Generic Name: hydrochlorothiazide (HYE-droe-KLOR-oh-THYE-a-zide)
Brand Name: Microzide
Microzide is used for:
Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.
Microzide is a thiazide diuretic. It works by helping the kidneys to remove fluid from the body.
Do NOT use Microzide if:
- you are allergic to any ingredient in Microzide or to another sulfonamide medicine (eg, sulfamethoxazole)
- you are unable to urinate
- you are taking dofetilide or ketanserin
Contact your doctor or health care provider right away if any of these apply to you.
Before using Microzide:
Some medical conditions may interact with Microzide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of gout, liver problems, (eg, cirrhosis), lupus, kidney problems, diabetes or high blood sugar, asthma, parathyroid gland problems, or high blood cholesterol or lipid levels
- if you have high or low blood electrolyte levels (eg, sodium, potassium, magnesium, calcium)
- if you are taking another medicine for high blood pressure
Some MEDICINES MAY INTERACT with Microzide. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased
- Barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), corticotropin, other diuretics (eg, furosemide), or narcotic pain medicines (eg, codeine) because they may increase the risk of Microzide's side effects
- Cholestyramine, colestipol, or nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) because they may decrease Microzide's effectiveness
- Diazoxide or lithium because the risk of their side effects may be increased by Microzide
- Diabetes medicines (eg, glipizide, metformin) or insulin because their effectiveness may be decreased by Microzide
This may not be a complete list of all interactions that may occur. Ask your health care provider if Microzide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Microzide:
Use Microzide as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Microzide by mouth with or without food.
- If you take colestipol or cholestyramine for high cholesterol, ask your doctor or pharmacist how to take it with Microzide.
- Microzide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
- If you miss a dose of Microzide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Microzide.
Important safety information:
- Microzide may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Microzide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Microzide may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Report any light-headedness or fainting to your doctor immediately. Your risk of light-headedness or fainting may be increased if you experience diarrhea, vomiting, or excessive sweating; if you do not drink enough fluids; or if you are on a low-salt (sodium) diet. Contact your health care provider at once if any of these events occur.
- Microzide is a sulfonamide. It can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (eg, sulfamethoxazole) or to penicillin antibiotics (eg, amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Microzide. Contact your doctor right away if you experience symptoms such as vision changes (eg, decreased vision clearness) or eye pain.
- Your doctor may also prescribe a potassium supplement for you. If so, take the potassium supplement exactly as prescribed. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.
- Tell your doctor or dentist that you take Microzide before you receive any medical or dental care, emergency care, or surgery.
- Tell your doctor if you will be exposed to high temperatures. The risk of certain side effects (eg, low blood sodium levels) may be increased in hot weather.
- Microzide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Microzide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
- Microzide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Microzide may interfere with certain lab tests, including parathyroid function. Be sure your doctor and lab personnel know you are taking Microzide.
- Lab tests, including kidney function, blood pressure, and electrolyte levels, may be performed while you take Microzide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Microzide with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness.
- Microzide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Microzide may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Microzide while you are pregnant. Microzide is found in breast milk. If you are or will be breast-feeding while you take Microzide, check with your doctor. Discuss any possible risks to your baby. Do not breast-feed while taking Microzide.
Possible side effects of Microzide:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; diarrhea; dizziness; light-headedness; loss of appetite; nausea; temporary blurred vision.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; eye pain; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased thirst; joint pain, swelling, warmth, or redness (especially of the big toe joint); muscle pain, weakness, or cramps; numbness or tingling; red, swollen, blistered, or peeling skin; severe or persistent dizziness or light-headedness; severe or persistent nausea or stomach pain; shortness of breath; symptoms of low blood sodium levels (eg, confusion, mental or mood changes, seizures, sluggishness); unusual bruising or bleeding; unusual drowsiness, restlessness, tiredness, or weakness; unusually dry mouth; vision changes (eg, decreased vision clearness); vomiting; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe dizziness; symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness); symptoms of dehydration (eg, dry mouth or eyes; decreased urination; fast heartbeat; unusual thirst, tiredness, or weakness).Proper storage of Microzide:
Store Microzide at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Microzide out of the reach of children and away from pets.
- If you have any questions about Microzide, please talk with your doctor, pharmacist, or other health care provider.
- Microzide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Microzide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Microzide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Microzide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Microzide.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More Microzide resources
- Microzide Advanced Consumer (Micromedex) - Includes Dosage Information
- Microzide Concise Consumer Information (Cerner Multum)
- Microzide Prescribing Information (FDA)
- Hydrochlorothiazide Prescribing Information (FDA)
- Hydrochlorothiazide Professional Patient Advice (Wolters Kluwer)
- Hydrochlorothiazide Monograph (AHFS DI)
- Esidrix Prescribing Information (FDA)