Cycloserine Side Effects
Some side effects of cycloserine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cycloserine: oral capsule
Along with its needed effects, cycloserine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cycloserine:More common
- increased irritability
- increased restlessness
- mental depression
- muscle twitching or trembling
- other mood or mental changes
- speech problems
- thoughts of suicide
- Convulsions (seizures)
- numbness, tingling, burning pain, or weakness in the hands or feet
- skin rash
Some side effects of cycloserine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
For Healthcare Professionals
Applies to cycloserine: oral capsule
Cycloserine is most frequently associated with neurotoxicity and hypersensitivity.
Nervous system side effects may be dose-related (> 500 mg/day) and have included convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, disorientation, loss of memory, psychoses, suicidal tendencies, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, major and localized seizures, and coma.
Hematologic side effects have included vitamin B12 deficiency, folic acid deficiency, megaloblastic anemia, and sideroblastic anemia.
Hepatic side effects have included elevated serum transaminases, particularly in patients with preexisting liver disease.
Hypersensitivity reactions have included skin rash.
Cardiovascular side effects have included sudden development of congestive heart failure in patients receiving high doses (1 to 1.5 g/day).
More cycloserine resources
- cycloserine MedFacts Consumer Leaflet (Wolters Kluwer)
- cycloserine Advanced Consumer (Micromedex) - Includes Dosage Information
- cycloserine Concise Consumer Information (Cerner Multum)
- Cycloserine Professional Patient Advice (Wolters Kluwer)
- Cycloserine Monograph (AHFS DI)
- Seromycin Prescribing Information (FDA)
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