Skip to main content

Doxycycline for Lyme Disease User Reviews (Page 3)

Brand names: Vibramycin, Monodox, Oracea, Doryx, Doxy 100, Adoxa, Acticlate, Mondoxyne NL, Doryx MPC, Targadox, LymePak, Uracil, Okebo, Doxy 200, Doxy-D, Oraxyl, Doxy-Caps, Alodox, Morgidox, Adoxa Pak, Avidoxy Adoxa TT Adoxa CK …show all brand names

Doxycycline has an average rating of 6.9 out of 10 from a total of 62 reviews for the treatment of Lyme Disease. 58% of reviewers reported a positive experience, while 21% reported a negative experience.

Reviews for Doxycycline

  • weina...
  • Taken for less than 1 month
  • October 6, 2015

Doxy 100 (doxycycline) "Having contracted Lyme's disease, I was given a 2 week regimen of Doxycycline, only a day before I travelled to Cyprus on vacation. Being told by my physician that I should be careful with sunning, I stayed inside during the day, coming out in the evening. However, the heat alone ?? made me within two days break out with large, but not painful blisters on hands, fingers and toes. Sandals was then used as I could not get into my shoes. Calling my doctor, I was told to stop the treatment immediately, which I did. I took me three weeks to get rid of the blisters, but obviously I cannot rate the effectiveness of the medicine as I cut the use of the pills within the first week."

1 / 10
Was this helpful?YesNo
21 Report
  • emsy
  • September 26, 2020

"Wanted to share my experience as I was really nervous to take doxycycline for Lyme disease due to the bad experiences mentioned all over the internet (and I have a fear of being sick). It was completely fine! I took 1 pill twice a day for 21 days, and always made sure to take them with food (avoid dairy as it affects absorption). It was completely fine! For a couple of days near the start there was some *slight* nausea, then nothing at all for about two weeks, then some nausea again at the end. I wasn’t sick, and I didn’t have headaches or any of the other symptoms mentioned here. Most importantly, they cleared up my horrible Lyme rash and hopefully mean that the illness won’t affect me in future. If you’ve been prescribed these for a similar reason DEFINITELY take them, plenty of people have few or no side affects and Lyme is something you do not want to mess with! Note: my dr also prescribed me pantoprazole to take once a day, to protect my stomach. I only did this for the first week"

8 / 10
Was this helpful?YesNo
11 Report
  • Madison
  • Taken for less than 1 month
  • July 17, 2018

"I’m 18 I found the tick on the top of my butt and I was getting ready to get dressed for graduation when I noticed it. My doctor prescribed me this as soon as she saw the mark it didn’t really look like a bullseye at all to me. 30 mins after I took it the next morning empty stomach like said I threw up for awhile I couldn’t eat a thing. Now I take it after I eat and I feel a lot better. I get headaches bad headache now and again and I also feel tired sometimes but I don’t have any bathroom issues."

8 / 10
Was this helpful?YesNo
15 Report

Frequently asked questions

  • Finn
  • Taken for less than 1 month
  • May 3, 2021

"I was prescribed a 3-week course. Within a couple of days I had feelings of dissociation, suicidal thoughts and felt my family has been replaced by other people. Personality change, impulsiveness, episodes of lots of energy, hearing voices. Mostly all resolved after stopping it."

1 / 10
Was this helpful?YesNo
9 Report
  • Anonymous
  • September 3, 2017

"I am a landscaper and had a deer tick latch on my upper thigh, just under my ass. One day later I noticed an irritable itching on that spot and didn't give it much thought thinking it was just a bad ant bite. For days later while laying in bed I decided to take a look too see what the hell was biting me down there and came to see I had deer tick latched on. I took the tick out killed it and saved it on some tape. Five days later after getting bitten my doctor didn't want to wait for a blood test and prescribed 100 mg of Doxycycline. To be honest with you I felt like my insides were slowly being eaten out with this drug. Highly recommend taking it with milk or 1 hour after eating food. I still currently feel EXTREMELY lethargic! It really sucks"

Was this helpful?YesNo
13 Report

Are you taking this medicine?

