Dihydroergotamine Side Effects
Some side effects of dihydroergotamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to dihydroergotamine: nasal spray
Along with its needed effects, dihydroergotamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking dihydroergotamine:Less common or rare
- Chest pain
- cough, fever, sneezing, or sore throat
- feeling of heaviness in chest
- irregular heartbeat
- itching of the skin
- numbness and tingling of face, fingers, or toes
- pain in arms, legs, or lower back
- pain in back, chest or left arm
- pale bluish-colored or cold hands or feet
- shortness of breath or troubled breathing
- weak or absent pulses in legs
- convulsions (seizures)
- nausea and/or vomiting
- numbness, tingling, and/or pain in the legs or arms
- shortness of breath
- stomach pain
Some side effects of dihydroergotamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Burning or tingling sensation, dryness, soreness, or pain in the nose
- change in sense of taste
- dry mouth
- increased sweating
- nausea and or vomiting
- muscle stiffness
- runny and or stuffy nose
- sudden sweatings and feelings of warmth
- sensation of burning, warmth, or heat
- sore throat
- unexplained nose bleeds
- unusual tiredness or weakness
- blurred vision
- cold clammy skin
- congestion in chest
- decreased appetite
- difficulty swallowing
- dizziness or lightheadedness when getting up from a lying or sitting position
- ear pain
- eye pain
- increased watering of eyes
- increased watering of the mouth
- increased yawning
- muscle weakness
- pinpoint red spots on skin
- pounding heartbeat
- red or irritated eyes
- ringing or buzzing in ears
- skin rash
- stomach pain
- sudden fainting
- swelling of face, fingers, feet, or lower legs
- trembling or shaking of hands or feet
- trouble in sleeping
- unusual feeling of well being
For Healthcare Professionals
Applies to dihydroergotamine: injectable solution, nasal spray
Gastrointestinal side effects including nausea, vomiting, and diarrhea have been reported to occur commonly.
The most frequent side effect with the use of intravenous dihydroergotamine is nausea. Following intramuscular or intranasal administration, the incidence of nausea is low.
Other side effects including arterial spasm, sometimes with resulting limb necrosis, have been reported rarely. The incidence is believed to be about 1 to 3 per 100,000 patients treated for thromboprophylaxis.
Musculoskeletal side effects including muscle cramps and weakness have been reported.
Nervous system side effects including drowsiness, restlessness, cerebral arteriopathy, and paresthesias have been reported.
Local side effects including pain, burning, itching, edemas, and hematomas at the site of parenteral administration have been reported to occur commonly.
Cardiovascular side effects including hypertension, tachycardia, bradycardia, precordial distress, and chest pain have been reported. Myocardial ischemia and myocardial infarction have been reported rarely.
Respiratory side effects including pleural fibrosis have been reported following long-term high dose treatment.
Renal side effect including retroperitoneal fibrosis have been reported following long-term high dose treatment.
More dihydroergotamine resources
- dihydroergotamine Nasal Advanced Consumer (Micromedex) - Includes Dosage Information
- dihydroergotamine injection Concise Consumer Information (Cerner Multum)
- dihydroergotamine MedFacts Consumer Leaflet (Wolters Kluwer)
- D.H.E. 45 Prescribing Information (FDA)
- Dihydroergotamine Mesylate Monograph (AHFS DI)
- Migranal Prescribing Information (FDA)
- Migranal spray MedFacts Consumer Leaflet (Wolters Kluwer)
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