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Acetaminophen / hydrocodone for Rheumatoid Arthritis User Reviews (Page 2)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 4.5 out of 10 from a total of 77 reviews for the off-label treatment of Rheumatoid Arthritis. 34% of reviewers reported a positive experience, while 57% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

  • Dano
  • March 17, 2021

Norco (acetaminophen / hydrocodone) "Feb 28,2021 I've been getting my prescription Norco 10/325 from CVS and lately they haven't been working on my pain. So I called my doctor and mention it they suggested I try a different pharmacy could be manufacturer so I did. I tried Walgreens worse decision because they gave me a brand called Mallinckrodt. It don't help at all with pain. I've had really horrible side effects bad weigh gain, head aches, depression, forgetfulness. Never again."

1 / 10
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30 Report
  • Rstarre
  • Taken for 1 to 2 years
  • May 27, 2022

"I have been taking hydrocodone for eight years for spinal degeneration and bone spurs. Walgreens use to have Watson brand hydrocodone. Then they switched to mallinckrodt. There version of hydrocodone is terrible. They are not nearly as effective at stopping my pain, they also put me in a terrible depressed mood. They also upset my stomach and even causing stomach pain. I had none of those issue in all the years of taking the Watson brand. Is mallinckrodt making hydrocodone weaker and what kind of fillers are they using that cause stomach problems"

3 / 10
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20 Report
  • Rasheia...
  • Taken for 1 to 2 years
  • October 26, 2021

"I have been an R.N. for the past 25 yrs. I have severe pain in my back, arms, knees and legs from R.A.. Most days I'm crying in severe pain and this terrible hydrocodone does nothing for my pain! It is inhumane to allow this kind I was prescribed oxy 30 mg & they always helped my pain and was able to work full time. I never took more than 2 to 3 a day. Pain management dr cut my prescription of oxycodone down and prescribed 4 to 6 of the 10 mg hydro/day. I have been in agony for the past year because of this med not helping me! Now I have severe ringing in my ears that never goes away! I thought maybe I had a tumor & had 3 MRI's to check my ears, my head and my arteries. Mind you I had to pay a 2K deductible. After reading all these other reviews I see I'm not alone. The FDA is obviously in on this charade or they don't just don't care. There's going to be a huge lawsuit against the FDA when this is uncovered! It IS inhumane 2 let people suffer like this, this is a crime."

1 / 10
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24 Report
  • Angel
  • Taken for 1 to 6 months
  • November 11, 2019

"Using hydrocodone / acetaminophen 10/325 & it's not working. Last prescription not working, suggested my pain has increased. I purchased next prescription, no relief. Took two 10/325, no relief, & didn't make me sleepy. I believe it's the medication. I waited for the time for my next dose & instead took 800 mg of Motrin & a BC powder & got some relief. Waited for next time if medication dose, took 2 hydrocodone again, nothing. I was crying & in much pain. I've never taken pain meds my entire life until I was diagnosed with RA & SLE. This medication should be working for me but it isn't. I was admitted to the hospital for stomach issues & was given a hydrocodone 10/325 in the hospital, it knocked me out! I asked them to request an order from doctor to only take half of the hydrocodone while I in the hospital & the half hydrocodone in the hospital relieved my pain. I've read comments from internet, other people having same issues."

1 / 10
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37 Report
  • crunc...
  • Taken for 5 to 10 years
  • September 18, 2018

"The hydrocodone made by Mallinckrodt Pharmaceuticals is a much weaker version of the one made by Watson. Be aware when taking this medication that many generics do not assist with pain the same way as other brands. I have found the main difference is pain relief. Where as I take one Watson made hydrocodone it equals the effectiveness of 1 1/2 Mallinckrodt Pharmaceuticals made hydrocodone (M366). I know from research companies make medications with different ingredients etc, and I would recommend to anyone that if you are taking this medication (hydrocodone) you splurge a little on your wallet and ask for the Watson made brand. It is more effective, lasts longer, and doesn't give you headaches. Please also never take this med to get "high" it causes regulations that make us true pain sufferers suffer more to curb your addictions and criminal behaviour. Ty."

5 / 10
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42 Report

Are you taking this medicine?

  • Captain...
  • Taken for 5 to 10 years
  • January 17, 2020

Norco (acetaminophen / hydrocodone) "What’s everyone’s issue with Mallinkcrodt? I’ve been taking 10-325 for 5 years. When I don’t take them, I’m in tremendous pain. When I do take them, I am not. They work just fine for me... Take them as prescribed and with ibuprofen if necessary."

10 / 10
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31 Report
  • Mikey
  • Taken for 10 years or more
  • February 2, 2021

"I have suffered with the pain of chronic RA for the last ten years. This past month the Walmart pharmacy switched my hydrocodone to the brand Camber. They offer zero pain relief. Honestly I took a baby aspirin they gave me more pain relief that the 10 mg acetaminophen/hydrocodone camber brand. Maybe if these pharmacies pharmacists suffered from RA they would start demanding the manufacturers of these junk generic brands be tested because they cannot have any opioid pain medication in them. Suffering in the mountains."

