Orphenadrine User Reviews & Ratings

Orphenadrine has an average rating of 6.7 out of 10 from a total of 81 reviews on Drugs.com. 60% of reviewers reported a positive experience, while 29% reported a negative experience.

Condition	Avg. Rating	Reviews	Compare
Migraine Off-label	6.4	11 reviews for Migraine	89 medications
Muscle Spasm	6.8	70 reviews for Muscle Spasm	57 medications
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Reviews for Orphenadrine

Nicho...
Taken for less than 1 month
June 25, 2016

Norflex (orphenadrine) for Muscle Spasm "After experiencing a nasty bulge disc , L5/6 and diagnosed with retro lethesis I spent 3 years from chiro to physio , but couldn't kick the intense pain in my back which would go all over my back. At times I'd be in bed for days. I saw a pain specialist and was given norflex. I took 100mg once a day and after 2 days I was pain free. I now only take it when it flares which isn't often. It changed my life for the better."

9 / 10

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152 Report

Gymbu...
Taken for less than 1 month
November 11, 2019

Norflex (orphenadrine) for Muscle Spasm "Worst medicine I have ever taken. I took two 100mg tablets and after 2 hours I couldn't read, focus or swallow. I had tremors that lasted two days and severe anxiety. I felt like I was completely paralysed, unable to lift my arms. No one warned me about the side effects and I had no idea it could be this bad."

1 / 10

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90 Report

Todd
Taken for less than 1 month
May 21, 2019

Norflex (orphenadrine) for Muscle Spasm "I had chronic lower back pain for several months which was muscle related and spread to my abdomen over time. I was prescribed Norlfex, first day it didn't do much, day 2 I took it again and then at the end of the day had a dissociative episode and the start of anxiety. Almost like a panic attack was about to kick off. I had battled anxiety for several years and weaned myself off Paroxetine nearly a decade and a half prior so it felt like it was all coming back. Googled after and found a side effect is...anxiety. Be careful if you are prone to this."

4 / 10

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76 Report

Bella...
June 9, 2015

Norflex (orphenadrine) for Muscle Spasm "I have 2 discs that press on my spine in my neck, as well as fibromyalgia, rheumatoid arthritis & an auto-immune disease. I recently came off of Methadone & Percocet, unintentionally, when I had just enough to get to my appointment with the pain specialist I was scheduled to see for the 1st time, but he got sick & they had to reschedule me. In addition to withdrawal, my pain level kept rising, to the point that every bone & muscle in my body hurt worse than I have ever been in!!! It's the only time I've ever used "9.9" to describe my pain! I have had to go to the ER several times in the last month. I was given Norflex 2 of those times, when I had a pinched nerve. Norflex helped SO MUCH MORE than ANY of the muscle relaxers I had at home!"

10 / 10

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113 Report

BSC
June 28, 2011

Norflex (orphenadrine) for Muscle Spasm "Had a herniated disc in between my L-5,S-1 vertebrae and had been prescribed Percocet for 7 months. Had 3 epidural steroid injections that worked for a while but then faded away. Finally had surgery and as a bodybuilder had a lot of muscle in my lower back to cut through to shave the disk off of the nerve. Was prescribed the Percocet still and Soma for muscle spasms and pain. All Soma did was make me pass out with little effect. Was currently changed to Norflex for the spasms and I only take 1 pill a day and it has done wonders without any side affects. Highly recommended for anyone with spasms or migraines."

9 / 10

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129 Report

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granny...
Taken for less than 1 month
February 15, 2013

Norflex (orphenadrine) for Muscle Spasm "I so grateful to find something to stop the spasms in my back! The spasms were coming about every 3 minutes much like labor pains! Pain killers were not working. Before taking Norflex, it took about a month to get through the spasms. I have been taking Norflex for the past three days and the relief is wonderful."

10 / 10

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113 Report

Gigi
Taken for less than 1 month
September 14, 2018

Norflex (orphenadrine) for Muscle Spasm "I have spina bifida with a lot of pain. I’m a former addict so I can’t take narcotics when the chronic pain is out of control. When I’m in bad shape my doc gives to shots (IM) of 60 mg of Norflex and 60 mg of toradol...and the two together work so well on my pain-and it lasts all day and I can FUNCTION. The sad part is I can only get these shots once every 6 weeks or so because insurance won’t pay for it and it’s hard on your liver I guess. But to have a combination of drugs that work so well on pain and is non-addictive...they should be used more for those whom are suffering."

