Skip to main content

Amitriptyline for Fibromyalgia User Reviews (Page 4)

Amitriptyline has an average rating of 6.5 out of 10 from a total of 103 reviews for the off-label treatment of Fibromyalgia. 46% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Amitriptyline

  • Anonymous
  • December 19, 2009

"I have had success with it helping me stay asleep through the night, but it has not helped with my muscle/joint pain and daytime fatigue. I have also gained about 15 pounds over the course of four months despite a decrease in my appetite."

3 / 10
Was this helpful?YesNo
18 Report
  • KEDCC
  • Taken for less than 1 month
  • November 14, 2016

"I've only been on the medication for 4 nights and I've noticed that my stool has changed color. Would this be one of the effects perhaps or totally not related???? So far in this early stage, I have not noticed any difference with my fibromyalgia."

1 / 10
Was this helpful?YesNo
11 Report
  • Anonymous
  • November 5, 2009

"I have fibromyalgia, SLE, migraines and nerve pain and was started on Amitriptyline 10mg in January of 2008, was increased to 20mg that fall, and have been increased to 30 mg for the last 4 months. I found it helpful, it decreased all my symptoms, but increases were needed as the effectiveness wore off in time. My physician informed me that he would not increase the dosage past 30 mg as anything over 30mg was only effective in treating the antidepressant symptoms, not nerve related symptoms. He added Gabapentin 1 month ago, but I felt no change. He would now like me to stop both of these meds, and try Lyrica. I would like to add that I too have gained 50 lbs, and crave sweets always."

7 / 10
Was this helpful?YesNo
17 Report

Frequently asked questions

  • nelso...
  • August 1, 2009

"I developed fibromyalgia recently. I had been on low dose of a similar medication (Doxepin) for long time, mainly for a sleep disorder. The neurologist I saw for my fibromyalgia suggested switching from Doxepin to Amitriptyline. Overall, I am glad I made the switch, as my fibromyalgia is now much more manageable. I take 35 mg of amitriptyline nightly. Initially very sedating, but now less so. It has also helped my irritable bowel syndrome. On the negative side, it has led to constipation problems, and my irritable bladder (bladder urgency) is now much more chronic, which is surprising because amitriptyline has higher anticholinergic properties. But my pharmacist feels that Doxepin must have helped me more with that. NOTE: Beware of combining amitriptyline with Detrol LA (for bladder urgency)."

8 / 10
Was this helpful?YesNo
16 Report
  • njm
  • May 8, 2016

"well, i have fibromyalgia. my doc gave me gabapentin or something like that, which made my pain lower, but then again, i was asleep, because it made me sooo sleepy, and angry, very very very angry, and crying spells, ugh!, I did not want any more pills, but my doc gave me amitriptyline hcl 10, but after reading the reviews i am honestly afraid to drink it... i feel lost...but i was told to go Paleo diet, which i researched and heard good things about. I may go Paleo and pill, and see what helps me more."

Was this helpful?YesNo
10 Report

Are you taking this medicine?

  • geese...
  • Taken for 1 to 6 months
  • February 9, 2023

"I was diagnosed with fibromyalgia a few months ago and was immediately put on this medication for fibromyalgia and for my existing IBS, and depression. It works for all three, but it doesn't cure anything completely. It doesn't take long for it to work however if I miss a dose or two, my symptoms come back pretty quickly. My pain dulls to almost nothing, and what I'm left with is an uncomfortable feeling sometimes instead of pain. I've had trouble sleeping my whole life, and I will say that I do sleep very well after being on this medication for about 3 months now. Amitriptyline makes me feel more human again."

7 / 10
Was this helpful?YesNo
2 Report
  • Fibro...
  • Taken for 10 years or more
  • April 11, 2021

"I have used Endep for many years now for sleep and fibromyalgia. Fibromyalgia has many strange symptoms. At one stage I found that taking my Endep gave me very painful and unpleasant restless legs. I managed this for a while by taking pain relief before taking amitriptyline. Luckily this symptom/side effect passed after a few months. Fibromyalgia symptoms are constantly changing. Sometimes within hours or sometimes years. I had painful sinus headaches for over 4 years every morning. The amitriptyline does have anticholinergic side effects like slowing the digestive system and causing a dry mouth. Which has been a significant problem. But this has just as much caused by fibromyalgia and the side effects can be managed. The amitriptyline has a slow effect on pain. If I stop it for a week my pain levels will slowly increase. And I get some twitches when I do not take it but is not a problem."

7 / 10
Was this helpful?YesNo
3 Report
  • Jaltoni
  • Taken for less than 1 month
  • August 27, 2017

"Well I haven't started this med yet. But I am going to be taking this for my fibromyalgia. I'm already taking gabapentin for my joint and muscle pains. It seems to help But, anyways will find out soon."

Was this helpful?YesNo
3 Report
  • Green
  • Taken for less than 1 month
  • November 3, 2022

"Only had 10mg a night for a week. The side effects were so severe had to stop. So detached and drowsy, couldn't function, didn't know what I was saying, intrusive/obsessive thoughts. Thought I was having a nervous breakdown. 2 week on still have severe anxiety, panic attacks, constant adrenaline rushes, can't sleep, if I do for a short time I get vivid nightmares. Constantly wake up in a cold sweat. Couldn't eat a thing for 8 days. Feel detached. Can't work. It's ruined my life. Now on propranolol and diazepam. Was on no medication before this. Worst thing I've ever taken."

