gave me Zoloft. I started at 25mg for four days and then up to 50mg. It has been only a week, but I am not crying unexpectedly and feel calmer than I have in quite a while and have actually slept 5 hours straight. I had no side effects."

7 / 10
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  • torih...
  • April 4, 2008

"I was previously taking Lexapro for my major depression, but once I started having panic attacks, my doctor switched me to Zoloft. So far, the panic is gone, and my depression has similarly been suppressed. The only problem seems to be the side effects. I can't really eat that much anymore, and have succeeded in losing a fair amount of weight. I also have the "shakes" where my hands tremble. Though, as other people have said, the effectiveness of the medicine outweighs the side effects."

7 / 10
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180 Report
  • severe...
  • Taken for 1 to 6 months
  • November 19, 2016

"I was very very bad at one point with my anxieyy and depression and the OCD, they were all working together against me, the horrible disgusting thoughts from the OCD was driving me into constant panic attacks and anxiety through the roof! Which drove me to stay in doors and avoid triggers which then pushed me into a deep deep depression, I've been on zoloft now for about 6 months on a low dose of of 50mg, and I feel much better! I was able to go out and get a job which I am excelling at and got three raises in 4 months! I have felt a bit of the anxiety and ocd poking out once in a while but I may need to raise the dose but over all this med had changed my life so far, if you are in a rut and are down don't give up you can regain your life back!"

10 / 10
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  • Anon
  • June 13, 2018

"I wanted to share my experience to give people hope. Four months ago, I started having debilitating panic attacks almost daily, which then turned into a constant anxiety, not wanting to leave the house or do anything anymore, insomnia and the deepest depression I have ever known. I tried whatever I could to rid myself of it... meditation, therapy, self help books, diet, supplements. I had been very anti medication for myself. The first 3 days on Zoloft weren’t easy. I had insomnia, was shaky and felt agitated, zoning out and crying and crying. I am on day 4 now and I woke up this morning with the clearest mind. I haven’t felt like this in as long as I can remember. I feel so positive. I know it’s only early days but this gives me enormous hope. I am increasing my dose and pushing through any side effects. Don’t suffer endlessly as I have."

9 / 10
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  • Will
  • Taken for 1 to 6 months
  • October 28, 2021

"I’ve been suffering with Chronic Fatigue Syndrome for several years. Without this medication I would probably have ended my own life a while ago. My disease sucks, as it’s caused me to lose my career, friends, and social life. Two things are keeping me sane; my wife and Zoloft. The depressive thoughts and constant worry and anxiety about my condition has almost ceased thanks to this wonder drug. I’ve tested five other antidepressants that had little to no effect on me. For some reason, Zoloft works wonders. If you struggle from depression, do NOT give up on finding the right medication for you. There are so many options, and even though they claim to work similarly, they clearly don’t. Don’t give up. Keep fighting through. You are incredibly strong. I believe in you."

10 / 10
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  • prais...
  • March 20, 2008

"My postpartum depression, emotional outbursts, and anxiety was intense and Zoloft brought me immediate relief. In time, I felt that this medication provided me with a steady platform for me to function in life with. I can still cry, but my constant sadness is gone. I still feel emotion, but my uncontrollable outbursts ended. I can't seem to loose weight, but who knows if it is related to the Zoloft. I don't think I'll take Zoloft forever, but it sure has made a TREMENDOUS difference!"

10 / 10
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176 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.