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Amiloride

Pronunciation

Generic Name: amiloride (a-MILL-oh-ride)
Brand Name: Midamor

Amiloride may cause high blood potassium levels that can be fatal if not corrected. High blood potassium levels occur more commonly in patients with kidney problems, diabetes, elderly patients, those who are severely ill, or patients who are not taking an agent used to increase excretion of potassium. If you develop muscle weakness or irregular heartbeat, notify your doctor immediately.


Amiloride is used for:

Preventing development of low blood potassium or helping to restore normal blood potassium in patients with high blood pressure or heart failure. It is usually used with other medicines. It may also be used for other conditions as determined by your doctor.

Amiloride is a potassium-sparing diuretic. It works by making the kidneys eliminate sodium (salt) and water from the body while retaining potassium.

Do NOT use amiloride if:

  • you are allergic to any ingredient in amiloride
  • you are taking potassium supplements or potassium-sparing diuretics (eg, aldosterone, triamterene)
  • you are unable to urinate
  • you have high blood potassium levels or kidney problems due to diabetes or other severe kidney disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using amiloride:

Some medical conditions may interact with amiloride. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems, diabetes, kidney damage caused by diabetes, liver or kidney problems, low blood sodium levels, or a high acidity of body fluids, or you are dehydrated

Some MEDICINES MAY INTERACT with amiloride. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin II receptor antagonists (eg, valsartan), cyclosporine, other potassium-sparing diuretics (eg, aldosterone, triamterene) or potassium supplements because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of the limbs, slow or irregular heartbeat, or stopping of the heart
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease amiloride's effectiveness and increase the risk of kidney problems and high blood potassium levels
  • Lithium or quinidine because the risk of their side effects and toxicity may be increased by amiloride

This may not be a complete list of all interactions that may occur. Ask your health care provider if amiloride may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use amiloride:

Use amiloride as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take amiloride by mouth with food.
  • Amiloride may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of amiloride, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use amiloride.

Important safety information:

  • Amiloride may cause drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use amiloride with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Lab tests, including electrolyte levels and blood pressure monitoring, may be performed while you use amiloride. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use amiloride with caution in the ELDERLY; they may be more sensitive to its effects.
  • Amiloride should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using amiloride while you are pregnant. It is not known if amiloride is found in breast milk. Do not breast-feed while taking amiloride.

Possible side effects of amiloride:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; loss of appetite; nausea; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dry mouth; excessive thirst; slowed heart rate; unusual muscle weakness; unusual tiredness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include lightheadedness; nausea; vomiting; weakness.

Proper storage of amiloride:

Store amiloride at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep amiloride out of the reach of children and away from pets.

General information:

  • If you have any questions about amiloride, please talk with your doctor, pharmacist, or other health care provider.
  • Amiloride is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take amiloride or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about amiloride. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to amiloride. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using amiloride.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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