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Cycloserine Side Effects

Not all side effects for cycloserine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cycloserine: oral capsule

In addition to its needed effects, some unwanted effects may be caused by cycloserine. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking cycloserine:

More common
  • Anxiety
  • confusion
  • dizziness
  • drowsiness
  • increased irritability
  • increased restlessness
  • mental depression
  • muscle twitching or trembling
  • nervousness
  • nightmares
  • other mood or mental changes
  • speech problems
  • thoughts of suicide
Less common
  • Convulsions (seizures)
  • numbness, tingling, burning pain, or weakness in the hands or feet
  • skin rash

Some of the side effects that can occur with cycloserine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Headache

For Healthcare Professionals

Applies to cycloserine: oral capsule

General

Cycloserine is most frequently associated with neurotoxicity and hypersensitivity.

Nervous system

Nervous system side effects may be dose-related (> 500 mg/day) and have included convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, disorientation, loss of memory, psychoses, suicidal tendencies, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, major and localized seizures, and coma.

Hematologic

Hematologic side effects have included vitamin B12 deficiency, folic acid deficiency, megaloblastic anemia, and sideroblastic anemia.

Hepatic

Hepatic side effects have included elevated serum transaminases, particularly in patients with preexisting liver disease.

Hypersensitivity

Hypersensitivity reactions have included skin rash.

Cardiovascular

Cardiovascular side effects have included sudden development of congestive heart failure in patients receiving high doses (1 to 1.5 g/day).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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