Allergies? Get expert advice on treating severe allergies and anaphylaxis.

Generic Name: danazol (DAN-a-zol)
Brand Name: Generic only. No brands available.

Do not use danazol if you are pregnant. It may cause serious harm to a fetus. It is recommended that a pregnancy test be performed before starting danazol. Effective, nonhormonal birth control measures, such as diaphragms and condoms, should be used while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol. If you become pregnant while taking danazol, stop use and contact your doctor right away.

Serious and sometimes fatal blood clots (eg, stroke), increased pressure in the head, and liver problems have been reported with the use of danazol. Notify your doctor immediately if you develop any of the following: calf or leg pain, redness, tenderness, or swelling; chest pain; fainting; headache; nausea or vomiting; shortness of breath; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness); symptoms of stroke (eg, one-sided weakness, slurred speech, confusion); vision changes.


Danazol is used for:

Treating certain types of endometriosis or fibrocystic breast disease. It is also used to prevent attacks of hereditary angioedema (HAE). It may also be used for other conditions as determined by your doctor.

Danazol is a synthetic steroid. It works by decreasing the level of certain hormones, which reduces the symptoms and severity of the diseases treated by danazol.

Do NOT use danazol if:

  • you are allergic to any ingredient in danazol
  • you are pregnant or are breast-feeding
  • you have undiagnosed abnormal vaginal bleeding
  • you have the blood disease porphyria; an androgen-dependent tumor; or severe liver, kidney, or heart problems
  • you have a blood clot, are at risk for blood clots, or have a history of blood clots or stroke
  • you take simvastatin

Contact your doctor or health care provider right away if any of these apply to you.

Video: Asthma

How to prevent and treat an asthma attack.

Before using danazol:

Some medical conditions may interact with danazol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of the blood disease polycythemia, blood vessel problems, cancer (eg, breast cancer), diabetes, seizures, fluid retention (swelling), heart problems (eg, heart failure, heart disease), high blood pressure, high cholesterol levels, liver or kidney problems, or migraines

Some MEDICINES MAY INTERACT with danazol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), carbamazepine, cyclosporine, sirolimus, certain statins (eg, atorvastatin, lovastatin, simvastatin), or tacrolimus because the risk of their side effects may be increased by danazol
  • Insulin or other diabetes medicines (eg, glipizide) because their effectiveness may be decreased by danazol

This may not be a complete list of all interactions that may occur. Ask your health care provider if danazol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use danazol:

Use danazol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take danazol by mouth with or without food.
  • If you are being treated for endometriosis or fibrocystic breast disease, you should begin treatment during menstruation.
  • Endometriosis patients - You must take danazol consistently for 3 to 6 months. It may be necessary to take danazol for 9 months.
  • If you miss a dose of danazol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use danazol.

Important safety information:

  • Danazol may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use danazol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more medicine than prescribed unless advised to do so by your doctor.
  • It may take several months for danazol to work. Do not stop using danazol without checking with your doctor.
  • Women who may become pregnant must have a negative pregnancy test before beginning treatment with danazol.
  • Use a barrier method of birth control, such as a condom or diaphragm, while taking danazol. Talk with your doctor about the use of effective birth control while you use danazol.
  • If you are taking danazol for fibrocystic breast disease, you should have a breast exam before starting it. Contact your doctor right away if you experience new or persistent breast pain, tenderness, or lumps while taking danazol.
  • Tell your doctor or dentist that you take danazol before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Danazol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Danazol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking danazol.
  • Lab tests, including liver function tests and complete blood cell counts, may be performed while you use danazol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Danazol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use danazol if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if danazol is found in breast milk. Do not breast-feed while taking danazol.

Possible side effects of danazol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; changes in menstrual flow (eg, spotting); changes in semen volume; decrease in breast size; excessively oily skin; flushing; hair loss; mild weight gain; sweating; vaginal itching or dryness; voice changes (hoarseness, sore throat, change in pitch).

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes (eg mood swings, nervousness); nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness); symptoms of stroke (eg, one-sided weakness, slurred speech, confusion); unusual bleeding or bruising; vision problems; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of danazol:

Store danazol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep danazol out of the reach of children and away from pets.

General information:

  • If you have any questions about danazol, please talk with your doctor, pharmacist, or other health care provider.
  • Danazol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take danazol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about danazol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to danazol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using danazol.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Watch this video series to learn about managing severe allergies (anaphylaxis).

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