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Dihydroergotamine User Reviews & Ratings (Page 2)

Brand names: Migranal, Trudhesa, D.H.E. 45

Dihydroergotamine has an average rating of 7.1 out of 10 from a total of 45 reviews on Drugs.com. 66% of reviewers reported a positive experience, while 23% reported a negative experience.

Reviews for Dihydroergotamine

  • Molli...
  • February 1, 2009

Migranal (dihydroergotamine) for Migraine "My neurologist gave me a sample of this spray during my last office visit. We're going the non-Triptan route trying to manage my migraines since I previously had a reaction to Triptans. This spray did nothing for my latest migraine at all. In it's defense my migraines are pretty severe and even hard core narcotics aren't much of a match for them. The search continues."

1 / 10
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  • Anonymous
  • March 16, 2009

D.H.E. 45 (dihydroergotamine) for Migraine "I have had severe migraines for years. I finally was put on Topamax about a year ago but that wasn't enough, I still had attacks that kept me from doing anything about 2 times a months. None of the triptans worked so my doctor finally suggested DHE injections. She taught me to give them to myself so I can do them at home and now I can stop a migraine when it starts and not miss work for days on end. If anything I miss one day here and there."

9 / 10
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  • Joe...
  • December 9, 2017

Migranal (dihydroergotamine) for Migraine "Migranal works for me 100% of the time, although somewhat slow acting (1-3 hours). I used to get migraines about once a week, with duration of 1-3 days, sometimes severe. For the past 3 years, I have been taking 10 mg of amitriptyline at night, and 37.5/25 mg triamterene/HCTZ in the morning. Under this program, I get the beginning of a migraine about once every 1-3 months, and these events have been 100% controlled by Migranal. Btw, the addition of triamterene/HCTZ was for Meniere's syndrome, and the effect on migraine was a positive, unexpected side effect (amitriptylene alone had reduced the migraines to about 1-2 per month)."

10 / 10
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Frequently asked questions

  • Amelia
  • December 11, 2019

For Migraine "At 11 years old, I experienced severe and constant migraines that took me totally out of school and out of life. The drug Topiramate helped me cope for months, but then I was moved to the Neurology Hospital Dept where they first injected me with DHE (dihydroergotamine). Within seconds, I lost all vision and could not breathe at all- I thought for SURE- I am that was it. All Doctors sprinted into the room and one injected me with Benadryl and other anti inflammatories, which is what saved my life. This is not a drug to test unless you have tested all avenues. At 11 years old, my mom watched me slip into unconsciousness and further into oblivion, until my life was saved. Do NOT let this be you. I have worn a medical bracelet everyday since this occurrence. I have absolutely NO allergies to the outside world, but do not doubt that this drug can be your first and LAST experience with a bad allergy. PLEASE, be careful and especially WITH YOUR CHILDREN."

1 / 10
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  • PMM
  • July 31, 2009

Migranal (dihydroergotamine) for Migraine "I get very frequent migraines, up to 15 per month. Have tried just about everything, including narcotics to control migraines. I am currently on Inderall daily as preventative (have tried many, many, other drugs as well). Am currently taking Maxalt and Treximet, but doctor suggested we try the nasal spray. I had a full blown migraine when I tried it, so results may be a little off. Migranal caused burning in the nose, and throat, nasal congestion. It also left a nasty taste in my mouth. Woke up the next day with the migraine still lingering."

3 / 10
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Are you taking this medicine?

  • Manag...
  • December 19, 2015

For Migraine "I have used Migranal for years, but now the expense is very high. The medicine works well for me as well. The only reason for the cost is gouging by the drug companies that make this medicine. It is an old medication and the money they charge for it is not related to the cost of research or production. They charge this much because this country lets them get away with it. No other western country lets drug companies charge what they want for medicines. They should not be allowed to do it in the U.S. either. It is criminal."

9 / 10
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  • NatR
  • Taken for 2 to 5 years
  • May 25, 2022

D.H.E. 45 (dihydroergotamine) for Migraine "Side effects were nausea, vomiting, irritated skin site Hospitalized for 3 days for 6 IV treatment Pretreatment is Benadryl 50mg and Zofran 8mg Positive side effects was less migraines and side effects of migraines for 10 months"

10 / 10
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  • Laura
  • Taken for less than 1 month
  • February 12, 2022

Migranal (dihydroergotamine) for Migraine "My daughter gets migraines that last 1-2 weeks. After years of misery and nothing working, I finally convinced her neurologist to let us try this. I read all reviews so had her take a zofran first. I gave her one pump in each nostril, waited an hour and did one more on each side. Within 30 mins the migraine was gone! We were on day 7 of misery. I am so happy this works and can be used at home. She had received this once before after being admitted to the hospital for a 3 week status migraine. It was previously an infusion. I had no idea we could get this drug for at home use. This drug is very expensive to buy but I did find a coupon. For 8 doses I was willing to do it just to end our misery. If you haven’t had luck with triptans give this a try. It’s a miracle drug!!! The only side effect was a bad taste in her mouth. No nausea but I did have her take the zofran 20 mins before I used the spray."