9 / 10

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61 Report

Kandi...
Taken for less than 1 month
February 19, 2015

Norflex (orphenadrine) for Muscle Spasm "I was given this medicine for muscle spasms in the emergency room after 3 visits and 2 different hospitals. First I received an injection of Norflex and than a prescription for 2 a day for eight days. These pills worked wonders for the muscle spasms I had been having for about 3 months. I have been pain free for 4 months now."

9 / 10

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88 Report

Moray
February 19, 2017

Norflex (orphenadrine) for Muscle Spasm "I've been suffering from various back and nerve issues for almost a year now; 2 bulging discs and sciatica. Over the holidays I was unable to get in to see my primary care and ran out of my medications, resulting in a trip to the ER. The ER doc gave me an injection of Norflex and an rx until I was able to get in and see my doc. It has worked amazingly well. I've had minimal side effects taking it twice daily and within a half hour of taking it, my back spasms completely stop. It's been quite a relief."

9 / 10

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58 Report

love...
January 27, 2013

Norflex (orphenadrine) for Muscle Spasm "I found Norflex the only medicine that help to reduce my whiplash pain with minimal side effects. I only take one tablet in the morning on rising, it changed my life by reducing the severe pain of whiplash."

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79 Report

Kevin...
September 21, 2008

Norflex (orphenadrine) for Muscle Spasm "I find Norflex to be an amazing treatment for neck muscle spasms. I lead a pretty stressful life and every now (once every 3 months or so) and then suffer from muscle spasms in my neck and upper shoulder areas. This can be extremely painful. Sometimes by just taking 2 tables before I go to bed, will cure the problem. I have never needed to take more than 3 doses to relieve the spasm. There have been occasions that I did not have any Norflex and it will take quite a few days for the spasm to pass, even with regular massaging."

10 / 10

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100 Report

Shaji...
Taken for less than 1 month
February 11, 2015

Norflex (orphenadrine) for Muscle Spasm "I was perscribed 2 100 mg tablets twice a day for muscle spasms. This is the worst experience I have ever had. Only took 2 1 in morning and 1 in evening. I was up for 3 days straight jittery, agitated, mildly confused and spaced out. I had no pain but could not function a normal life on Norflex. I am 120 pounds."

4 / 10

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66 Report

Nurse
Taken for 2 to 5 years
November 8, 2012

Norflex (orphenadrine) for Muscle Spasm "I was given this while living in the Philippines as a combo med with Acetaminophen. It worked better than any pain medicine I had ever used without the side effects of stomach upset (Ibuprofen) or fatigue, sleepiness (codeine). "

9 / 10

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78 Report

Angie...
Taken for less than 1 month
May 12, 2020

Norflex (orphenadrine) for Muscle Spasm "Took it to ease the pain in my jaw from clenching my jaw and grinding my teeth in my sleep only took 1 tablet at night made me sleepy but definitely helped with the jaw pain until my mouth guard was ready"

9 / 10

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35 Report

Cuy
Taken for 6 months to 1 year
July 13, 2015

Norflex (orphenadrine) for Muscle Spasm "Very usefull for stress and muscle pain. But in the beginning a lot of side effects, due to the fact that I took 100 mg a day. (I only weight 45 kg). Now I"m taking 1/2 every day, sometimes every two days. I feel very good, and my husband is very happy, it saved my relation."

10 / 10

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63 Report

Chaddo
Taken for less than 1 month
February 4, 2018

Norflex (orphenadrine) for Muscle Spasm "took this medication for 3 days within 24 hours I could not read anything couldn't even read my watch. Pupils completely dilated like when I took powerful drugs in my 20s. This is some scary shit, the walls and floor in my toilet were also dripping like being on LSD, loss of balance as well. Now day 3 stopped, taking by 9pm 14hours later can sort of read again on my laptop and write this info. Does not agree with my"

5 / 10

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45 Report

Steff
January 9, 2021

Norflex (orphenadrine) for Muscle Spasm "I had a reversal ostomy yesterday. I'm currently in the hospital. I researched this medication. After it was given to me and it worked. Worked miracle for me. I can't take anything by mouth. This worked excellent"