  • RILG
  • October 25, 2017

"I began to feel ill in mid June 2017. Muscle aches, mild fever, severe headaches, imbalance and just out of it. I could feel the veins in my head throbbing. It felt heavy. I saw my primary care who said I was coming down with something. Sent me for some blood work and referred me to a neurologist for the severe headaches. I saw the Neurologist end of July (earliest appointment due to a cancellation). I was sent for an MRI, normal. Sent to an ENT, normal. Sent to my eye Dr., normal. In October I finally had a West blot & other tests done and came up positive for Anaplasmosis. Began Doxycycline for 12 days. Headaches have seem to go away but still having some issues. Next visit is with the Lyme Specialist."

Was this helpful?YesNo
12 Report
  • Virgi...
  • Taken for 1 to 6 months
  • August 27, 2017

"Never saw the tick, but saw a quarter-sized rash with a distinct edge on my leg, so went to my doc immediately. Was put on a 2-wk course (100mg twice daily), Dr told me I could take it with food. Then had 2 wks off it (on vacation, and lab took forever to turn around my blood work). Tested positive for Lyme; Dr put me on 2nd 2-wk course. Since it's absorbed better on an empty stomach, started taking it that way. No ill effects, no nausea. However, blood tests still positive. Did a 3rd round; still have Lyme disease. Am now on my 4th 2-week round and am seeing a specialist in a few days. Worried that it's not working, but hopefully I just need a longer course. No side effects other than exhaustion."

8 / 10
Was this helpful?YesNo
12 Report

More FAQ

  • carda...
  • Taken for less than 1 month
  • May 8, 2017

"Spent 11 days in the hospital as a 10 year old kid with joint pain, rash, intermittent fever, high white blood cell count and a week later my hands and feet shed skin: 48 years ago, tested positive for lymes antibodies of both active and passive type and recieved 14 days of oxytetracycline therapy which appeared to cause severe fatigue but also cured left hand carpal tunnel syndrome (Doctor diagnosed) . Antibodies of only the passive type showed up 35 years after a precautionary test. Was bitten by an unknown critter who left a bulls eye ring 10 days a go and Doctor prescribed 14 days 100mg 2X day doxytetracycline. Hands and feet turned red today. I did have severe pain in my hip just today, perhaps exertion. Will see."

7 / 10
Was this helpful?YesNo
12 Report
  • Sophie
  • Taken for less than 1 month
  • August 2, 2022

"I’ve only taken this for a couple of days, and I’m so glad I read the reviews on here. Having severe depression since starting this. It is so scary to feel this way that I can’t risk taking another dose. Contacting my doctor to find a different treatment. Please be careful with this drug."

1 / 10
Was this helpful?YesNo
4 Report
  • Cjano
  • Taken for less than 1 month
  • April 27, 2020

"Avoid doxycycline like the plague! I was prescribed this drug as a precaution after being bitten by a tick which left an increasingly red ring surrounding the bite. After the first 3 doses my upper body and face were covered in an intensely itchy bright red rash. I was not out in the sun while taking this like many people who have a reaction to it. I have had a sun allergy since the 1990's and my body may have been a lot more sensitive to this drugs side effects. I started the drug on Thursday and only took one on Friday before calling my doctor. My prescription has been changed but I am suffering terribly from this still late Sunday night. Back to the doctor again tomorrow to see if I can put an end to this ungodly torturous rash."

1 / 10
Was this helpful?YesNo
7 Report
  • Carol...
  • Taken for 6 months to 1 year
  • September 19, 2021

"In 2017, I was first prescribed Doxycline 100mg, for an acute Lyme infection. I had a positive western blot.. I struggle with CRPS, Fibro, Spinal Stenosis, Scoliosis, Disc Herniations, Arthritis, and much more. It is very hard to decipher when I would have a Lyme flare but picked up on it this year. If I take 2 Doxycycline I feel a lot better, just once a day doesn't do much. I cannot take the IV med they offered me at the hospital as I'm allergic. Lyme is a life long sentence if you do not have an obvious tick bite. Please do you due diligence and esp. keep kids safe !"

