Amitriptyline Pregnancy and Breastfeeding Warnings

Amitriptyline is also known as: Elavil, Endep, Vanatrip

Amitriptyline Pregnancy Warnings

Amitriptyline has been assigned to pregnancy category C by the FDA. In animals, amitriptyline produces a variety of congenital malformations when administered in doses 8 to 33 times the maximum recommended human dose. Several cases of congenital malformations, including limb reduction defects, in infants whose mothers took tricyclic antidepressants during pregnancy have been reported, although no firm association has been established. Neonatal withdrawal symptoms have also been reported. There are no controlled data in human pregnancy. Amitriptyline is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

Amitriptyline Breastfeeding Warnings

Amitriptyline and its active metabolite nortriptyline are excreted in small amounts into human milk. Infant serum analysis failed to find detectable concentrations. The American Academy of Pediatrics classifies amitriptyline as a drug "whose effect on nursing infants is unknown but may be of concern".

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