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Thiotepa

Generic Name: thiotepa (thye-oh-TEP-a)
Brand Name: Generic only. No brands available.

Thiotepa is used for:

Treating certain types of cancers, including cancer of the breast, ovaries, and bladder. It may also be used for other conditions as determined by your doctor.

Thiotepa is an antineoplastic. It works by killing cancer cells.

Do NOT use thiotepa if:

  • you are allergic to any ingredient in thiotepa

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Flashback: FDA Drug Approvals 2013

Before using thiotepa:

Some medical conditions may interact with thiotepa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney or liver problems, bone marrow problems, or agranulocytosis
  • if you are receiving radiation therapy

Some MEDICINES MAY INTERACT with thiotepa. However, no specific interactions with thiotepa are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if thiotepa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use thiotepa:

Use thiotepa as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Thiotepa is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using thiotepa at home, carefully follow the injection procedures taught to you by your health care provider.
  • If thiotepa spills on your skin, immediately wash it off with soap and water.
  • If thiotepa contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of thiotepa, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use thiotepa.

Important safety information:

  • Thiotepa may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to thiotepa. Using thiotepa alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
  • Thiotepa may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
  • Thiotepa may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking thiotepa. Vaccinations may be less effective.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using thiotepa.
  • Thiotepa may decrease the effectiveness of your birth control pill. To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using thiotepa.
  • LAB TESTS, including liver function, kidney function, and white blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Thiotepa is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Thiotepa has been shown to cause harm to the fetus. Avoid becoming pregnant while taking thiotepa. If you think you may be pregnant, discuss with your doctor the benefits and risks of using thiotepa during pregnancy. It is unknown if thiotepa is excreted in breast milk. Do not breast-feed while taking thiotepa.

Possible side effects of thiotepa:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; hair loss; headache; loss of appetite; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black stools; change in the color of urine; chills, fever, or sore throat; cough; irregular or absent menstrual periods; nosebleed; pain at the injection site; unusual bruising or bleeding; unusual tiredness or weakness; urination problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of thiotepa:

Thiotepa is usually handled and stored by a health care provider. If you are using thiotepa at home, store thiotepa as directed by your pharmacist or health care provider. Keep thiotepa out of the reach of children and away from pets.

General information:

  • If you have any questions about thiotepa, please talk with your doctor, pharmacist, or other health care provider.
  • Thiotepa is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take thiotepa or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about thiotepa. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to thiotepa. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using thiotepa.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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