Dihydroergotamine Pregnancy and Breastfeeding Warnings

Dihydroergotamine is also known as: D.H.E. 45, Migranal

Dihydroergotamine Pregnancy Warnings

Dihydroergotamine has been assigned to pregnancy category X by the FDA. Animal studies have revealed evidence of developmental toxicity including decreased fetal body weights and/or skeletal ossification, delayed skeletal ossification, and impaired reproductive function (decreased mating indices) in the offspring. There are no controlled data in human pregnancy. Dihydroergotamine is considered contraindicated for use during pregnancy.

DIhydroergotamine-induced intrauterine growth retardation has been attributed to reduced uteroplacental blood flow resulting from prolonged vasoconstriction of the uterine vessels and/or increased myometrial tone.

Dihydroergotamine Breastfeeding Warnings

There are no data on the excretion of dihydroergotamine into human milk. The American Academy of Pediatrics has no position on the use of dihydroergotamine during breast-feeding, but considers use of the closely related compound, ergotamine, to be contraindicated.

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