10 / 10

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24 Report

Anonymous
February 26, 2023

Norflex (orphenadrine) for Muscle Spasm "Taking this medication was totally not for me. I have suffered anxiety all my life but it’s controlled on medication but when I was prescribed this my anxiety was next level. I’ve never felt so horrible in all my life. I was irritable, nauseous, fidgety, felt like constant panic, tense and didn’t help my condition at all. Obviously everyone is different but it’s not for me and will never take this again"

1 / 10

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10 Report

Sabear
Taken for less than 1 month
October 13, 2022

Norflex (orphenadrine) for Muscle Spasm "Norflex is amazing for Fibromyalgia and calming your whole body. It relaxes your muscles & you feel less tension & anxiety. Really helps the pain especially in my legs, hip & back due to Fibromyalgia. Game changer!!!"

10 / 10

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12 Report

DENISE
Taken for less than 1 month
May 1, 2023

Norflex (orphenadrine) for Muscle Spasm "Worst medication I’ve ever taken. Felt like I was out of it, difficult to function or think, like coming off drugs, and it didn’t make much of a change to the spasms. I took 100mg twice a day, but stopped after 4 days."

1 / 10

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8 Report

Rox
Taken for less than 1 month
August 16, 2021

Norflex (orphenadrine) for Muscle Spasm "A pharmacist gave me brufen tablets to take during the day and Norflex at night. I took one tablet of Norflex before bed, only to wake up in the middle of the night in pain again and it felt worse. I decided to take another tablet so that I could sleep again, but two hours later I woke up with the urge to go to the bathroom. I laid there paralyzed and it felt like my brain was swimming in my skull. I couldn't even speak to warn my partner about how I was feeling. Eventually I rolled on to my side grabbing the wall next to my bed to help me get up. It's been 11 hours since I took the last pill and I am still feeling the effects of it. The effects I experienced so far with it is, dry mouth, unbalanced, confused, difficulty with speech, very sleepy and being paralyzed."

1 / 10

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16 Report

Ozano
Taken for 6 months to 1 year
April 11, 2018

Norflex (orphenadrine) for Muscle Spasm "I have had lower back pain from degenerated disc since my 30's caused by a fall from a horse, then the same problem in my neck from a car accident. A few years ago I started getting what I put down to sciatica, then my right leg started collapsing on me and I have had several falls. I have strange effects to most medications they seem to affect me different to the norm, Norflex works perfectly on the pain side of things and generally reduces the falling. ( For migraines btw Relpax is amazing.) Norflex is now unavailable and I am desperate to know what to do I am back on Palexia but it has heaps of side effects and doesn't do the job."

10 / 10

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29 Report

BabyG...
Taken for 1 to 6 months
November 8, 2019

For Muscle Spasm "I'm normally prescribed Cyclobenzaprine (Flexeril), but asked my doctor to give me this Orphenadrine (Norflex) after they gave me a muscle injection of it in the ER , for a bad tension headache I had. I have upper back and neck spasms, had a second terrible tension headache for 2 weeks until I finally came to my senses and took this pill for a few days (I hate taking medicine), it really really helped relieve the headache. Also helps me sleep good, normally I wake up every few hours but when I take this I knock out for 6 hours straight."

10 / 10

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22 Report

FlatO...
March 5, 2012

For Muscle Spasm "In the last 10 years I have had 6 back surgeries. Several just Lamenectomies and 3 adding hardware and artificial disc replacement. I have many diagnosis including degenerative disc disease, narrowing of the spine, radiculapathy, failed back syndrome, etc, etc. I find when my muscles are relaxed I experience less pain since my spine isn't being contracted and less nerves are being pinched. This muscle relaxer worked GREAT had much less need for the narcotic pain medicines."

10 / 10

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45 Report

Lulu
Taken for 5 to 10 years
August 15, 2018

For Muscle Spasm "I have had severe muscle spasms in my mid and lower back for years. Was first prescribed methacarbomol but it wasn’t strong enough and gave me weird dreams. My doctor then prescribed orphenadrine and it does exactly what I need it to. Every time. It has never made me drowsy. I only take it when I need it such as when I’m driving all day or having to stand a lot. It has been wonderful!!"

10 / 10

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25 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.