Oxymetholone

Generic Name: oxymetholone (ox-i-METH-oh-lone)
Brand Name: Anadrol-50

Oxymetholone may cause serious liver and spleen problems, including the formation of blood-filled cysts within the liver and spleen and the formation of liver tumors. Liver failure or severe internal bleeding may sometimes result. If you develop sudden dizziness, weakness, fainting, nausea, vomiting, stomach pain, dark urine, or yellowing of the skin or eyes, contact your doctor immediately.

Oxymetholone may cause changes in lipid levels in the blood, which can affect your risk of developing blockages in the arteries (atherosclerosis) or coronary artery disease. Talk with your doctor if you have questions about taking oxymetholone.


Oxymetholone is used for:

Treating certain types of anemia. It may also be used for other conditions as determined by your doctor.

Oxymetholone is an androgen hormone. It works by increasing the production of erythropoietin, a chemical in the body that increases the production of red blood cells.

Do NOT use oxymetholone if:

  • you are allergic to any ingredient in oxymetholone
  • you are or may become pregnant
  • you have severe kidney problems (eg, nephrosis) or severe liver problems or have cancer of the prostate or breast

Contact your doctor or health care provider right away if any of these apply to you.

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Before using oxymetholone:

Some medical conditions may interact with oxymetholone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diabetes; an enlarged prostate; heart, kidney, or liver problems; or high blood calcium

Some MEDICINES MAY INTERACT with oxymetholone. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), carbamazepine, insulin, or oxyphenbutazone because the risk of side effects may be increased by oxymetholone

This may not be a complete list of all interactions that may occur. Ask your health care provider if oxymetholone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use oxymetholone:

Use oxymetholone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Oxymetholone may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • If you miss a dose of oxymetholone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use oxymetholone.

Important safety information:

  • Diabetes patients - Oxymetholone may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • LAB TESTS, including blood cholesterol and lipid levels, iron levels, urine and blood calcium levels, liver function tests, bone growth and development, and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use oxymetholone with caution in the ELDERLY because they may be more sensitive to its effects, especially enlarged prostate and prostate cancer.
  • Oxymetholone may affect certain lab tests, including thyroid function tests. Be sure your doctors and lab personnel know you are taking oxymetholone.
  • Oxymetholone may affect the growth rate in CHILDREN and adolescents in some instances. Your child's growth may need to be checked regularly while using oxymetholone.
  • Caution is advised when using oxymetholone in CHILDREN because they may be more sensitive to its effects, especially effects on bone growth and sexual development.
  • PREGNANCY and BREAST-FEEDING: Do not use oxymetholone if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if oxymetholone is excreted in breast milk. Do not breast-feed while using oxymetholone.

Possible side effects of oxymetholone:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; acne; anxiety; baldness; changes in sexual desire; general body discomfort; headache.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast growth; changes in menstrual periods; changes in skin color; deepening of the voice; depression; frequent or persistent erections; hoarseness; mood or mental problems; more hair on the face; nausea; new lumps or pain; swelling of arms or legs; trouble sleeping; trouble urinating; unusual bruising or bleeding; vomiting; weight gain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of oxymetholone:

Store oxymetholone between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep oxymetholone out of the reach of children and away from pets.

General information:

  • If you have any questions about oxymetholone, please talk with your doctor, pharmacist, or other health care provider.
  • Oxymetholone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take oxymetholone or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about oxymetholone. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to oxymetholone. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using oxymetholone.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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