Cycloserine Side Effects

Some side effects of cycloserine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to cycloserine: oral capsule

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• seizures;

• numbness or tingling in your hands or feet;

• a skin rash;

• confusion or abnormal behavior;

• tremors (shaking);

• headache;

• drowsiness;

• dizziness;

• difficulty speaking; or

• irritability.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to cycloserine: oral capsule

General

Cycloserine is most frequently associated with neurotoxicity and hypersensitivity.

Nervous system

Nervous system side effects may be dose-related (> 500 mg/day) and have included convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, disorientation, loss of memory, psychoses, suicidal tendencies, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, major and localized seizures, and coma.

Hematologic

Hematologic side effects have included vitamin B12 deficiency, folic acid deficiency, megaloblastic anemia, and sideroblastic anemia.

Hepatic

Hepatic side effects have included elevated serum transaminases, particularly in patients with preexisting liver disease.

Hypersensitivity

Hypersensitivity reactions have included skin rash.

Cardiovascular

Cardiovascular side effects have included sudden development of congestive heart failure in patients receiving high doses (1 to 1.5 g/day).

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