1 / 10
Was this helpful?YesNo
1 Report
  • DLyons
  • May 16, 2021

"I’ve been in pain which first started in Sep2020 was very fit active before that had suffered from depression in the year before but got out of that! Then I went to an osteopath in Oct got told that I may have fibromyalgia and hyper mobile syndrome and was told I was in a flare up! Was taking paracetamol, ibruphen, Naproxin so on whilst waiting for a rheumatology appointment but wasn’t until April 21. I've been in so much pain mainly in shoulder blades right shoulder feels like comes out socket have no appetite and now problems with liver Had the appointment got told I have fibromyalgia, like I expected ,and been on 30mg amitript taking at 8.30pm every night but haven’t noticed any difference - if anything I feel worse. I have pains in ears, throat at the same time I’ve been taking the co drydamol everyday and ibuprofen and just feel worse and worse. I just want it to go away and now I’m on antibiotics because of this causing sinuses ear infection which just want it to go! 5 weeks on it, shall I stop taking other PKs to let this work?"

4 / 10
Was this helpful?YesNo
1 Report
  • fibro
  • Taken for less than 1 month
  • August 22, 2023

"Rheumatologist prescribed this for fibromyalgic pain. I had a great sleep on a quarter of a tablet. It did help with pain, but then I became tired as I did a little too much. And I did trip out a little, even on such a small dose. I then took it for sleep a couple more times over the next week, then I stopped as it must've lost effectiveness. Many years later, the doctor is now prescribing it for sleep, and I'm not sure I will again, as it was so strong."

7 / 10
Was this helpful?YesNo
0 Report
  • Anonymous
  • December 17, 2011

Endep (amitriptyline) "Endep had a very quick effect and eliminated the muscular pain that I have suffered for more than ten years. I do feel drowsy, its seems to have a calming effect on me and I sleep amazingly well."

10 / 10
Was this helpful?YesNo
131 Report
  • Anonymous
  • Taken for 1 to 2 years
  • October 19, 2016

Endep (amitriptyline) "Wonderful for my fibromyalgia. It helps reduce pain and helps me get a solid nights sleep. I take 50mg 2 hours before bedtime. Recommend this highly."

10 / 10
Was this helpful?YesNo
71 Report
  • Zaney...
  • Taken for 6 months to 1 year
  • September 30, 2013

Elavil (amitriptyline) "I was diagnosed 14 yrs ago with Fibromyalgia. My doctor prescribed Elavil.10 mg. per day. It helped me sleep better but heart began beating to fast and was discontinued. Helped a little with pain."

5 / 10
Was this helpful?YesNo
65 Report
  • SJS
  • January 22, 2018

"I've been taking Amitriptyline for 16 years with no side effects. I take 50 mgs in the evening and have had virtually no pain with only very few flare ups."

10 / 10
Was this helpful?YesNo
36 Report
  • Anonymous
  • April 18, 2011

Elavil (amitriptyline) "Helps well with my anxiety as well!"

10 / 10
Was this helpful?YesNo
58 Report
  • Megcait
  • Taken for 5 to 10 years
  • August 24, 2014

Elavil (amitriptyline) "Take at night, and once I fall asleep, it helps. Doesn't stop the pain/discomfort of trying to get comfortable to fall asleep."

7 / 10
Was this helpful?YesNo
46 Report
  • Mel
  • Taken for 1 to 6 months
  • January 26, 2016

"I find amatriptilene 50mg is helping me get a more refreshed sleep for my fibromyalgia and thus helping with pain issues....had fibro 30 plus years so its the best one I've had"

10 / 10
Was this helpful?YesNo
39 Report
  • Shushi
  • Taken for less than 1 month
  • November 17, 2019

"Im taking this amitriptyline for 4 weeks for FM and I feel relieved for the first night, I'm free from fibromyalgia pain.I can work without pain, and fatigue"

10 / 10
Was this helpful?YesNo
24 Report
  • Minders
  • January 9, 2013

Elavil (amitriptyline) "Helped me fall asleep, but I didn't stay asleep so it had no real impact in helping my pain."

3 / 10
Was this helpful?YesNo
47 Report
  • Chris...
  • Taken for less than 1 month
  • July 31, 2018

Endep (amitriptyline) "Have been on this for 2 days now, first and second night, best sleep ever...wait & see !!!"

10 / 10
Was this helpful?YesNo
28 Report
  • mikeal
  • May 1, 2009

Elavil (amitriptyline) "I have just started to use Elavil - this is my third day of taking this medication and I already feel a little better."

5 / 10
Was this helpful?YesNo
57 Report
  • lsals...
  • June 9, 2014

"I take Amitriptyline for nerve damage resulting from my stroke. I started to itch in the evenings as a result of the nerve damage. This really helps and I sleep well with this medicine too."

10 / 10
Was this helpful?YesNo
39 Report
  • Anonymous
  • June 19, 2009

Elavil (amitriptyline) "I have been on 100mg for 1 year now. Works great for sleep and pain. Downfall, I have gained 50lbs."

7 / 10
Was this helpful?YesNo
50 Report
  • Anonymous
  • May 25, 2009

Elavil (amitriptyline) "Started with 25mg in 1987, increased to 100mg recently. Overall not that much different than the others, gained a lot of weight as with Neurontin, but it did help sleep and mood issues."

6 / 10
Was this helpful?YesNo
45 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Fibromyalgia

Care guides

Symptoms and treatments

Medicine.com guides (external)