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Generic Name: pramipexole (PRAM-i-PEX-ole)
Brand Name: Mirapex

Mirapex is used for:

Treating the signs and symptoms of Parkinson disease. It is also used to treat restless legs syndrome (RLS). It may also be used for other conditions as determined by your doctor.

Mirapex is a dopamine agonist. Exactly how Mirapex works is not known. It may increase the action of certain chemical receptors in the brain.

Do NOT use Mirapex if:

  • you are allergic to any ingredient in Mirapex
  • you are taking another medicine that has pramipexole in it

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Parkinson’s Disease - 10 Clinical Fast Facts

Before using Mirapex:

Some medical conditions may interact with Mirapex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems, low blood pressure, dizziness or fainting when you sit or stand up, or sleep problems (eg, daytime sleepiness)
  • if you drink alcohol or have a history of compulsive behavior (eg, eating, gambling, shopping)
  • if you have trouble controlling your muscles

Some MEDICINES MAY INTERACT with Mirapex. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cimetidine because it may increase the risk of Mirapex's side effects
  • Butyrophenones (eg, haloperidol), metoclopramide, phenothiazines (eg, chlorpromazine), or thioxanthenes (eg, thiothixene) because they may decrease Mirapex's effectiveness
  • Levodopa because the risk of its side effects may be increased by Mirapex

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mirapex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mirapex:

Use Mirapex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Mirapex. Talk to your pharmacist if you have questions about this information.
  • Take Mirapex by mouth with or without food. If nausea occurs, take with food to reduce nausea.
  • If you are taking Mirapex for RLS, you should take Mirapex 2 to 3 hours before bedtime, unless your doctor tells you otherwise.
  • Your dose will be started low and gradually increased to achieve the best results. Do not change your dose sooner than recommended.
  • Do not suddenly stop taking Mirapex without checking with your doctor. Severe side effects, including fever, confusion, and stiff muscles, may occur. If you need to stop Mirapex, your doctor will gradually lower your dose.
  • If you miss a dose of Mirapex, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss several doses, contact your doctor before you start to take Mirapex again.

Ask your health care provider any questions you may have about how to use Mirapex.

Important safety information:

  • Mirapex may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Mirapex with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using Mirapex.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Mirapex; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Mirapex may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Some patients who take Mirapex have reported suddenly falling asleep while performing daily activities (eg, driving, eating, talking). Some patients did not experience drowsiness and felt that they were alert immediately before suddenly falling asleep. Some of these events have been reported as late as 1 year after Mirapex was started. Use caution when driving, operating machinery, or performing other activities that could be dangerous. Inform your doctor if you experience unusual drowsiness or sleepiness while using Mirapex.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • In patients with RLS, Mirapex may cause a worsening of RLS symptoms or cause symptoms to occur earlier in the day (afternoon or evening) or spread to other extremities. Discuss any questions or concerns with your doctor.
  • Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Mirapex. Tell your doctor right away if you or a caregiver notice such effects.
  • Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if Mirapex also increases the risk of melanoma. You may need to have skin exams while you are using Mirapex. Discuss any questions or concerns with your doctor.
  • Tell your doctor or dentist that you take Mirapex before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including blood pressure or skin checks, may be performed while you use Mirapex. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Mirapex with caution in the ELDERLY; they may be more sensitive to its effects, especially hallucinations.
  • Mirapex should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Mirapex while you are pregnant. It is not known if Mirapex is found in breast milk. Do not breast-feed while taking Mirapex.

Possible side effects of Mirapex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal dreams; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; stuffy nose; tiredness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; balance problems; change in the amount of urine produced; change in behavior, mood, or emotions; chest pain; confusion; dark urine; decreased sexual ability; difficulty walking; fainting; hallucinations; memory problems; muscle pain, tenderness, or weakness; new or unusual skin growths or change in the appearance of a mole; severe or persistent dizziness, drowsiness, or sleepiness; shortness of breath; sudden irresistible urge to sleep or suddenly falling asleep at unusual times; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; trouble swallowing; unusual or intense urges (eg, gambling, sexual urges); unusual twitching or muscle movements; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fast heartbeat.

Proper storage of Mirapex:

Store Mirapex at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mirapex out of the reach of children and away from pets.

General information:

  • If you have any questions about Mirapex, please talk with your doctor, pharmacist, or other health care provider.
  • Mirapex is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Mirapex or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Mirapex. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Mirapex. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Mirapex.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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