10 / 10
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  • Anonymous
  • September 9, 2011

D.H.E. 45 (dihydroergotamine) for Migraine "I had several days of DHE IV's, a good try of migraines. A few weeks of injectable DHE and it didn't do a thing for me. I wish it worked for my constant headache. I heard a lot of good things about it."

1 / 10
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  • NJA
  • Taken for 2 to 5 years
  • November 7, 2022

For Cluster Headaches "It was a good abortive for my Cluster Headaches CH when I used at the beginning of the attack. I even used it to decrease my post exercise headaches but using a quarter of a pill. I stop using this drug because it cause numbness in my hands fingers meaning it was messing with my circulatory system…"

5 / 10
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  • New...
  • Taken for less than 1 month
  • May 26, 2023

For Migraine "After being refused permission to try medications from my pain treatment clinic, who only offered me super expensive and quite unpleasant/frightening surgical treatments and epidural steroid (and other serious types) injections, I found a way around them. I called my insurance and asked for medications that wouldn't require prior authorization from my pain clinic provider. Thankfully, I was successful and found an online appointment with a doctor who wrote me a prescription for this medication nasal spray. After 15 years of chronic and severe daily migraines (causing light, sound, fragrance, and ultra-sensitivity-induced vomiting) and countless painful procedures that didn't help whatsoever, this medication worked within 15 minutes. By 30 minutes, my migraine was completely gone. I am so very pleased that I don't have to worry any longer and can start living my life again without the fear of being crippled by debilitating and uncontrollable head throbbing and suffering."

10 / 10
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  • Aphra
  • Taken for less than 1 month
  • April 12, 2023

Trudhesa (dihydroergotamine) for Migraine "Used one time during a migraine episode (7 out of ten pain), the pain diminished in about 10 minutes to a 2-3 out of ten. The device/setup is a bit time-consuming but easy to use. However, side effects started immediately with dizziness, unwell physical and mental sensation. As well as severe burning in the nasal cavity/sinuses. I experienced nausea and abdominal pain (7 out of ten) for the next 2-3 hours. I took 25mg of Phenergan, yet I still projectile vomited 2 hours after the nausea began. I also experienced tingling in my arms and hands with mild to moderate discomfort. My sinuses became congested within the first hour and lasted the remainder of the night. I was unable to breathe through my nose until the following day. The next morning I awoke with mild nausea, diarrhea, fatigue, and a malaise feeling. Yes, the migraine dissipated and did not return the next day, but the side effects are too much for me to bare. I have had better experiences with other migraine medications, like Nurtec ODT."

5 / 10
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  • MillerM
  • Taken for less than 1 month
  • June 1, 2023

Trudhesa (dihydroergotamine) for Migraine "Within 4 hours of using Trudhesa I had chest pain and my watch alerted me of heart rate under 40 for greater than 10 minutes. I suffered bradycardia and pain, my heart rate has remained low and I’ve spent thousands in hospital bills and medical tests. And I still had a headache."

1 / 10
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  • Anonymous
  • Taken for less than 1 month
  • July 19, 2012

Migranal (dihydroergotamine) for Cluster Headaches "I have suffered from cluster headaches for 7 years. My doctors have tried it all on me then one day I was administered this. A God send after so many years of pain and emotional turmoil."

10 / 10
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  • Kensi
  • February 11, 2016

D.H.E. 45 (dihydroergotamine) for Cluster Headaches "Excellent. It worked to break the cycle without many side effects"

8 / 10
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  • Clust...
  • Taken for less than 1 month
  • August 10, 2014

D.H.E. 45 (dihydroergotamine) for Cluster Headaches "Rough side effect profile (nausea, leg cramping, and the injections burn). Have used every day for a couple weeks to shut down a bad cluster. Worked pretty good."

9 / 10
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  • Ronnie...
  • December 18, 2015

For Migraine "I have been on this for 16 years and it works great. The price has gone way up but at I get vouchers off internet I hope this helps someone."

10 / 10
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  • Linda...
  • October 26, 2016

For Migraine "The drug almost killed me. User BEWARE. Gave me pulmonary edema!!! The doctor never even came to see me when I returned to the hospital not breathing. Don't take it."

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  • Migra...
  • September 15, 2017

Migranal (dihydroergotamine) for Migraine "Took the nasal spray version. It doesn't seem to do anything. My migraines continued at the same frequency and intensity."

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  • Henry
  • Taken for less than 1 month
  • November 25, 2019

For Cluster Headaches "dihydroergotamine is the only medication that works for my headache. It works very good"

10 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.