Hydrocodone/ homatropine syrup

Generic Name: hydrocodone/homatropine (HIGH-droe-KOE-dohn/hoe-MA-troe-peen)
Brand Name: Examples include Hycodan and Hydromet

Hydrocodone/ homatropine syrup is used for:

Temporary relief of cough. It may also be used for other conditions as determined by your doctor.

Hydrocodone/homatropine syrup is an anticholinergic and narcotic cough suppressant combination. The anticholinergic works by drying up secretions and the narcotic depresses the cough reflex in the brain.

Do NOT use hydrocodone/ homatropine syrup if:

  • you are allergic to any ingredient in hydrocodone/homatropine syrup or any morphine-related medicine (eg, codeine, oxycodone)
  • you have diarrhea due to food poisoning or pseudomembranous colitis
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using hydrocodone/ homatropine syrup:

Some medical conditions may interact with hydrocodone/homatropine syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine (including any cough-and-cold products or medicines that cause drowsiness), herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have arteriosclerosis (hardening of the arteries) or other heart problems (eg, congestive heart failure)
  • if you have high blood pressure, thyroid problems, stomach problems (eg, surgery, severe inflammatory bowel disease, chronic constipation, obstruction), or liver disease
  • if you use alcohol or are dependent on drugs
  • if you have lung disease (eg, asthma, history of severe breathing problems), a seizure disorder, serious head injury or brain disease, psychiatric problems (eg, suicidal thoughts), glaucoma, or sleep apnea

Some MEDICINES MAY INTERACT with hydrocodone/homatropine syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Barbiturate anesthetics (eg, thiopental), cimetidine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), narcotic pain medicines (eg, codeine), and sodium oxybate (GHB) because they may increase the risk of hydrocodone/homatropine syrup's side effects
  • Naltrexone because it may decrease hydrocodone/homatropine syrup's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if hydrocodone/homatropine syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use hydrocodone/ homatropine syrup:

Use hydrocodone/homatropine syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take hydrocodone/homatropine syrup by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of hydrocodone/homatropine syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use hydrocodone/homatropine syrup.

Important safety information:

  • Hydrocodone/homatropine syrup may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use hydrocodone/homatropine syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If your symptoms do not get better within 7 days or if you develop a high fever or persistent headache, check with your doctor.
  • Hydrocodone/homatropine syrup may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking hydrocodone/homatropine syrup.
  • Use hydrocodone/homatropine syrup with caution in the ELDERLY; they may be more sensitive to its effects.
  • Hydrocodone/homatropine syrup should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if hydrocodone/homatropine syrup can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using hydrocodone/homatropine syrup while you are pregnant. It is not known if hydrocodone/homatropine syrup is found in breast milk. Do not breast-feed while taking hydrocodone/homatropine syrup.

Some people who use hydrocodone/homatropine syrup for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking hydrocodone/homatropine syrup suddenly, you may have WITHDRAWAL symptoms. These may include feeling unwell or unhappy, anxious or irritable, dizzy, confused, or agitated. You may also have nausea, unusual skin sensations, mood swings, headache, trouble sleeping, or sweating. If you need to stop hydrocodone/homatropine syrup, your doctor will lower your dose over time.

Possible side effects of hydrocodone/ homatropine syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dizziness; drowsiness; dry mouth, throat, or nose; excitement; nausea; stomach upset; thickening or mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; flushing; rapid or pounding heartbeat; redness of face; severe drowsiness or dizziness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; coma; confusion; deep sleep or loss of consciousness; difficulty breathing; diminished mental alertness; hallucinations; hot or cold skin; large and unchanging pupils; sedation; seizures; shaking; sleeplessness; slow heartbeat; slowed breathing.

Proper storage of hydrocodone/homatropine syrup:

Store hydrocodone/homatropine syrup at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep hydrocodone/homatropine syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about hydrocodone/homatropine syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Hydrocodone/homatropine syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take hydrocodone/homatropine syrup or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hydrocodone/homatropine syrup. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hydrocodone/homatropine syrup. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hydrocodone/homatropine syrup.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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