Acetaminophen / Hydrocodone Dosage

This dosage information may not include all the information needed to use Acetaminophen / Hydrocodone safely and effectively. See additional information for Acetaminophen / Hydrocodone.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Pain

Initial dose:
1 tablet (acetaminophen/hydrocodone 500 mg-5 mg) orally every 6 hours as needed or
10 mL (acetaminophen/hydrocodone 333 mg-5 mg) oral elixir every 6 hours as needed or
15 mL (acetaminophen/hydrocodone 325 mg-10 mg) oral solution every 4 to 6 hours as needed or
15 mL (acetaminophen/hydrocodone 500 mg-10 mg) oral elixir every 4 to 6 hours as needed.
11.25 mL (acetaminophen/hydrocodone 300 mg-10 mg) oral elixir every 4 to 6 hours as needed.

Many different combination dosage forms of acetaminophen-hydrocodone are commercially available. In general, combinations with 5 mg of hydrocodone are given 1 to 2 doses every 4 to 6 hours, up to 8 doses per day. Combinations containing 7.5 or 10 mg of hydrocodone are given once every 4 to 6 hours, up to 5 or 6 doses per day (depending on how much acetaminophen they contain).

Usual Geriatric Dose for Pain

Initial dose: 1 tablet (acetaminophen/hydrocodone 500 mg-2.5 mg) orally every 6 hours as needed or 5 mL (acetaminophen/hydrocodone 167 mg-2.5 mg) oral elixir every 6 hours as needed.

Usual Pediatric Dose for Cough

Antitussive (doses based on hydrocodone):
Children: 0.6 mg/kg/day or 20 mg/m2/day divided in 3 to 4 doses/day
Less than 2 years: Do not exceed 1.25 mg/single dose
2 to 12 years: Do not exceed 5 mg/single dose
Greater than 12 years: Do not exceed 10 mg/single dose

Analgesic: Children: Dose has not been well established:
Opioid-naive patients (dose based on hydrocodone):
Children and Adults less than 50 kg: Usual initial dose: 0.1 to 0.2 mg/kg every 3 to 4 hours
Children and Adults greater than or equal to 50 kg: Usual initial dose: 5 to 10 mg every 3 to 4 hours

Usual Pediatric Dose for Pain

Antitussive (doses based on hydrocodone):
Children: 0.6 mg/kg/day or 20 mg/m2/day divided in 3 to 4 doses/day
Less than 2 years: Do not exceed 1.25 mg/single dose
2 to 12 years: Do not exceed 5 mg/single dose
Greater than 12 years: Do not exceed 10 mg/single dose

Analgesic: Children: Dose has not been well established:
Opioid-naive patients (dose based on hydrocodone):
Children and Adults less than 50 kg: Usual initial dose: 0.1 to 0.2 mg/kg every 3 to 4 hours
Children and Adults greater than or equal to 50 kg: Usual initial dose: 5 to 10 mg every 3 to 4 hours

Renal Dose Adjustments

Dosage adjustments in patients with renal dysfunction should be done cautiously.

Liver Dose Adjustments

Dosage adjustments in patients with liver dysfunction should be done cautiously.

Dose Adjustments

Dosage can be titrated to achieve desired effect. Selected patients may benefit from formulations that provide more acetaminophen or more hydrocodone per dose.

In children, whenever possible calculate dose using weight.

Precautions

Hydrocodone, particularly in large doses, may cause life-threatening respiratory depression. Treatment includes maintenance of the airway, artificial ventilation if necessary, and the opiate antagonist, naloxone. The usual adult dose of naloxone is 1 to 2 mg every 2 to 3 minutes as necessary. The dose can be administered intravenously (preferred), intramuscularly, subcutaneously and sublingually.

Hydrocodone, like other analgesics, should be administered with caution to patients with head injuries, acute undiagnosed abdominal pain, acute alcoholism, delirium tremens, hypothyroidism, severe renal disease, severe liver disease, pulmonary disease, myxedema (or hypothyroidism), CNS depression, coma, toxic psychosis, Addison's disease, gall bladder disease, prostatic hypertrophy, urethral stricture, kyphoscoliosis, and general debilitation. Hydrocodone should also be administered with caution to patients following gastrointestinal surgery.

Hydrocodone, like other narcotic analgesics, may be habit forming.

Hydrocodone may impair the mental abilities necessary for potentially hazardous tasks such as driving or operating machinery.

The CNS depressant effects of hydrocodone may be increased by other CNS depressants such as alcohol, sedatives, hypnotics, tranquilizers, phenothiazines, and general anesthetics.

Dialysis

Dosage adjustments in dialysis patients should be done cautiously.

Other Comments

The FDA has asked manufacturers to limit the maximum amount of acetaminophen in prescription products to 325 mg per dosage unit. There are no data that indicate that taking more than 325 mg of acetaminophen per dosage unit provides more pain relief. The goal of the FDA is to reduce the risk of severe liver injury from acetaminophen overdose, which can lead to liver failure, liver transplant, and even death. The total number of units that may be prescribed and the time intervals for dosing will not change. Drug companies will have until January 14, 2014 to comply with FDA requirements.

Usual acetaminophen maximum dosage is 4 g per day.

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