Cycloserine

Generic Name: cycloserine (sigh-kloe-SER-een)
Brand Name: Seromycin

Cycloserine is used for:

Treating tuberculosis (TB) in the lungs and other places in the body (including the kidneys) when treatment with other medicines has not been effective. Cycloserine should be used in combination with other medicines. It may also be used to treat certain urinary tract infections.

Cycloserine is an antibiotic. It works by blocking the growth of the bacterial cell wall.

Do NOT use cycloserine if:

  • you are allergic to any ingredient in cycloserine
  • you have depression, severe anxiety, psychosis (bizarre behavior or thoughts), epilepsy, or severe kidney problems
  • you have alcoholism or you drink excessive amounts of alcohol

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

Before using cycloserine:

Some medical conditions may interact with cycloserine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you regularly consume alcoholic beverages or have a history of alcoholism
  • if you have anxiety, kidney or liver problems, or the blood disease porphyria

Some MEDICINES MAY INTERACT with cycloserine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Ethionamide because the risk of toxic side effects may be increased
  • Isoniazid because the risk of side effects such as drowsiness or dizziness may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if cycloserine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use cycloserine:

Use cycloserine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cycloserine may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • To clear up your infection completely, continue to use cycloserine even if you feel well. Do not miss any doses.
  • If you miss a dose of cycloserine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use cycloserine.

Important safety information:

  • Cycloserine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to cycloserine. Using cycloserine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Do not drink alcohol while you are using cycloserine.
  • Cycloserine is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold)
  • It is important to use cycloserine for the full course of treatment. Failure to do so may decrease the effectiveness of cycloserine and increase the risk that the bacteria will no longer be sensitive to cycloserine and will not be able to be treated by this or certain other antibiotics in the future.
  • Long-term or repeated use of cycloserine may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
  • LAB TESTS, including complete blood cell counts, kidney and liver function, and the level of cycloserine in the blood, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use cycloserine with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if cycloserine can cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using cycloserine during pregnancy. Cycloserine is excreted in breast milk. Do not breast feed while taking cycloserine.

Possible side effects of cycloserine:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); aggression; bizarre behavior; coma; confusion; depression; disorientation; dizziness; drowsiness; exaggerated reflexes; excessive irritability; feeling of a whirling motion; headache; memory loss; mental or mood changes; mood swings; numbness or tingling of the skin; paralysis; seizures; slurred speech or other speech problems; swelling of the hands or feet; tremors; thoughts of suicide; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include abnormal skin sensations; bizarre thoughts or behavior; confusion; dizziness; drowsiness; excessive irritability; feeling of a whirling motion; headache; hyperirritability; loss of consciousness; paralysis; seizures; slurred speech.

Proper storage of cycloserine:

Store cycloserine at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep cycloserine out of the reach of children and away from pets.

General information:

  • If you have any questions about cycloserine, please talk with your doctor, pharmacist, or other health care provider.
  • Cycloserine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take cycloserine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about cycloserine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to cycloserine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using cycloserine.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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