7 / 10
Was this helpful?YesNo
5 Report
  • Anonymous
  • Taken for less than 1 month
  • October 19, 2017

"Third day taking this medicine. Extreme nausea to the point where I can't eat or drink without feeling like I’m gonna be sick/ actually throwing up. Really hope this works cause honestly don't know how I’m gonna stand three weeks of it."

3 / 10
Was this helpful?YesNo
9 Report
  • indig...
  • Taken for less than 1 month
  • October 31, 2016

"100mg x2 daily Was bit by a deer tick in MN on anniversary. My back was really itchy and my husband found I had a tick attached. I went to the doctor the next day with the tick to have it tested. Was put on this RX. First dose was very tired, but the rest is fine. No side effects. Fingers crossed negative on lyme."

10 / 10
Was this helpful?YesNo
10 Report
  • Lucy
  • Taken for less than 1 month
  • March 8, 2023

"It's probably helping the spot on my leg, but it's making me feel worse in every other aspect. Vague headaches, brain fog, an uptick in the volatility of past mental health issues, diarrhea, cramps, nausea, vomiting, I've got it all. This is making me so miserable I'd rather they just cut off my leg than make me keep taking this. 100mg twice a day for 10 days, it's been a week, when I feel good I feel great, but when I don't I'm in hell. I wake up gagging. Vile, foul, stuff."

1 / 10
Was this helpful?YesNo
2 Report
  • Tired...
  • Taken for 1 to 6 months
  • September 27, 2020

"I was on Doxy three times within 8 weeks. Each time I was prescribed 100mg 2x a day. The first time was 21 days for Lyme Disease and Shingles at the same time, things were ok, just a little dizzy. After being off it a week, the 2nd time was 7 days for a Cellulitis Infection, I felt queasy and dizzy with it that time. Third time was about a week later after a small hand surgery After 1 1/2 days I was so sick, I had nausea, dizziness, and vomiting. I threw the doxy away. I believe my body was done with taking so much of it in a close time frame."

5 / 10
Was this helpful?YesNo
2 Report
  • Anita
  • Taken for 6 months to 1 year
  • February 13, 2020

"Doxycycline saved my life. I don't understand why Canadian doctors are brainwashed into thinking Lyme disease is imaginary."

10 / 10
Was this helpful?YesNo
36 Report
  • Anonymous
  • Taken for less than 1 month
  • August 12, 2019

"I took doxycycline for Lyme disease for 4 weeks but I am still going numb in the legs"

1 / 10
Was this helpful?YesNo
23 Report
  • Stacine
  • Taken for less than 1 month
  • September 10, 2016

"I was diagnosed with Lyme, put on Doxy 200 mg a day, and my toes are numb and bright red as are my hands. Anyone else?"

Was this helpful?YesNo
24 Report
  • ztambor
  • December 19, 2017

"It doesn't kill Lyme. I had remissions, but never true wellness. 20 years a Lyme sufferer. As more research is now available, this should never be used for Lyme and co infections."

1 / 10
Was this helpful?YesNo
19 Report
  • Reywas
  • Taken for less than 1 month
  • April 9, 2022

"Caused suicidal depression. A rare side effect of this drug is psychiatric effects including suicidal thoughts and severe depression"

1 / 10
Was this helpful?YesNo
8 Report
  • Jane
  • Taken for less than 1 month
  • September 4, 2021

"Made me physically sick Took for Lyme and had to stop and take amoxicillin instead. Three years later I’m still suffering from this disease"

1 / 10
Was this helpful?YesNo
5 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Lyme Disease

Care guides

Symptoms and treatments