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cycloserine (Oral route)

sye-kloe-SER-een

Commonly used brand name(s)

In the U.S.

  • Seromycin

Available Dosage Forms:

  • Capsule

Therapeutic Class: Antitubercular

Uses For cycloserine

Cycloserine belongs to the family of medicines called antibiotics. It is used to treat tuberculosis (TB). When cycloserine is used for TB, it is given with other medicines for TB. Cycloserine may also be used for other conditions as determined by your doctor.

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To help clear up your tuberculosis (TB) completely, you must keep taking cycloserine for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.

Cycloserine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, cycloserine is used in certain patients with the following medical condition:

  • Atypical mycobacterial infections, such as Mycobacterium avium complex (MAC)

Before Using cycloserine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cycloserine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to cycloserine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of cycloserine in children with use in other age groups, cycloserine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of cycloserine in the elderly with use in other age groups, cycloserine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using cycloserine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of cycloserine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Convulsive disorders such as seizures or epilepsy—Cycloserine may increase the risk of seizures in patients who drink alcohol or have a history of seizures
  • Kidney disease—Cycloserine is removed from the body through the kidneys, and patients with kidney disease may need an adjustment in dose or the medicine may need to be discontinued
  • Mental disorders such as mental depression, psychosis, or severe anxiety—Cycloserine may cause anxiety, mental depression, or psychosis

Proper Use of cycloserine

Cycloserine may be taken after meals if it upsets your stomach.

To help clear up your infection completely, it is very important that you keep taking cycloserine for the full time of treatment , even if you begin to feel better after a few weeks. If you are taking cycloserine for TB, you may have to take it every day for as long as 1 to 2 years or more. If you stop taking cycloserine too soon, your symptoms may return.

cycloserine works best when there is a constant amount in the blood or urine. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times day and night. For example, if you are to take 2 doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Dosing

The dose of cycloserine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of cycloserine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the oral dosage form (capsules):
    • For treatment of tuberculosis:
      • Adults and teenagers—250 milligrams (mg) two times a day to start. Your doctor may slowly increase your dose up to 250 mg three or four times a day. cycloserine must be taken along with other medicines to treat tuberculosis.
      • Children—Use and dose must be determined by your doctor. Doses of 10 to 20 mg per kilogram (4.5 to 9.1 mg per pound) of body weight per day have been used. cycloserine must be taken along with other medicines to treat tuberculosis.

Missed Dose

If you miss a dose of cycloserine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using cycloserine

It is very important that your doctor check your progress at regular visits.

If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

If cycloserine causes you to feel very depressed or to have thoughts of suicide, check with your doctor immediately. Your doctor will probably want to change your medicine.

cycloserine may cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to cycloserine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert. If these reactions are especially bothersome, check with your doctor.

Some of cycloserine's side effects (for example, convulsions [seizures]) may be more likely to occur if you drink alcoholic beverages regularly while you are taking cycloserine. Therefore, you should not drink alcoholic beverages while you are taking cycloserine.

cycloserine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Anxiety
  • confusion
  • dizziness
  • drowsiness
  • increased irritability
  • increased restlessness
  • mental depression
  • muscle twitching or trembling
  • nervousness
  • nightmares
  • other mood or mental changes
  • speech problems
  • thoughts of suicide
Less common
  • Convulsions (seizures)
  • numbness, tingling, burning pain, or weakness in the hands or feet
  • skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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