Skip to main content

Thiotepa Dosage

Medically reviewed by Drugs.com. Last updated on Aug 14, 2023.

Applies to the following strengths: 15 mg; 30 mg; 100 mg

Usual Adult Dose for Breast Cancer

0.3 to 0.4 mg/kg by rapid IV administration once every 1 to 4 weeks

Comments:


Use: Adenocarcinoma of the breast

Usual Adult Dose for Ovarian Cancer

0.3 to 0.4 mg/kg by rapid IV administration once every 1 to 4 weeks

Comments:


Use: Adenocarcinoma of the ovary

Usual Adult Dose for Serosal Cavity Neoplastic Disease

0.6 to 0.8 mg/kg by intracavitary injection once

Comments:


Use: For controlling intracavitary effusions secondary to diffuse or localized neoplastic diseases of various serosal cavities

Usual Adult Dose for Bladder Cancer

30 to 60 mg by intravesical instillation into the bladder once; for maximum effect, the solution should be retained for 2 hours; if the patient cannot retain 60 mL for 2 hours, the dose may be given in a volume of 30 mL


Comments:

Use: For the treatment of superficial papillary carcinoma of the urinary bladder

Renal Dose Adjustments

The manufacturer states that therapy is probably contraindicated in cases of existing renal damage; however, if the need outweighs the risk this drug may be used in low dosage, accompanied by appropriate testing.

Liver Dose Adjustments

The manufacturer states that therapy is probably contraindicated in cases of existing hepatic damage; however, if the need outweighs the risk this drug may be used in low dosage, accompanied by appropriate testing.

Dose Adjustments

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug is dialyzable; however, the manufacturer does not specify dosing instructions for dialysis patients.

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.