Eletriptan

Generic Name: eletriptan (EL-e-TRIP-tan)
Brand Name: Relpax

Eletriptan is used for:

Treating migraine headaches with or without aura (flashing lights, wavy lines, dark spots) in adults. It is not used to prevent migraines. It may also be used for other conditions as determined by your doctor.

Eletriptan is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing blood vessels in the brain, which helps to relieve migraines.

Do NOT use eletriptan if:

  • you are allergic to any ingredient in eletriptan
  • you have uncontrolled high blood pressure or severe liver problems
  • you have certain types of irregular heartbeat (eg, Wolff-Parkinson-White syndrome)
  • you have or have had hemiplegic or basilar migraine headaches
  • you have a history of ischemic heart disease (eg, angina, heart attack), coronary artery disease (CAD), brain blood vessel disease (eg, stroke, transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)
  • you have taken ketoconazole, itraconazole, ritonavir, nelfinavir, clarithromycin, troleandomycin, or nefazodone within the last 72 hours
  • you have used an ergot alkaloid (eg, dihydroergotamine, ergotamine) or another "triptan" migraine medicine (eg, sumatriptan) in the last 24 hours

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Living with Your Migraines: Tips for Treatment and Prevention

Before using eletriptan:

Some medical conditions may interact with eletriptan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have gone through menopause or have had a hysterectomy
  • if you are a male who is older than 40 years old
  • if you have a history of heart problems (eg, irregular heartbeat), high blood pressure, high cholesterol, liver or kidney problems, diabetes, or other types of headaches (eg, cluster headaches)
  • if you are overweight or if you smoke
  • if a member of your family has had heart problems, blood vessel problems, or a stroke

Some MEDICINES MAY INTERACT with eletriptan. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) or serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine) because the risk of a serious side effect called serotonin syndrome may be increased
  • Clarithromycin, ergot alkaloids (eg, dihydroergotamine, ergotamine), itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, telithromycin, troleandomycin, verapamil, or another 5-HT1 agonist (eg, sumatriptan) because they may increase the risk of eletriptan's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if eletriptan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use eletriptan:

Use eletriptan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with eletriptan. Talk to your pharmacist if you have questions about this information.
  • Take eletriptan by mouth with or without food.
  • It is best to take a dose of eletriptan as soon as you notice symptoms of a migraine attack.
  • If your migraine symptoms go away and then come back, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.
  • If your symptoms do NOT improve after the first dose, do not take a second dose for the same attack. Contact your doctor.
  • Do not take more than the amount prescribed by your doctor in a 24-hour period or treat more than 3 headaches within 30 days without checking with your doctor.
  • If you miss a dose of eletriptan and you still have a headache, follow your doctor's dosing instructions. Contact your doctor if you are unsure what to do if you miss a dose. Do not take eletriptan more often then prescribed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use eletriptan.

Important safety information:

  • Eletriptan may cause dizziness, drowsiness, or weakness. These effects may be worse if you take it with alcohol or certain medicines. Use eletriptan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Overuse of eletriptan can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
  • Eletriptan should not be used to prevent or reduce the number of migraine headaches you have. If you have a headache that is different than your usual migraine headaches, check with your doctor before using eletriptan.
  • Rarely, serious heart problems (eg, heart attack, irregular heartbeat) have been reported within a few hours of using eletriptan. Contact your doctor at once if fast or irregular heartbeat; chest, jaw, or neck pain or numbness; sudden, severe nausea or vomiting; sudden, unusual sweating or weakness; shortness of breath; fainting; or vision changes occur. Discuss any questions or concerns with your doctor.
  • Serotonin syndrome is a possibly fatal syndrome that can be caused by eletriptan. Your risk may be greater if you take eletriptan with certain other medicines (eg, SSRIs, SNRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • Use eletriptan with caution in the ELDERLY; they may be more sensitive to its effects.
  • Eletriptan should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if eletriptan can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using eletriptan while you are pregnant. Eletriptan is found in breast milk. If you are or will be breast-feeding while you use eletriptan, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of eletriptan:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; nausea; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; burning or pain in the feet or toes; fainting; fast or irregular heartbeat; numbness and tingling of hands or feet; pain, tightness, or pressure in the jaw, throat, neck, or chest; pain or cramps in the legs or hips; pounding in the chest; severe or persistent constipation or diarrhea; severe or persistent dizziness; shortness of breath; stomach pain; symptoms of a heart attack (eg, chest pain; numbness of an arm or leg; sudden, severe headache or vomiting; vision changes); symptoms of a stroke (eg, confusion, one-sided weakness, slurred speech, vision changes); unusual or worsening headache; very cold or blue fingers or toes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of eletriptan:

Store eletriptan at room temperature between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep eletriptan out of the reach of children and away from pets.

General information:

  • If you have any questions about eletriptan, please talk with your doctor, pharmacist, or other health care provider.
  • Eletriptan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take eletriptan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about eletriptan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to eletriptan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using eletriptan.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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