Danazol Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Endometriosis

100 mg to 200 mg orally two times a day.

Severe cases of endometriosis may require an initial dosage of 400 mg orally two times a day.

To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non-hormonal birth control method is recommended.

Following an initial favorable response (amenorrhea develops), the dosage should be titrated to the minimum dose that suppresses disease activity.

Therapy should continue uninterrupted for 3 to 6 months. Administration of danazol up to 9 months may be necessary. Should symptoms recur, danazol treatment may be reinitiated.

Usual Adult Dose for Fibrocystic Breast Disease

50 mg to 200 mg orally two times a day.

To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended.

Resolution of pain and tenderness usually occurs following 1 to 3 months of therapy. Elimination of nodules often requires 4 to 6 months of uninterrupted therapy. Symptoms recur within one year in 50% of patients and therapy may be reinitiated if necessary.

Usual Adult Dose for Angioedema

200 mg orally two to three times a day.

To assure a female patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended.

Following an initial favorable response (prevention of edematous episodes), attempts should be made at 1 to 3 month intervals to reduce the dosage to the minimum continuous dose that will prevent angioedema. Dosage reductions up to 50% per interval may be considered. Should angioedema recur, the daily dosage may be increased up to 200 mg.

Renal Dose Adjustments

The use of danazol is not recommended in patients with severe renal dysfunction. The normal dosage recommendation may be considered if the patient's renal dysfunction is mild to moderate. Monitoring of renal function is recommended.

Liver Dose Adjustments

The use of danazol is not recommended in patients with severe hepatic dysfunction. The normal dosage recommendation may be considered if the hepatic dysfunction is mild to moderate. Monitoring of liver function is recommended.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

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