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Amitriptyline Pregnancy and Breastfeeding Warnings

Amitriptyline is also known as: Elavil, Endep, Vanatrip

Amitriptyline Pregnancy Warnings

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. AU TGA pregnancy category: C US FDA pregnancy category: C Comments: -Withdrawal symptoms have been reported in neonates whose mothers had taken tricyclic antidepressants during the last trimester of pregnancy. -Cardiac problems, irritability, respiratory distress, muscle spasms, seizures, and urinary retention have been reported in infants whose mothers received tricyclic antidepressants immediately prior to delivery. -Limb deformities and developmental delay have been reported in infants whose mothers had taken this drug during pregnancy.

Animal studies have shown harmful effects at exceptionally high doses. There are no adequate and well-controlled studies in pregnant women. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Amitriptyline Breastfeeding Warnings

AU, US: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. UK: Use is contraindicated. Excreted into human milk: Yes Comments: The effects in the nursing infant are unknown.

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