Amiloride Side Effects
Some side effects of amiloride may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to amiloride: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking amiloride: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
numbness or tingly feeling;
muscle pain or weakness;
slow, fast, or uneven heartbeat;
feeling drowsy, restless, or light-headed;
urinating less than usual or not at all;
dry mouth, increased thirst, tiredness, nausea, vomiting;
tremors, confusion; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects of amiloride may include:
mild nausea, loss of appetite;
gas, stomach pain; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to amiloride: compounding powder, oral tablet
Cases of severe hyponatremia have been reported during hydrochlorothiazide-amiloride therapy. In 3 cases, the patients subsequently did well with hydrochlorothiazide and potassium supplementation, suggesting a significant role for amiloride in the development of their hyponatremia.
Significantly elevated serum uric acid, cholesterol, and triglyceride levels have been associated with combination hydrochlorothiazide-amiloride therapy. These metabolic abnormalities may not be due to amiloride since they are reported during hydrochlorothiazide monotherapy.
Amiloride is known to cause significant elevations in serum aldosterone, renin, and angiotensin II levels.
Metabolic side effects are the most common. Amiloride may cause hyperkalemia in up to 10% of patients, although the risk is decreased to about 1% to 2% when thiazide or loop diuretics are coadministered. Patients with diabetes or who are on other potassium-sparing therapy, ACE inhibitors, or potassium supplementation are predisposed to amiloride-induced hyperkalemia.
Renal side effects including renal insufficiency is unusual after amiloride monotherapy because it is only a weak diuretic.
Gastrointestinal complaints of diarrhea, nausea, constipation, anorexia, and general abdominal pain occur less than 5% of patients.
Nervous system side effects occur in less than 3% of patients, and include headache, weakness, and fatigue. Encephalopathy may be induced by amiloride-associated metabolic changes in some patients with severe liver disease.
Cardiovascular side effects are mainly limited to the increased risk of hyperkalemia-induced arrhythmias in patients at risk for arrhythmias. Angina pectoris, arrhythmias, and orthostatic hypotension are reported in less than 1% of patients.
Genitourinary problems include rare complaints of impotence. Polyuria and urinary frequency are reported in less than 1% of patients.
More amiloride resources
- amiloride Concise Consumer Information (Cerner Multum)
- amiloride MedFacts Consumer Leaflet (Wolters Kluwer)
- amiloride Advanced Consumer (Micromedex) - Includes Dosage Information
- Amiloride Prescribing Information (FDA)
- Amiloride Hydrochloride Monograph (AHFS DI)
- Midamor Prescribing Information (FDA)
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