1 / 10
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25 Report
  • Peggy
  • Taken for 5 to 10 years
  • February 24, 2022

Norco (acetaminophen / hydrocodone) "I have crippling arthritis, degenerative disk disease and about to have cervical spine surgery with putting in a metal plate Bolts and fusion. I’m also scheduled for knee replacement as soon as possible after cervical surgery. Since they’ve taken the Yellow Norco off the market I’m getting no relief!! With some of the white norco I get maybe a bit of relief but with others no relief at all!! I believe some may have a small amount of hydrocodone but others none!! Surely something could be done. If the ones responsible for this had the pain most of us have I guarantee they’d be doing something about it!!! PLEASE bring the Yellow Norco back!!"

1 / 10
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18 Report
  • riderz
  • Taken for 2 to 5 years
  • April 6, 2022

"I guess I have been one of the lucky ones, until I filled my prescription last month. I have been prescribed a 10/325 Norco for RA. The Watson brand(yellow football) was keeping me self employed for the past 5 years. I am in so much pain with this new Mallinckrodt or however it is spelled, a lot of times I elect for just Tylenol. I am allergic to any anti-inflammatory like Ibuprofen. I rely on Acetaminophen at night any way as I cannot sleep with Norco. I am on board with getting some kind of action to get our good medications back. I called several Pharmacists and they tell me whatever is cheapest is what they get. This whole madness of cracking down on opiates is driving so many to street drugs and leading to deaths and overdoses."

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17 Report
  • Tina
  • November 13, 2019

"The Tris brand of acetaminophen and hydrocodone with imprint G037 doesn’t help with my pain and it’s thrown me into a horrible depression. This is horrible I’ve been seriously depressed since I’ve been on this medication for over a month and I’m still in pain. This medicine is horrible. Good luck out there."

1 / 10
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30 Report
  • Blood...
  • Taken for 2 to 5 years
  • January 29, 2018

"Just been in so much pain since CVS went to Lupin hydrocodone, I noticed the first day and first dose something was wrong , it doesn't work, unfortunately CVS says this is it. My insurance won't cover any thing else , went to my doctors , he increased the amount , however even this does nothing , I've been told it's me , that no one else has complained , I find this hard to believe ,"

1 / 10
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37 Report
  • Catpan
  • July 29, 2013

"I have been taking Vicodin 5/500 for the past four years for rheumatoid arthritis and Osteoporosis. I tried Norco 5/325 when I had my knee replacement and it made me drowsy with a brain fog and nauseated. I asked my surgeon to give me Vicodin and he insisted that it was all the same. I continued to try the Norco and just did not like it so I called my primary care physician and she put me back on the Vicodin. What a relief. Vicodin really helps my pain. "

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55 Report
  • bornin
  • Taken for 2 to 5 years
  • August 15, 2018

"I thought it was me. I have arthritis in my neck and have been on 7.5-325 for a while. My pharmacy is CVS and for the last year ( at least ) I've been getting the white pills from Lupin, they're awful compared to the other generics I've taken. I believe I'm switching pharmacies next month after reading the comments on here. Thank you all for sharing, now I know I'm not any crazier than I've always been!"

3 / 10
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34 Report
  • Fedup
  • Taken for 10 years or more
  • October 17, 2021

Norco (acetaminophen / hydrocodone) "Ever since Watson brand became unavailable I've had not much luck with the brands available. I tried several pharmacies with little to no luck. I've been taking first hydrocodone since mid 1990s and about 5 years ago began Norco 10/325 My doctor never had a problem prescribing my meds and had me sign a waiver to continue use. I've been to two different pain clinics over the years and they did no good. I moved to Washington and my new Dr won't provide any pain meds except muscle relaxers which never worked. Now I am forced to buy my meds through the street from my Dr's own patients. So very wrong. What is wrong with this world!!"

8 / 10
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18 Report
  • Reese
  • January 19, 2020

"To all of you that are having bad experiences with Tris Pharma hydrocodone with acetaminophen I suggest letting the pharmacy know I suggest complaining to your pharmacist corporate office I suggest calling the FDA and filing a complaint other than just posting here because if not enough people see anything nothing will be done I have rheumatoid arthritis mostly in my hands but in all of my joints and have a hard time getting out of bed in the morning I also have degenerative disc disorder in my lower back . Walgreens pharmacy has Tris and they will not order another brand per my doctor’s electronic prescription. I was told “what we have on our shelf is what you get “ Tris brand of hydrocodone with acetaminophenmakes me very itchy it either makes me really tired or very hyper and it does nothing to relieve my pain two hours later I will be asking myself if I even took a pain med."

2 / 10
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26 Report
  • Any...
  • January 25, 2017

"I have been taking the Watson brand for over ten years and it helped me tremendously with my RA pain. Now I am having to resort to this pill bc NO PHARMACY will order the Watson brand! Why is this? Does any one know bc this pill does not touch the pain like the Watson brand. I hope I am not the only one that thinks this pill doesn't work as well... Is it the chemical make-up bc I was told generic is just the same... To me it's not! One pharmacy does carry the Watson brand but does not take my insurance so I have to pay full price! In my opinion this is why we have these pills being sold on the streets bc people who actually needs them cannot get them in pharmacies! Any one have an opinion on this?"

3 / 10
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37 Report
  • THano
  • Taken for less than 1 month
  • September 3, 2020

"I have been on acetaminophen with hydrocodone for 6 years and just in the last 2 weeks I got a refill with Amneal brand pills, I thought it was the end of me. Had to switch to 1/2s and then was spacing them 9 hours apart but would become loopy, headache and no pain relief but a high which was NOT enjoyable, and a heart rate that wouldn't slow. Has anyone felt like this on the Amneal brand of acetaminophen with hydrocodone?"

1 / 10
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22 Report
  • Big...
  • Taken for 2 to 5 years
  • September 15, 2018

"I've tried them all, but I was very fond of the Watson imprint it worked well. Now it is my understanding they don't use them anymore. I'm really annoyed now. They give us these low cost cheap generics brands that I personally think don't even have all 10mg of the active ingredient in them. I've had it up to here with the pharmacies and there practices ..stop trying to make money off of us folks in pain."

4 / 10
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30 Report
  • Chris
  • November 28, 2018

"Since all the pharmacies in my area have switched to Tris brand, everyone I know have gotten sick from them. Everybody complains and pharmacies don't care, Drs and Pharmacist treat all patients bad like they are addicts, even legitimately ill patients. They are truly playing god . FYI, i did my research and found out watson was sued by the state of Mississippi and so sold out to activis and are no longer making watsons."

1 / 10
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29 Report
  • Wny
  • May 24, 2015

"In the past four yours , my disease has progressed . I have been able to control my pain with hydrocodone. Recently started getting Watson 853 . The pain has returned , now stomach upset and headache . Plus tired all the time . I take 2 10 mg 325 . Now I feel I have to take more . I have read on other sites that Watson was bought by another company . What did they do ? Please let us consumers and chronic pain patients the respect we deserve , and tell the truth . We're not crazy , you changed the active binding ingredients . Was this to save money ? Well I'd rather stop purchasing this placebo and deal with my pain. I just hope that no one dies by taking to much . Because I've read how patients are over medicating to get relieve ."

2 / 10
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42 Report
  • Savan...
  • Taken for 2 to 5 years
  • October 27, 2018

"Had used Qualitest Brand for years (pink with V and very hard tablet) and would have rated pain relief a 7. CVS will not carry Qualitest anymore and gave me Lupin. I get virtually no relief and they aggravate my ulcer to the point I have to take Carafate. I take them as ordered. At my last doctors appointment, they did a urine screen. NO hydrocodone was found in my urine. I had taken one the night before at 8pm and one at 8am. The test was at 1pm. The pharmacy has now given me a different brand. Qualitest was recalled for having too much acetomenophin. Myland is now distributing the Qualitest brand. The pharmacist is ordering those to see if it helps. It is absurd there is such a variance in quality and strength. We will see how this goes!"

3 / 10
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29 Report
  • Anonymous
  • February 14, 2011

Lortab (acetaminophen / hydrocodone) "Dealing with chronic pain is never easy. I've tried Mobic but it led to stomach bleeding. I've tried vicoprofen but it made me swell and ache even more. Have used Vicodin but of course tolerance resulted. I now find that Lortab and Lorcet work great. I only need to take 2 a day for real relief. The only other combination I used that worked was Vioxx once a day and Vicodin 2x a day. Wish they hadn't taken Vioxx off the market."

10 / 10
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54 Report
  • Rhaps...
  • Taken for 1 to 2 years
  • March 22, 2022

"I was started on hydrocodone with acetaminophen one 325 from Watson Labs. During flares when aspirin or Alene, Motrin or Advil can’t help ease my flare pain, I’d take my Watson hydrocodone. It would ease me enough I could finally fall asleep and no nausea It helps me during the more than usual painful days. Watson Labs hydrocodone worked great for me. Over a year ago, my pharmacy changed brands and I’ve not had a painless time since…only nausea and no relief! Why? Can we request or demand the brand that actually helps?"

8 / 10
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13 Report
  • Mort...
  • Taken for 2 to 5 years
  • February 9, 2019

"I have charted every acetaminophen/hydrocodone I have taken for the last five years. The relief has always been consistent until the last year when results seemed to vary. I never gave the supplier any notice because the results were consistent and spectacular for my pain relief. I thought I may have been imagining more recent poor results and after reading other patient reactions in these comments I now suspect my current supplier of quality control issues. I have been using medication made by Aurobindo ( UO3 ). My current pharmacy could not supply another brand so I went to another and got a medication made by Lupin Limited ( n 358 10 ). Just started today but I can't find and comments about this company either good or bad. Hoping it works better than what I have been using. Would like to hear any other feedback."

4 / 10
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22 Report
  • Anonymous
  • Taken for less than 1 month
  • February 13, 2014

"This medicine was taken primarily for shoulder pain. It helped very little as there was always a little pain in the shoulder when I took them. The pain never actually went away. The pill only lessened the pain but did not eliminate it."

5 / 10
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31 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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